Silymarin protects against radiocontrast-induced nephropathy in mice

Santos, Verônica de Souza; Peters, Beatriz; Côco, Larissa Zambom; Alves, Gisele Maziero; Assis, Arícia Leone Evangelista Monteiro de; Nogueira, Breno Valentim; Meyrelles, Silvana S.; Porto, Marcella L.; Vasquez, Elisardo C.; Campagnaro, Bianca Prandi; Pereira, Thiago de Melo Costa

doi:10.1016/j.lfs.2019.04.061

Cited by 18 publications

(12 citation statements)

References 60 publications

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“…Since pre-existing CKD is the most common cause of CIN [27,28] , the interplay among the underlying mechanisms of CVD and kidney failure are important. Additionally, inflammation and ROS have been identified as risk factors of CIN and as potential targets for prophylaxis or treatment [29][30][31][32][33][34] . Hence, the elucidation of CIN/CVD interplay in this setting would improve understanding of the signaling processes and progression of the diseases, leading the way to different approaches to either early detection or to identification of novel drug targets.…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress and inflammation in the development of cardiovascular disease and contrast induced nephropathy

Cervantes-Gracia

Raja²,

Llanas-Cornejo

et al. 2020

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Utilization of contrast media to visualize vasculature structures in the setting of cardiovascular disorders (CVD) can lead to acute kidney injury, referred to as contrast-induced nephropathy (CIN). CIN can potentiate mortality and hospitalization in aged individuals, patients with CVD, nephropathy, enhancing kidney damage, and cardiac events. Preventing CIN by identifying risk factors is important. The underlying mechanisms of CIN pathology are unclear, but the key factors include direct cytotoxicity, oxidative stress, vascular and endothelial dysfunction and inflammatory processes. Reactive Oxygen Species and inflammatory mediators have been proposed as key factors influencing the development of CIN and CVD, and the elucidation of the interplay between the mechanisms evoked by them may provide a better understanding of the signaling processes happening in these conditions, thereby potentially enabling early identification, prevention and characterization of novel drug targets.

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Section: Introductionmentioning

confidence: 99%

Oxidative stress and inflammation in the development of cardiovascular disease and contrast induced nephropathy

Cervantes-Gracia

Raja²,

Llanas-Cornejo

et al. 2020

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“…The role of phytotherapy as anti-inflammatory agents is being investigated, and newer hypotheses are focusing upon the balancing of proinflammatory and counterinflammatory mechanisms as important directions for novel remedies. 7…”

Section: Introductionmentioning

confidence: 99%

“…Milk thistle (Mth) is a detoxifying agent and has cell-regulating effects, the directive of cell membrane permeability, suppressive of the 5-lipoxygenase pathway, and uptake of reactive oxygen species (ROS). 7…”

Section: Introductionmentioning

confidence: 99%

“…6 The role of phytotherapy as anti-inflammatory agents is being investigated, and newer hypotheses are focusing upon the balancing of proinflammatory and counterinflammatory mechanisms as important directions for novel remedies. 7 Milk thistle (Mth) is a detoxifying agent and has cellregulating effects, the directive of cell membrane permeability, suppressive of the 5-lipoxygenase pathway, and uptake of reactive oxygen species (ROS). 7 Taraxacum officinale (Tof) has been used to treat hepatitis and digestive diseases, and it has also shown to have anti-inflammatory, antioxidant, and anticarcinogenic effects.…”

Section: Introductionmentioning

confidence: 99%

“…7 Milk thistle (Mth) is a detoxifying agent and has cellregulating effects, the directive of cell membrane permeability, suppressive of the 5-lipoxygenase pathway, and uptake of reactive oxygen species (ROS). 7 Taraxacum officinale (Tof) has been used to treat hepatitis and digestive diseases, and it has also shown to have anti-inflammatory, antioxidant, and anticarcinogenic effects. 8 Catechin is derived from the leaves of Camellia sinensis (Csin) and contains alkaloids and polyphenols.…”

Section: Introductionmentioning

confidence: 99%

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Cross Talk Between TGF-β and JAK Expressions and Nepherotoxicity Induced by Tetrachloromethane: Role of Phytotherapy

et al. 2019

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The aim of the current study is to assess the effectiveness of milk thistle seeds (Mth) in combination with Taraxacum officinale ( Tof) and/or Camellia sinensis ( Csin) against tetrachloromethane (Tcm) renotoxicity in rats. Tetrachloromethane was injected in a single dose, followed by 1-month treatments with Mth, Tof, and Csin alone or in combination. Serum urea, uric acid, and creatinine levels were significantly increased matched with the control group. Masson trichrome stain revealed increase in the deposition of fibrous tissue in the interstitium between the tubules and the renal corpuscles. Immunohistochemical analysis of kidney tissues revealed that Tcm induced an increase in the immune response of tumor growth factor β (TGF-β) and Janus kinase (JAK) protein expressions and cysteine–aspartic acid protease 3 (caspase 3), while B-cell lymphoma 2 (Bcl2) was downregulated. Treatment with the antioxidants in question either alone or in combination ameliorated all kidney function parameters and showed mild immune reactivity toward TGF-β and JAK protein expressions in blood vessels and glomeruli in the kidney tissues and downregulated caspase 3 and activated Bcl2 protein expression. The combination regimen of the 3 antioxidants showed the most significant renoprotective effect. This was also confirmed histopathologically. It was concluded that the antioxidant mixture is considered as a promising candidate toward renal dysfunction and immune reactivity induced by Tcm and other toxicants.

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Preventing contrast‐induced nephropathy (CIN) with herbal medicines: A review

Boozari

Hosseinzadeh

2020

Phytotherapy Research

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Objectives: Currently, the use of iodinated contrast media in diagnostic imaging has been increased in clinical medicine. Contrast-induced nephropathy (CIN) is an important adverse effect of contrast media injection. According to the significant role of oxidative stress in the pathophysiology of CIN, different herbal antioxidants have been used for the prevention of nephropathy in different studies. In this review, we discussed the preventive effects of herbal medicine and natural products against CIN. Methods: We searched the electronic databases or search engines including PubMed, Scopus, ISI, Google Scholar with search terms such as "Contrast-induced nephropathy" and "Herbal medicine," "Contrast acute kidney injury" AND "natural products" and similar headings such as plant and extract. Results: Known medicinal plants and active ingredients such as green tea, ginger, garlic, silymarin, curcumin, resveratrol, and thymoquinone have been examined for prophylactic effects or treatment of contrast media nephropathy. Conclusion: Herbal medicines have promising effects in the laboratory-based studies for the prevention and/or treatment of CIN. However, more practical and completed clinical trials are needed to investigate the clinical benefits of natural products against CIN.

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Silymarin protects against radiocontrast-induced nephropathy in mice

Cited by 18 publications

References 60 publications

Oxidative stress and inflammation in the development of cardiovascular disease and contrast induced nephropathy

Oxidative stress and inflammation in the development of cardiovascular disease and contrast induced nephropathy

Cross Talk Between TGF-β and JAK Expressions and Nepherotoxicity Induced by Tetrachloromethane: Role of Phytotherapy

Preventing contrast‐induced nephropathy (CIN) with herbal medicines: A review

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