Silver sulfadiazine–immobilized celluloses as biocompatible polymeric biocides

Abstract

Sulfadiazine was immobilized onto cotton cellulose using ethylene glycol diglycidyl ether as a binder. Upon treatment with diluted silver nitrate aqueous solution, the sulfadiazine moieties in the immobilized celluloses were transformed into silver–sulfadiazine coordination complexes. The resulting silver sulfadiazine–immobilized celluloses provided a 6-log reduction of 108 CFU mL−1 of Staphylococcus aureus (Gram-positive bacteria), Escherichia coli (Gram-negative bacteria), methicillin-resistant Staphylococcus aureus (drug-resistant bacteria), vancomycin-resistant Enterococcus faecium (drug-resistant bacteria), and Candida albicans (fungi) in 30–60 minutes, and a 5-log reduction of 107 PFU mL−1 of MS2 virus in 120 minutes. The antibacterial, antifungal, and antiviral activities were both durable and rechargeable. Additionally, trypan blue assay suggested that the new silver sulfadiazine–immobilized celluloses sustained excellent mammal cell viability, pointing to great potentials of the new materials for a broad range of health care–related applications.

Supercritical carbon dioxide application using hydantoin acrylamide for biocidal functionalization of polyester

“…Biocidal functionalization on textiles have also been studied extensively, and many chemicals have been explored and developed for inhibiting the growth of bacteria and preventing infections and diseases in medical applications. Many antimicrobials such as organometallics and metal ions (especially silver ions) [ [4] , [5] , [6] , [7] ], phenols [ [8] , [9] , [10] , [11] , [12] , [13] ], biguanides, quaternary ammonium salts [ [14] , [15] , [16] ], organo-silicones and N -halamines [ [17] , [18] , [19] ] have been used in textile industry for decades. N -halamines can have the forms of amine, amide, and imide as a biocidal agent.…”

Preparation of biocidal 4‐ethyl‐4‐(hydroxymethyl)oxazolidin‐2‐one‐basedN‐halamine polysiloxane for impregnation of polypropylene in supercritical CO2

“…Most commonly used biocidal groups are N ‐halamines, quaternary ammonia salts, and heavy‐metal ions . Wherein, N‐halamine is a biocidal compound with many advantages.…”

Synthesis of polysiloxane with 5,5‐dimethylhydantoin‐based N‐halamine pendants for biocidal functionalization of polyethylene by supercritical impregnation

“…Surface modification of polymers with antibacterial groups such as N ‐halamines, quaternary ammonia salts, and heavy‐metal ions is an efficient means to avoid the growth of microorganisms and provide extended applications in biomaterials and daily life. PE is the most commonly used plastic due to its many attractive properties including flexibility, nontoxicity, high strength, and chemical stability.…”