Silver Sulfadiazine Nanoethogel for Burn Healing: Characterization and Investigation of Its
 In Vivo
 Effects

Razavi, Seyedehhamideh; Partoazar, Alireza; Takzaree, Nasrin; Fasihi-Ramandi, Mahdi; Bahador, Abas; Darvishi, Mohammad Hasan

doi:10.2217/nnm-2017-0385

Cited by 27 publications

(12 citation statements)

References 33 publications

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“…The concentration of DOX in the supernatant was measured by UV spectrophotometry (Varian, Cary 100 UV/Vis Spectrophotometer, USA) at 480 nm. The drug loading and encapsulation efficiency of DOX were calculated by the following formulas: 56 Drug loading contentð%Þ ¼ the weight of DOX in the nanoparticles the gross weight of the nanoparticles � 100…”

Section: Evaluation Of Encapsulation Efficiencymentioning

confidence: 99%

Preparation and Evaluation of Doxorubicin-Loaded PLA–PEG–FA Copolymer Containing Superparamagnetic Iron Oxide Nanoparticles (SPIONs) for Cancer Treatment: Combination Therapy with Hyperthermia and Chemotherapy

Khammarnia¹,

Nourbakhsh²,

Saber³

et al. 2020

IJN

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Background: Among the novel cancer treatment strategies, combination therapy is a cornerstone of cancer therapy. Materials and Methods: Here, combination therapy with targeted polymer, magnetic hyperthermia and chemotherapy was presented as an effective therapeutic technique. The DOX-loaded PLA-PEG-FA magnetic nanoparticles (nanocarrier) were prepared via a double emulsion method. The nanocarriers were characterized by particle size, zeta potential, morphology, saturation magnetizations and heat generation capacity, and the encapsulation efficiency, drug content and in-vitro drug release for various weight ratios of PLA:DOX. Then, cytotoxicity, cellular uptake and apoptosis level of nanocarrier-treated cells for HeLa and CT26 cells were investigated by MTT assay, flow cytometry, and apoptosis detection kit. Results and Conclusions: The synthesized nanoparticles were spherical in shape, had low aggregation and considerable magnetic properties. Meanwhile, the drug content and encapsulation efficiency of nanoparticles can be achieved by varying the weight ratios of PLA:DOX. The saturation magnetizations of nanocarriers in the maximum applied magnetic field were 59/447 emu/g and 28/224 emu/g, respectively. Heat generation capacity of MNPs and nanocarriers were evaluated in the external AC magnetic field by a hyperthermia device. The highest temperature, 44.2°C, was measured in the nanocarriers suspension at w/w ratio 10:1 (polymer:DOX weight ratio) after exposed to the magnetic field for 60 minutes. The encapsulation efficiency improved with increasing polymer concentration, since the highest DOX encapsulation efficiency was related to the nanocarriers' suspension at w/w ratio 50:1 (79.6 ± 6.4%). However, the highest DOX loading efficiency was measured in the nanocarriers' suspension at w/w ratio 10:1 (5.14 ± 0.6%). The uptake efficiency and apoptosis level of nanocarrier-treated cells were higher than those of nanocarriers (folic acid free) and free DOX-treated cells in both cell lines. Therefore, this targeted nanocarrier may offer a promising nanosystem for cancer-combined chemotherapy and hyperthermia.

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Section: Evaluation Of Encapsulation Efficiencymentioning

confidence: 99%

Preparation and Evaluation of Doxorubicin-Loaded PLA–PEG–FA Copolymer Containing Superparamagnetic Iron Oxide Nanoparticles (SPIONs) for Cancer Treatment: Combination Therapy with Hyperthermia and Chemotherapy

Khammarnia¹,

Nourbakhsh²,

Saber³

et al. 2020

IJN

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“…[27][28][29] Although topical silver sulfadiazine has been used in burn clinics as a potent antibacterial agent, it is not an antiinflammatory agent and its long-term use caused toxicity and impaired wound healing in burn patient and experiments as well. 19,30 In this study, the level of TGF-β1 cytokine production was less in ROCEN-treated group compared with zinc oxide group in injured tissue of rats after 7 days of topical application. Song et al showed that zinc oxide could protect the intestinal barrier via mitogen-activated protein kinases and TGF-β1 signaling pathways in weaned pigs.…”

