Silver–titanium dioxide nanocomposites as effective antimicrobial and antibiofilm agents

Lungu, M.; Gavriliu, Ștefania; Enescu, E.; Ion, Ioana; Brătulescu, Alexandra; Mihăescu, Grigore; Măruţescu, Luminiţa; Chifiriuc, Mariana Carmen

doi:10.1007/s11051-013-2203-3

Cited by 46 publications

(19 citation statements)

References 42 publications

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“…[71][72] Antibacterial activities of chloramphenicol, kanamycin, erythromycin and ampicillin against Gram-positive and Gram negative and activity of cefoperazone against methicillinresistant S. aureus (MRSA) were increased in presence of AgNPs. Lungu et al 74 demonstrated that Ag-TiO 2 NCs exhibited very strong antibiofilm activity. Lungu et al 74 demonstrated that Ag-TiO 2 NCs exhibited very strong antibiofilm activity.…”

Section: Agnps and Nmsmentioning

confidence: 99%

Nanoparticles vs. biofilms: a battle against another paradigm of antibiotic resistance

2016

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Microbes form surface adherent community structures called biofilms and these biofilms play a critical role in infection. Biofilms impart antibiotic resistance and sometimes become recalcitrant to host immune system. It has reported by the National Institutes of Health that more than 80% of the bacterial infections caused by biofilms formation. Such kind of infection is also prevalent in biomedical devices which becomes a source of infection.The treatment of biofilm mediated infections is a big challenge that requires more sensitive and effective antibiofilm strategies for their removal. Nanoparticles targeted antibiofilm therapy has gained tremendous impetus in last decade due to their unique features. These are wonder particles having a wide spectrum biological applications and among these there antibiofilm activity is significantly useful. These particles are reactive entities and can easily infiltrate into the matrix which acts as a barrier for many antibiotics. Biomedical surfaces are also nano-functionalized by coating, impregnation or embedding nanomaterials to prevent biofilm formation. The study of interaction between nanoparticles and biofilm can provide us more insights about the mechanism of biofilm regulation. In this review article several classes of NPs effective against a broad range of microbial biofilms, both in vivo and in vitro are described. The application of nanoparticles against biofilm will help to fight resistant infections and will share its role in improving human health in the future.

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Section: Agnps and Nmsmentioning

confidence: 99%

Nanoparticles vs. biofilms: a battle against another paradigm of antibiotic resistance

2016

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“…Recently, the development and use of several nanomaterials with biofilm interfering and growth inhibiting properties against P. aeruginosa were reported. Lipophilic [205], silver [206,207,208], titanium [209,210], and bismuth [211] based nanoparticles were synthesized and were found to have strong antimicrobial and antibiofilm activities against P. aeruginosa paving a promising way towards the development of nanomaterials for biomedical applications to control P. aeruginosa health associated infections as well as other industrial and agricultural applications. Nanostructured surfaces (such as those created by anodizing titanium) have been reported over the past 5 years to decrease bacterial attachment and growth due to their unique surface energetics that promote the absorption of natural antibacterial proteins from bodily fluids given that nanoscale features can provide a 'bed-ofnails' to keep relatively stiff bacterial membranes from attaching.…”

Section: Nanoantimicrobials and Nanoantibioticsmentioning

confidence: 99%

Pseudomonas Aeruginosa : Arsenal of Resistance Mechanisms, Decades of Changing Resistance Profiles, and Future Antimicrobial Therapies

et al. 2015

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Antimicrobial resistance is one of the most serious public health issues facing humans since the discovery of antimicrobial agents. The frequent, prolonged, and uncontrolled use of antimicrobial agents are major factors in the emergence of antimicrobial-resistant bacterial strains, including multidrug-resistant variants. Pseudomonas aeruginosa is a leading cause of nosocomial infections. The abundant data on the increased resistance to antipseudomonal agents support the need for global action. There is a paucity of new classes of antibiotics active against P. aeruginosa. Here, we discuss recent antibacterial resistance profiles and mechanisms of resistance by P. aeruginosa. We also review future potential methods for controlling antibiotic-resistant bacteria, such as phage therapy, nanotechnology and antipseudomonal vaccines.

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“…Lungu et al . () have prepared nearly spherical nanocomposite particles 15 and 30 nm in size, consisting of TiO 2 nanoparticles with different concentrations of deposited silver nanoparticles. A higher proportion of silver provides the material with increased antimicrobial activity.…”

Section: Biologically Nonsystemic Eradication Of Pseudomonas Biofilmmentioning

confidence: 99%

Pseudomonasbiofilms: possibilities of their control

Masák

Čejková

Schreiberová

et al. 2014

FEMS Microbiol Ecol

124

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Genus Pseudomonas includes a large number of species that can be encountered in biotechnological processes as well as in the role of serious human or plant pathogens. Pseudomonads easily form biofilms on various types of surfaces. The biofilm phenotype is characterized by an increased resistance to environmental influences including resistance to antibiotics and other disinfectants, causing a number of problems in health care, food industry, and other areas. Considerable attention is therefore paid to the possibilities of eradication/destruction of pseudomonads biofilms both in terms of understanding the mechanisms of biofilm formation and at the level of finding suitable antibiofilm tools applicable in practice. The first part of this review is devoted to an overview of the regulatory mechanisms that are directly or indirectly involved in the formation of biofilm. The most effective approaches to suppressing the formation of biofilm that do not cause the development of resistance are based on the application of substances that interfere with the regulatory molecules or block the appropriate regulatory mechanisms involved in biofilm development by the cells. Pseudomonads biofilm formation is, similar to other microorganisms, a sophisticated process with many regulatory elements. The suppression of this process therefore also requires multiple antibiofilm tools.

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Silver–titanium dioxide nanocomposites as effective antimicrobial and antibiofilm agents

Cited by 46 publications

References 42 publications

Nanoparticles vs. biofilms: a battle against another paradigm of antibiotic resistance

Nanoparticles vs. biofilms: a battle against another paradigm of antibiotic resistance

Pseudomonas Aeruginosa : Arsenal of Resistance Mechanisms, Decades of Changing Resistance Profiles, and Future Antimicrobial Therapies

Pseudomonasbiofilms: possibilities of their control

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