Silymarin administration during pregnancy and breastfeeding: evaluation of initial development and adult behavior of mice

Barbosa, C.C.; Nishimura, Akemy Nogueira; Santos, Mateus Pereira dos; Junior, Walter Dias; Andersen, Mônica Levy; Mazaro-Costa, Renata

doi:10.1016/j.neuro.2020.02.008

Cited by 8 publications

(6 citation statements)

References 21 publications

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“…Animal studies showed controversy regarding the teratogenicity of oral silymarin in mouse and rat models. 28,29 As human studies are lacking, oral and topical silymarin are currently not supposed to be used during pregnancy. Multiple research works considered silymarin as one of the natural galactagogues that increase milk production in humans.…”

Section: Discussionmentioning

confidence: 99%

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Topical Silymarin Cream as a Novel Therapy Versus Salicylic Acid Peels in Acne Vulgaris: A Split-Face Clinical Trial

Atallah,

Badran,

Makhlouf

et al. 2023

J Cutan Med Surg

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Background Acne vulgaris is a common dermatological condition that greatly impacts patients’ self-confidence. Ongoing research is conducted to explore new treatment modalities. Silymarin owns special characteristics that qualify it as a possible treatment for acne vulgaris. Objective We evaluated the efficacy and safety of silymarin cream as a new therapeutic option against salicylic acid peels in the treatment of mild to moderate acne vulgaris. Methods A split-face, comparative, Quasi-experimental clinical trial included 30 patients with acne vulgaris. Salicylic acid 30% peels were applied as an office procedure to one half of the face every 2 weeks for 3 months. Topical silymarin 1.4% cream was prescribed as a home treatment, twice daily, to the other half of the face for 3 months. The results were evaluated using the Global Acne Grading System (GAGS), photographic evaluation, and patient self-assessment scale. The adverse effects during treatment were recorded. The sample size was calculated by Stata/IC 16.1. Results After treatment, a significant reduction of GAGS was noted on both sides of the face, with an insignificant difference between both treatments. The comparative photographic evaluation and patient self-assessment scale were also insignificant. Hyperpigmentation was recorded in 2 cases on the salicylic acid-treated side. No side effects for silymarin cream were observed. Conclusion Topical silymarin cream 1.4% showed comparable results to Salicylic acid 30% peels. It can be considered a promising safe treatment modality for mild to moderate acne vulgaris.

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Section: Discussionmentioning

confidence: 99%

“…32 Also, a recent animal study on mice documented the absence of adverse effects of silymarin on the offspring during breastfeeding. 29…”

Section: Discussionmentioning

confidence: 99%

Topical Silymarin Cream as a Novel Therapy Versus Salicylic Acid Peels in Acne Vulgaris: A Split-Face Clinical Trial

Atallah,

Badran,

Makhlouf

et al. 2023

J Cutan Med Surg

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“…Although animal studies showed teratogenic effects aer intraperitoneal administration, 109 oral feeding to mice during pregnancy and lactation (up to 300 mg kg À1 for 39 days) showed no teratogenic or malformative effect. 110 An important toxicological consideration is potential interactions with other food supplements or prescription drugs taken concomitantly. 53 Most in vitro studies have focused on the interactions of silymarin or its constituents with cytochromes P450 (CYPs), UDP-glucuronosyl-transferases (UGTs), and/or transporters.…”

Section: Multidrug Resistance Modulation Activitymentioning

confidence: 99%

“…Although animal studies showed teratogenic effects after intraperitoneal administration, 109 oral feeding to mice during pregnancy and lactation (up to 300 mg kg −1 for 39 days) showed no teratogenic or malformative effect. 110…”

Section: Toxicity Adverse Effects and Interactions With Other Drugsmentioning

confidence: 99%

Silybin and its congeners: from traditional medicine to molecular effects

Křen

Valentová

2022

Nat. Prod. Rep.

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“…The efficacy of the plants in stimulating/promoting milk production was proven via animal testing. However, many plants have yet to be tested and analysed in human clinical trials [46][47][48][49][50][51][52][53][54]. An animal model research is commonly conducted to verify the efficacy of a particular material before proceeding to the clinical study, which involves human experimental group.…”

Section: Excluded Studiesmentioning

confidence: 99%

Clinical Study on Plant Galactagogue Worldwide in Promoting Women’s Lactation: a Scoping Review

Kwan

Abdul‐Rahman

2021

Plant Foods Hum Nutr

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Human milk is recommended by the World Health Organization (WHO) for the general well-being of infants. However, many mothers face an insufficient milk supply to breastfeed their children. Galactagogue, in particular, plant galactagogue, serves as a method to promote lactation. This in-depth review examines the evidence supporting different plants' galactagogic activity through clinical studies around the globe. A scoping review approach was adopted to establish the research questions, and define the findings, selection and analysis of the study. This scoping review highlights and compiles the clinical research performed globally involving plant galactagogue to better inform the medical practitioners, lactation consultants, nursing mothers, communities and relevant personnel on practicing, guidelines, policymaking and research. In general, a total of 1041 research publications were retrieved from different global bibliographic databases, of which only 13 articles were retained for analysis after applying the exclusion criteria. A total of 14 types of plants have undergone clinical studies in the past decade to verify their galactagogic activity. All but two showed a positive effect on promoting milk production. There were 42 articles categorised as excluded studies. The category includes review articles, surveys, case reports, introductory articles of regional plant galactagogue and preclinical studies, which involves animal testing and the studies exploring other issues related to plant galactagogue. The findings demonstrate that there is a significant research gap on the plant galactagogue using clinical studies. More clinical research is necessary to identify and verify the efficacy of various types of plant galactagogue for the benefit of humankind.

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Silymarin administration during pregnancy and breastfeeding: evaluation of initial development and adult behavior of mice

Cited by 8 publications

References 21 publications

Topical Silymarin Cream as a Novel Therapy Versus Salicylic Acid Peels in Acne Vulgaris: A Split-Face Clinical Trial

Topical Silymarin Cream as a Novel Therapy Versus Salicylic Acid Peels in Acne Vulgaris: A Split-Face Clinical Trial

Silybin and its congeners: from traditional medicine to molecular effects

Clinical Study on Plant Galactagogue Worldwide in Promoting Women’s Lactation: a Scoping Review

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