Silver toxicity masquerading as hypocaeruloplasminaemia

Tran, Huy; Song, Shuzhen

doi:10.1080/00313020701329781

Cited by 8 publications

(3 citation statements)

References 7 publications

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“…As copper metabolism was altered by silver administration, the serum copper concentration was decreased to 60% of the control value. 8,9 The first case's result was different to previous reports, and in that the serum copper level was 99.1 lg/dl (normal range 70.0-155 lg/dl).…”

Section: Discussioncontrasting

confidence: 64%

Three systemic argyria cases after ingestion of colloidal silver solution

et al. 2010

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Section: Discussioncontrasting

confidence: 64%

Three systemic argyria cases after ingestion of colloidal silver solution

et al. 2010

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“…This effect may be explained because silver alters copper metabolism. In experimental animal models and in humans [ 16 , 17 ], it has been reported that serum copper concentrations decrease as a result of altered copper metabolism after silver administration. The reduction in cellular copper status observed in our case may therefore be due to silver toxicity.…”

Section: Discussionmentioning

confidence: 99%

A case of generalized argyria presenting with muscle weakness

Jung

Joo

Suh

et al. 2017

Ann of Occup and Environ Med

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BackgroundArgyria is a rare irreversible cutaneous pigmentation disorder caused by prolonged exposure to silver. Herein, we report a case of generalized argyria that developed after chronic ingestion of soluble silver-nano particles and presented with muscle weakness.Case presentationA 74-year-old woman visited our emergency room, complaining of fever and mental deterioration. She was diagnosed with acute pyelonephritis and recovered after antibiotic therapy. At presentation, diffuse slate gray-bluish pigmented patches were noticed on her face and nails. Two months prior to visiting our hospital, she was diagnosed with inflammatory myopathy and given steroid therapy at another hospital. We performed a nerve conduction study that revealed polyneuropathy. In skin biopsies from pigmented areas of the forehead and nose, the histopathologic results showed brown-black granules in basement membranes of sweat gland epithelia, which are diagnostic findings of argyria. We reviewed pathology slides obtained from the left thigh muscles and found markedly degenerated myofibers with disorganization of myofibrils without inflammatory reactions, consistent with unspecified myopathy, rather than inflammatory myopathy. The patient was diagnosed with generalized argyria with polyneuropathy and myopathy and transferred to a rehabilitation institution after being tapered off of steroids.ConclusionsClinicians should be aware of clinical manifestations of argyria and consider it in differential diagnosis when they examine patients who present with skin pigmentation and muscle weakness.

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“…Silver has been observed to alter copper metabolism. As the result of altered copper metabolism by silver administration, serum copper concentration and ceruloplasmin (CP) oxidase activity were decreased in experimental animals and humans [Johansson et al, 1982;Sugawara and Sugawara, 1984;Hirasawa et al, 1994;Tran and Song, 2007]. Interaction of silver with copper should be considered in ruling out Wilson's disease.…”

Section: Discussionmentioning

confidence: 99%

A case of generalized argyria after ingestion of colloidal silver solution

Kim

Suh

Jeong

et al. 2008

American J Industrial Med

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A 58-year-old woman was referred to our hospital due to progressive skin darkening, which began 5 months previously. The patient had strikingly diffuse blue-gray discoloration of the skin, most prominent in sun-exposed areas, especially her face and hands. The oral mucosa, tongue, gums, eye conjunctiva, ears, nail beds, and trunk were also involved. Bluish-gray discoloration of all nails was aggravated by cold weather. She had ingested 1 L of colloidal silver solution daily for approximately 16 months as a traditional remedy. Her serum silver concentration was 381 ng/ml which was a very high (reference level: <15 ng/ml). Light microscopic examination of a punch biopsy specimen from her nose revealed fine, minute, round, and brown-black granules deposited in the basement membrane of hair follicular epithelium. Scanning electron microscopic examination showed electron-dense granules deposited in the intercellular space of sweat glands. Energy disperse X-ray spectrometry analysis demonstrated peaks for silver and sulfur in the dense black deposits. The ingestion of colloidal silver appears to be an increasing practice among patients using alternative health practices. All silver-containing products including colloidal silver should be labeled with a clear warning to prevent argyria, especially in alternative health practices.

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Silver toxicity masquerading as hypocaeruloplasminaemia

Cited by 8 publications

References 7 publications

Three systemic argyria cases after ingestion of colloidal silver solution

Three systemic argyria cases after ingestion of colloidal silver solution

A case of generalized argyria presenting with muscle weakness

A case of generalized argyria after ingestion of colloidal silver solution

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