Section: Discussionmentioning

confidence: 51%

“…[16][17][18] Recent studies presented the liposomal formulation as a promising tool in burn and wound therapy with no adverse effects on skin, which causes less drug toxicity as well as improvement of wound healing. 16,19,20 The goal of this study was to assess the effect of the liposome formulation of ASU (as named ROCEN) on burn wound healing in a second-degree burn model in rats. Also, the analgesic activity of ROCEN was evaluated by tail-flick and hotplate tests in which a heat stimulus was used to induce pain.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of ROCEN on Burn Wound Healing and Thermal Pain: Transforming Growth Factor-β1 Activation

Goudarzi¹,

Nasab

Saffari

et al. 2020

The International Journal of Lower Extremity Wounds

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The present study aimed to evaluate the effect of liposomal arthrocen 2% (ROCEN) on the healing of burn wound and pain alleviation of thermal stimuli in a rat model of the second-degree burn. The results showed that ROCEN formulation significantly improved the main parameters of burn wound healing in a short period of time (7 days). The percentage of wound surface was also reduced significantly compared with the control group following once daily application of ROCEN for 14 days. The level of TGF (transforming growth factor)-β1 cytokine was also elevated significantly in the burn tissue treated with ROCEN almost the same as zinc oxide cream. Also, ROCEN showed a significant analgesic effect evaluated by 2 models of acute thermal pain, tail-flick and hotplate tests, which suggested that the formulation may act as a pain reliever in burn injuries. In conclusion, the application of the topical formulation of ROCEN may have benefits in the acceleration of the wound healing process and alleviation of the pain due to burn injuries.

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“…Razavi et al relied on ethosomal penetrating power and formulated (SSD) nanoethosomal gel using carbopol 974 as gelling agent [72]. SSD nanoethosomal gel was tested on rats with a second degree of burn.…”

Section: Ethosomesmentioning

confidence: 99%

Vesicular Systems Used for Wound Healing

Abdelfattah

Nasr

Ali

et al. 2021

Archives of Pharmaceutical Sciences Ain Shams University

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When the skin is injured through physical, chemical, mechanical, and/or thermal damage, a spontaneous series of events start to happen, often called the "cascade of healing," to restore the injured tissues, replace the damaged structures and prevent the invasion of pathogens into the damaged tissues. Many traditional products are available for wound healing such as gels, creams, ointments, dressings, and solutions, which depend mainly on moisture intake to help tissue repair, yet they do not provide optimal conditions to permit recovery of the wounds. Nanocarriers play a significant role in wound healing since they are reported to improve drug delivery into the skin through the alternation of pharmacokinetics and biodistribution of drugs, hence they increase the bioavailability of drugs. Vesicular systems such as liposomes, niosomes, transfersomes, penetration enhancer containing vesicles (PEVs), and ethosomes are among the carriers proven to enhance the therapeutic action of drugs applied for wound healing. In this review, we summarize and discuss different vesicular systems used for wound healing, their composition, their advantages and disadvantages, their methods of preparation, and their mechanisms of skin penetration.

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Silver Sulfadiazine Nanoethogel for Burn Healing: Characterization and Investigation of Its In Vivo Effects

Abstract: The SSD ethogels promotes the therapeutic effect of SSD for burn treatment.

Cited by 27 publications

References 33 publications

<p>Preparation and Evaluation of Doxorubicin-Loaded PLA–PEG–FA Copolymer Containing Superparamagnetic Iron Oxide Nanoparticles (SPIONs) for Cancer Treatment: Combination Therapy with Hyperthermia and Chemotherapy</p>

<p>Preparation and Evaluation of Doxorubicin-Loaded PLA–PEG–FA Copolymer Containing Superparamagnetic Iron Oxide Nanoparticles (SPIONs) for Cancer Treatment: Combination Therapy with Hyperthermia and Chemotherapy</p>

Evaluation of ROCEN on Burn Wound Healing and Thermal Pain: Transforming Growth Factor-β1 Activation

Vesicular Systems Used for Wound Healing

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