Silymarin alleviates hepatic oxidative stress and protects against metabolic disorders in high-fat diet-fed mice

Feng, Bin; Wang, Mengqi; Huang, Bin; Shen, Shanmei; Bi, Yan; Zhu, Dalong

doi:10.3109/10715762.2015.1116689

Cited by 47 publications

(42 citation statements)

References 43 publications

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“…There are many possible mechanisms by which silymarin can improve the antioxidant defense mechanisms and oxidative status. Recent studies revealed that silymarin can scavenge free radicals in the gut, prevent the formation of free radicals by inhibiting specific ROS-producing enzymes and improve the integrity of electron-transport chain of mitochondria in stress conditions (Gabrielova et al, 2015;Surai, 2015;Feng et al, 2016). Silymarin was also shown to maintain an optimal redox balance in cells by activating a range of antioxidant enzymes and non-enzymatic antioxidants via the activation of specific transcription factors (Zhao et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, due to their localization, mitochondrial enzymes are particularly vulnerable to ROS, leading to mitochondrial dysfunction and increases in oxidative pressure during critical reproductive periods in sows (Lapointe, 2014). There are many possible mechanisms by which silymarin can improve the antioxidant defense mechanisms and oxidative status (Gabrielova et al, 2015;Surai, 2015;Feng et al, 2016), and its beneficial effect in protecting against systemic oxidative stress was recently demonstrated in late-pregnant sows . It is likely that the dose of silymarin needed to elicit antioxidant effects is lower than that required to stimulate milk yield.…”

Section: Introductionmentioning

confidence: 99%

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Providing the plant extract silymarin to lactating sows: effects on litter performance and oxidative stress in sows

Farmer

Lapointe

Cormier

2017

Animal

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Silymarin is an extract from the plant milk thistle that was shown to have antioxidant and hyperprolactinemic properties. Taking into account the essential role of prolactin for lactating sows and the systemic oxidative stress occurring during lactation, it is of interest to investigate the potential beneficial effects of silymarin on lactating sows. A study was therefore carried out to determine the effects of providing either 1 or 8 g/day of the plant extract silymarin to lactating sows. Sows in first, second or third parity were fed conventional diets during gestation and, at farrowing, were assigned as controls (CTL, n = 33), or were fed 1 g/day (SYL1, n = 33) or 8 g/day (SYL8, n = 33) of silymarin. The silymarin was provided in two equal amounts per day, and was fed throughout a 20-day lactation. The performance of sows and their litters was assessed and circulating concentrations of prolactin (days 7 and 18), urea (days 7 and 18) and oxidative status, via protein carbonyls and superoxide dismutase activity (day 18), were measured in sows. Milk samples were obtained on day 18 to measure standard composition. There was no effect of silymarin ( P > 0.10) on circulating prolactin or urea, or on oxidative damage to proteins or antioxidant potential in sows. Lactation feed intake, backfat and BW of sows were unaffected by treatment ( P > 0.10) as was the case for milk composition and piglet growth ( P > 0.10). Results demonstrate that providing up to 8 g/day of the plant extract silymarin to lactating sows had no beneficial effects in terms of circulating prolactin concentrations or oxidative status of sows, or in terms of performances of sows and their litters.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Providing the plant extract silymarin to lactating sows: effects on litter performance and oxidative stress in sows

Farmer

Lapointe

Cormier

2017

Animal

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“…Obesity‐induced insulin resistance seems to be related to chronic inflammation, glucotoxicity, lipotoxicity, and adipokine dysregulation (Cheng et al, ). Moreover, oxidative stress is related to chronic inflammation and insulin resistance (Feng et al, ) and involved in pathogenesis of diabetic complications by damaging pancreatic β‐cell or leading to metabolic disorders (Huseini et al, ). Insulin resistance is the major cause of development of diabetes, hypertension, and cardiovascular complications.…”

Section: Effect On Diabetesmentioning

confidence: 99%

Silybum marianum (milk thistle) and its main constituent, silymarin, as a potential therapeutic plant in metabolic syndrome: A review

Tajmohammadi

Razavi

Hosseinzadeh

2018

Phytotherapy Research

101

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Metabolic syndrome describes a complex metabolic risk factors including obesity, hypertension, dyslipidemia, and diabetes. This syndrome is diagnosed by medical conditions such as weight gain, high blood pressure, high blood glucose, and disturbance in lipid profile. Metabolic syndrome has become as an important and increasing global health problem, so finding potentially novel solutions with less adverse effects is favorable for health problems. Herbal therapy plays an important role for treatment of different diseases. Silybum marianum is a plant that is used for centuries as a herbal treatment in liver and biliary tract diseases. Silymarin is the main component of S. marianum and derived from fruits and seeds of S. marianum (milk thistle). S. marianum has been found to exhibit antioxidant, lipid-lowering, antihypertensive, antidiabetic, antiatherosclerotic, anti-obesity, and hepatoprotective effects. Therefore, the aim of this review is to summarize different animal and human studies regarding the effect of S. marianum in metabolic syndrome and to identify the underlying mechanisms of action.

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“…Observed in metabolic syndrome, insulin resistance is related to DM type 2 and obesity, and is considered as the main cause of DM, HTN, and cardiovascular disorders . There have been flourishing studies into the efficacy of oral silymarin on insulin resistance and glucose intolerance in animal models of obesity induced by a high fat diet . When doses of 30 and 60 mg kg −1 of body weight of silymarin were applied in mice, which had been put on a high fat diet, it significantly improved insulin resistance and obesity.…”

Section: Human Studiesmentioning

confidence: 99%

Effects of silymarin on metabolic syndrome: a review

2018

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Metabolic syndrome is one of the rising global health problems and medical challenges due to several clinical complications it may cause, for example increasing the risk of myocardial infarction and hypertension. However, great attention has been directed toward determining the worthiness of herbal medicines. There are emerging studies on preventive and therapeutic effects of silymarin on different components of metabolic syndrome. Extracted from the dried seeds of milk thistle plant (Silybum marianum L.), silymarin has been used in the treatment of different diseases for many years. Several protective effects have been identified for this herb such as decreasing insulin resistance, regulating blood pressure and lipid profile, as well as antioxidant and cytoprotective effects. This review aims to discuss available human and experimental researches into the promising effects of silymarin on different elements of metabolic syndrome. All related human and experimental papers published from 2012 to date were included in this review. Reviewing different human and experimental studies into the effects of silymarin on metabolic syndrome, we deduced that silymarin possesses promising effects on different components of this syndrome. Although the complete mechanism of action and target organs for silymarin require further verification and investigation, high-risk individuals may benefit from supplementation with this herbal medicine. © 2018 Society of Chemical Industry.

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Silymarin alleviates hepatic oxidative stress and protects against metabolic disorders in high-fat diet-fed mice

Cited by 47 publications

References 43 publications

Providing the plant extract silymarin to lactating sows: effects on litter performance and oxidative stress in sows

Providing the plant extract silymarin to lactating sows: effects on litter performance and oxidative stress in sows

Silybum marianum (milk thistle) and its main constituent, silymarin, as a potential therapeutic plant in metabolic syndrome: A review

Effects of silymarin on metabolic syndrome: a review

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