Silymarin Based Complexes – a mini review

Abstract

Silymarin (SIL) is a component extracted from Silybum marianum herb and is studied in medicine due to its protective activities on certain organs (liver, kidney, heart, brain). The review discusses some methods that increase silymarin bioavailability such as development of complexes with cyclodextrins, phospholipids, liposome and nanostructured material (hydroxyapatite-HAP). The interactions between SIL and alpha-lipoic acid, metallic nanoparticles (gold nanoparticles-GNP, and silver nanoparticles – SNP), some carotenoids (β-carotene and lycopene) and curcumin were debated too. Some combined treatments (e.g. SIL + curcumin) highlighted anticancer activity against colon cancer cells (DLD-1, HCT116 and LoVo) and protective effect against chemicals toxicity.

Interaction of Bioactive Compounds With Ceramic Materials – A Review

“…Silymarin (SIL) is the main component in the plant Silybum marianum, also used since ancient times in the treatment of liver diseases (cirrhosis, jaundice, hepatitis) and biliary diseases [10][11][12]. It is a compound rapidly metabolized, absorbed and eliminated within six hours.…”

Perspectives of Oral Dental Care

“…Curcumin is a vegetable compound widely exploited for its biological activities. Since its bioavailability, bioactivity, stability and physico-chemical behavior are less effective, strategies have been developed to improve curcumin properties by complexing with whey proteins [65][66][67][68], betacyclodextrin [69][70][71][72][73][74] with natural compounds such as piperine , silymarin, resveratrol [75,76], lipids and hydroxyapatite. Due to their unique properties, nanoparticles have found various uses in many fields starting from hydrogen production [77][78][79][80][81][82], synteses of materials with photoluminescence proprieties [83], adsorption capabilities [84,85], photocatalytic proprieties [86] to bio materials [34][35][36][37][38].…”