Simiao Decoction Alleviates Gouty Arthritis by Modulating Proinflammatory Cytokines and the Gut Ecosystem

Lin, Xiaoying; Shao, Tiejuan; Huang, Lin; Wen, Xiaofang; Wang, Mingzhu; Wen, Chengping; He, Zhixing

doi:10.3389/fphar.2020.00955

Cited by 62 publications

(52 citation statements)

References 52 publications

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“…In addition to clinical studies, experimental studies have also suggested the urate lowering effects of Simiao Pills, which act on xanthine oxidase (XO), uric acid transport-related proteins urate anion transporter 1 (URAT1) and glucose transporter 9 (GLUT9), and also modulate the inflammation, oxidative stress and other processes ( Hu et al, 2010 ; Hua et al, 2012 ; Shi et al, 2013 ; Pan et al, 2014 ; Ma et al, 2015 ; Lin et al, 2020 ). The finding suggests that Chinese herbal medicines are mostly multi-targeted or have interplay with other signaling pathways to lower sUA levels.…”

Section: Discussionmentioning

confidence: 99%

The Efficacy and Mechanism of Chinese Herbal Medicines in Lowering Serum Uric Acid Levels: A Systematic Review

et al. 2021

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Background. Chinese herbal medicines are widely used to lower serum uric acid levels. However, no systemic review summarizes and evaluates their efficacies and the underlying mechanisms of action. Objectives. To evaluate the clinical and experimental evidences for the effectiveness and the potential mechanism of Chinese herbal medicines in lowering serum uric acid levels. Methods. Four electronic databases PubMed, Wed of Science, the Cochrane Library and Embase were used to search for Chinese herbal medicines for their effects in lowering serum uric acid levels, dated from 1 January 2009 to 19 August 2020. For clinical trials, randomized controlled trials (RCTs) were included; and for experimental studies, original articles were included. The methodological quality of RCTs was assessed according to the Cochrane criteria. For clinical trials, a meta-analysis of continuous variables was used to obtain pooled effects. For experimental studies, lists were used to summarize and integrate the mechanisms involved. Results. A total of 10 clinical trials and 184 experimental studies were included. Current data showed that Chinese herbal medicines have promising clinical efficacies in patients with elevated serum uric acid levels (SMD: −1.65, 95% CI: −3.09 to −0.22; p = 0.024). There was no significant difference in serum uric acid levels between Chinese herbal medicine treatments and Western medicine treatments (SMD: −0.13, 95% CI: −0.99 to 0.74; p = 0.772). Experimental studies revealed that the mechanistic signaling pathways involved in the serum uric acid lowering effects include uric acid synthesis, uric acid transport, inflammation, renal fibrosis and oxidative stress. Conclusions. The clinical studies indicate that Chinese herbal medicines lower serum uric acid levels. Further studies with sophisticated research design can further demonstrate the efficacy and safety of these Chinese herbal medicines in lowering serum uric acid levels and reveal a comprehensive picture of the underlying mechanisms of action.

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Section: Discussionmentioning

confidence: 99%

The Efficacy and Mechanism of Chinese Herbal Medicines in Lowering Serum Uric Acid Levels: A Systematic Review

et al. 2021

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“…[ 20 ] The findings of Lin suggested that simiao decoction was an effective therapeutic drug for GA and the gut ecosystem might act as a potential anti-inflammatory target of Simiao powder. [ 21 ] Qiu found that simiao powder can significantly improve the symptoms and signs of GA and decrease the levels of UA and CRP. [ 22 ] However, no reports of comparisons simiao powder and acupuncture on GA has been found.…”

