SilverSol® a Nano-Silver Preparation: A Multidimensional Approach to Advanced Wound Healing

Souza, Anselm de; Vora, A. H.; Mehta, Ankur; Moeller, K W; Moeller, Cameron; Willoughby, A. J. M.; Godse, C. S.

doi:10.1007/978-981-16-2677-7_12

Cited by 9 publications

(7 citation statements)

References 43 publications

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“…sheep [21], and human system [22] respectively. Silversol ® has been shown to be safe for human consumption [7], and silver in general up to 5 µg/Kg body weight per day is believed to be safe for humans (https://www.govinfo.gov/content/pkg/FR-1999-08-17/html/99-21253.htm). While considerable insight has been developed regarding the anti-nematode mode of action of albendazoles and avermectins [23], that is not the case with silver though its anthelmintic action has been known [24].…”

Section: Resultsmentioning

confidence: 99%

“…It is a colloidal silver preparation reported to possess multiple biological activities. This formulation has been reported to possess microbicidal activity [5], and found application in the areas of wound healing [6], burn treatment [7], and oral care [8]. Different Silversol ® products have received various regulatory approvals from competent authorities in the US, India and Canada, whose details can be accessed in [7].…”

Section: Introductionmentioning

confidence: 99%

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Potent anthelmintic activity of a colloidal nano-silver formulation (Silversol®) against the model worm Caenorhabditis elegans

Gajera

Godse

DeSouza

et al. 2023

Preprint

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Objective In the background of a very small number of effective anthelmintics available today with a narrow activity spectrum, and a rise in resistance against them among parasitic helminths, there is an urgent need for discovery of novel broad-spectrum anthelmintics displaying no or minimal toxicity towards the host. Silver being used since centuries for therapeutic purposes and considered safe for human consumption, we investigated anthelmintic activity of a colloidal nanosilver formulation Silversol®. Anthelmintic efficacy of the test formulation was assayed employing the nematode Caenorhabditis elegans as a model worm through a live-dead count. Results Silversol® exerted anthelmintic action superior to one of the positive controls (Benzimidazole), and almost at par to another positive control (Ivermectin). At concentrations ≥2 ppm, it could kill all the worms present in the experimental well. Lower concentrations of silver were found to have a cuticle-damaging action on worms. Further investigation is warranted to assess whether Silversol® can exert similar potent activity against different species of parasitic helminths, and elucidate the underlying molecular mechanisms of action.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Potent anthelmintic activity of a colloidal nano-silver formulation (Silversol®) against the model worm Caenorhabditis elegans

Gajera

Godse

DeSouza

et al. 2023

Preprint

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“…Ltd., Mumbai, India. This colloidal silver mixture is documented to possess multiple biological effects (de Souza et al, 2021). It comprises of zero-valent metallic silver particles in their elemental form that are covered in silver oxide.…”

Section: Methodsmentioning

confidence: 99%

“…Since metallic form of silver is believed to be more potent than its ionic form (de Souza et al, 2021), we chose a solution of colloidal silver for the purpose of this study. Target pathogen for this study was an antibiotic-resistant strain of Staphylococcus aureus .…”

Section: Introductionmentioning

confidence: 99%

Silversol^®(a colloidal nanosilver formulation) inhibits growth of antibiotic-resistantStaphylococcus aureusby disrupting its physiology in multiple ways

Thakkar,

Gajera,

Godse

et al. 2024

Preprint

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Antibacterial effect of a colloidal nanosilver formulation Silversol was investigated against an antibioticresistant strain of Staphylococcus aureus. Lower concentrations of the test formulation exerted bacteriostatic and, its higher concentrations exerted bactericidal effect against this pathogen. Silversol at sub-lethal concentration was found to disturb multiple physiological traits of S. aureus such as growth, antibiotic susceptibility, membrane permeability, efflux, protein synthesis and export, biofilm and exopolysaccharide production, etc. Transcriptome data revealed the genes coding for transcriptional regulators, efflux machinery, transferases, beta-lactam resistance, oxidoreductases, metal homeostasis, virulence factors, and arginine biosynthesis to get expressed differently under influence of the test formulation. Genes (argG and argH) involved in arginine biosynthesis emerged among the major targets of Silversol in S. aureus.

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“…We chose a colloidal nanosilver solution as a test formulation for this study, as the metallic form of silver is believed to be more potent than its ionic counterpart [ 23 ]. Nanoparticles are defined as particles of size < 100 nm [ 24 ], and nanoparticles of metals can be expected to score high on the parameter of bioavailability compared to larger particles of the same metal [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Silversol® (a Colloidal Nanosilver Formulation) Inhibits Growth of Antibiotic-Resistant Staphylococcus aureus by Disrupting Its Physiology in Multiple Ways

Thakkar,

Gajera,

Mehta

et al. 2024

Pharmaceutics

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Antibiotic-resistant strains of Staphylococcus aureus are being viewed as a serious threat by various public health agencies. Identifying novel targets in this important pathogen is crucial to the development of new effective antibacterial formulations. We investigated the antibacterial effect of a colloidal nanosilver formulation, Silversol®, against an antibiotic-resistant strain of S. aureus using appropriate in vitro assays. Moreover, we deciphered the molecular mechanisms underlying this formulation’s anti-S. aureus activity using whole transcriptome analysis. Lower concentrations of the test formulation exerted a bacteriostatic effect against this pathogen, and higher concentrations exerted a bactericidal effect. Silversol® at sub-lethal concentration was found to disturb multiple physiological traits of S. aureus such as growth, antibiotic susceptibility, membrane permeability, efflux, protein synthesis and export, biofilm and exopolysaccharide production, etc. Transcriptome data revealed that the genes coding for transcriptional regulators, efflux machinery, transferases, β-lactam resistance, oxidoreductases, metal homeostasis, virulence factors, and arginine biosynthesis are expressed differently under the influence of the test formulation. Genes (argG and argH) involved in arginine biosynthesis emerged among the major targets of Silversol®’s antibacterial activity against S. aureus.

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SilverSol® a Nano-Silver Preparation: A Multidimensional Approach to Advanced Wound Healing

Cited by 9 publications

References 43 publications

Potent anthelmintic activity of a colloidal nano-silver formulation (Silversol®) against the model worm Caenorhabditis elegans

Potent anthelmintic activity of a colloidal nano-silver formulation (Silversol®) against the model worm Caenorhabditis elegans

Silversol^®(a colloidal nanosilver formulation) inhibits growth of antibiotic-resistantStaphylococcus aureusby disrupting its physiology in multiple ways

Silversol® (a Colloidal Nanosilver Formulation) Inhibits Growth of Antibiotic-Resistant Staphylococcus aureus by Disrupting Its Physiology in Multiple Ways

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SilverSol® a Nano-Silver Preparation: A Multidimensional Approach to Advanced Wound Healing

Cited by 9 publications

References 43 publications

Potent anthelmintic activity of a colloidal nano-silver formulation (Silversol®) against the model worm Caenorhabditis elegans

Potent anthelmintic activity of a colloidal nano-silver formulation (Silversol®) against the model worm Caenorhabditis elegans

Silversol®(a colloidal nanosilver formulation) inhibits growth of antibiotic-resistantStaphylococcus aureusby disrupting its physiology in multiple ways

Silversol® (a Colloidal Nanosilver Formulation) Inhibits Growth of Antibiotic-Resistant Staphylococcus aureus by Disrupting Its Physiology in Multiple Ways

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Silversol^®(a colloidal nanosilver formulation) inhibits growth of antibiotic-resistantStaphylococcus aureusby disrupting its physiology in multiple ways