2012
DOI: 10.1128/jvi.06813-11
|View full text |Cite
|
Sign up to set email alerts
|

Simian Immunodeficiency Virus-Induced Alterations in Monocyte Production of Tumor Necrosis Factor Alpha Contribute to Reduced Immune Activation in Sooty Mangabeys

Abstract: g Human immunodeficiency virus type 1 (HIV-1) infection is characterized by persistent viral replication in the context of CD4؉ T cell depletion and elevated immune activation associated with disease progression. In contrast, simian immunodeficiency virus (SIV) infection of African-origin sooty mangabeys (SM) generally does not result in simian AIDS despite high viral loads and therefore affords a unique model in which to study the immunologic contributions to a nonpathogenic lentiviral disease outcome. A key … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

1
8
0

Year Published

2012
2012
2017
2017

Publication Types

Select...
6
3

Relationship

0
9

Authors

Journals

citations
Cited by 14 publications
(9 citation statements)
references
References 56 publications
1
8
0
Order By: Relevance
“…HIV-1 and SIV infection of humans and rhesus macaques, respectively, are associated with chronic immune activation and production of tumor necrosis factor-a from macrophages in response to lipopolysaccharide stimulation. 60 In contrast, in chronically infected sooty mangabeys the macrophage response to lipopolysaccharide is inhibited (Figure 2), a finding consistent with a suppressed chronic immune activation in non-pathogenic infection that is not observed in pathogenic infections.…”
Section: Molecular Basis Of Cross-species Transmissionsupporting
confidence: 66%
“…HIV-1 and SIV infection of humans and rhesus macaques, respectively, are associated with chronic immune activation and production of tumor necrosis factor-a from macrophages in response to lipopolysaccharide stimulation. 60 In contrast, in chronically infected sooty mangabeys the macrophage response to lipopolysaccharide is inhibited (Figure 2), a finding consistent with a suppressed chronic immune activation in non-pathogenic infection that is not observed in pathogenic infections.…”
Section: Molecular Basis Of Cross-species Transmissionsupporting
confidence: 66%
“…Of these, the hallmark characteristic of all natural SIV infections are high levels of SIV replication during both the acute and chronic stages of infection (Brenchley et al, 2012; Diop et al, 2000a; Goldstein et al, 2006; Gordon et al, 2007; Gueye et al, 2004; Kouyos et al, 2010; Onanga et al, 2002, 2006; Pandrea et al, 2005, 2006a, 2008c, 2012a, 2007b; Silvestri et al, 2005; Souquière et al, 2009; Wilks et al, 2011). During the acute infection, the peaks of virus replication in natural hosts are comparable to those seen in untreated HIV-1 and SIVmac infections (Apetrei et al, 2007, 2011; Diop et al, 2000a; Goldstein et al, 2000; Gordon et al, 2007; Gueye et al, 2004; Ma et al, 2013, 2014; Milush et al, 2011; Mir et al, 2012, 2015; Onanga et al, 2002, 2006; Pandrea et al, 2003, 2006a, 2008c, 2012a, 2007b; Schmitz et al, 2012; Silvestri et al, 2005; Souquière et al, 2009; Vanderford et al, 2012). During the chronic infection, VLs in natural hosts tend to be as high or even slightly higher than the VLs seen in pathogenic infections (Pandrea et al, 2006b).…”
Section: Post-transmission Features That May Impact Siv Pathogenesmentioning
confidence: 76%
“…In SM, a reduced monocyte TNF-α response was noted as compared to monocytes from humans and macaque 30 . Moreover, since microbial translocation is not occurring in natural hosts, their monocytes/macrophages are not exposed to LPS [31][32][33] .…”
Section: Monocyte/macrophagesmentioning
confidence: 91%