Section: Discussionmentioning

confidence: 99%

Traditional Chinese medicine for gouty arthritis

Yao

et al. 2021

Medicine

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Background: Gouty arthritis (GA) is a chronic disease caused by monosodium urate crystal deposition. Repeated attacks of arthritis may lead to the deposition of urate to form gout stone, resulting in joint deformity and joint damage. Although GA is not fatal, it causes low work productivity and low quality of life. Western drug, such as febuxostat, colchicine, allopurinol, often cannot get satisfying curative effect, and may even lead to serious side effects, such as exfoliative dermatitis or uremia. However, the therapeutic effect of Traditional Chinese medicine is very satisfactory. The treatment effect of simiao powder, a Chinese patent medicine, combined with acupuncture was widely used on treatment of GA. Although it has been widely used in clinical practice, its relative effectiveness and safety have not been confirmed. Therefore, this study will use meta-analysis to verify the efficacy and safety of simiao powder combined with acupuncture in the treatment of GA. Methods: All randomized controlled trial of simiao powder combined with acupuncture for the treatment of RA from their inception 29 October, 2020 will be searched form the China National Knowledge Infrastructure, Wanfang Database, Chinese Science and Technology Periodical Database, Chinese Biomedical Literature Database, Pubmed, Embase, Web of Science, and the Cochrane library. Two authors will independently select studies, extract data based on pre-designed inclusion and exclusion criteria. Methodological quality assessment and risk of bias will be assessed using Cochrane bias risk tool. All data analysis will be conducted using Revman5.3, WinBUGS 1.4.3, and Stata14.2 software. Results: We will compare the different outcome indicators of various studies to provide a synthesis of the efficacy and safety of Simiao powder combined with acupuncture for GA patients. The main outcome measures included efficacy, remission rate (no drug symptoms), recurrence rate, clinical absolute score and relative score. Secondary outcome measures included related adverse reactions and uric acid concentration. Conclusion: The findings of the study will provide helpful evidence for the efficacy and safety of simiao powder combined with acupuncture in the treatment of GA. Registration number: This study protocol have been funded through a protocol registry. The registry number is INPLASY2020110028

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“…These findings have supplied insights into novel treatment strategies and approaches for liver fibrosis. For example, the Simiao decoction can reduce inflammatory factor secretion and regulate intestinal flora homeostasis (91). Additionally, a TCM formula was found to reverse increases in scleroderma and Proteobacteria caused by a high-fat diet, resulting in a decreased scleroderma to Bacteroides ratio and an increased abundance of Bacteroides (92).…”

Section: Summary Of the Effects Of Tcm On Liver Fibrosis Through The mentioning

confidence: 99%

Traditional Chinese medicine, liver fibrosis, intestinal flora: is there any connection?—a narrative review

Liu¹,

Qi²,

Sun³

2021

Ann Palliat Med

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This paper aims to analyze how intestinal flora regulates liver fibrosis pathogenesis and to evaluate the regulatory effect of traditional Chinese medicine on the intestinal flora, providing new insights into liver fibrosis treatment. Destruction of the intestinal microbiome can lead to liver fibrosis development, accelerating the intestinal microbiome's disruption. Traditional Chinese Medicine can effectively regulate the intestinal flora, helping prevent and treat liver fibrosis. This review discusses the mechanisms behind intestinal flora changes in liver fibrosis and how traditional Chinese medicine can regulate these changes.We searched PubMed, the Wanfang database, and CNKI for "liver fibrosis", "intestinal microflora", and "intestinal microbiota" and reviewed the retrieved literature. We detail the prevention and treatment options for liver fibrosis though the use of traditional Chinese medicine in regulating intestinal flora. We also highlight the influence of the intestinal flora on liver fibrosis and present the research regarding the prevention and treatment of liver fibrosis using traditional Chinese medicine. We also describe the effects of traditional Chinese medicine on the intestinal flora. Traditional Chinese medicine can effectively regulate the intestinal flora to prevent and treat liver fibrosis through the liver-intestine axis.

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Simiao Decoction Alleviates Gouty Arthritis by Modulating Proinflammatory Cytokines and the Gut Ecosystem

Cited by 62 publications

References 52 publications

The Efficacy and Mechanism of Chinese Herbal Medicines in Lowering Serum Uric Acid Levels: A Systematic Review

The Efficacy and Mechanism of Chinese Herbal Medicines in Lowering Serum Uric Acid Levels: A Systematic Review

Traditional Chinese medicine for gouty arthritis

Traditional Chinese medicine, liver fibrosis, intestinal flora: is there any connection?—a narrative review

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