Similar autobiographical memory impairment in long-term secondary progressive multiple sclerosis and Alzheimer's disease

Müller, Stephan; Saur, Ralf; Greve, Bernhard; Melms, Arthur; Hautzinger, Martin; Fallgatter, A.J.; Leyhe, Thomas

doi:10.1177/1352458512450352

Cited by 37 publications

(46 citation statements)

References 41 publications

(82 reference statements)

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“…Also, this finding of a temporal-graded impairment of autobiographical memory is consistent with the results of many previous studies in aMCI [14,15,18,38]. In addition, we found than in both groups better performance was associated with frequently retrieved episodes, which resulted as better preserved and recalled than those less frequently retrieved.…”

Section: Discussionsupporting

confidence: 82%

“…However, conflicting results have been reported about the presence or absence of a Ribot-like temporal gradient, with some authors reporting a significant temporal-graded amnesia in AD and aMCI [14,15,18] and others reporting no differences in memory recall between remote and recent incidents [19][20][21]. Similarly, signs of semantic RA have been reported in samples of aMCI and AD patients using tests of famous public events [22][23][24][25][26][27] and tests of famous faces or famous names [28][29][30][31][32].…”

Section: Introductionmentioning

confidence: 99%

“…Deficits in remote episodic memory, investigated with autobiographical memory tests such as the Autobiographical Memory Interview [12] and the Autobiographical Interview [13], have been largely documented in patients with aMCI and AD from the early stages of the disease [14][15][16] (for a review, also see [17]). However, conflicting results have been reported about the presence or absence of a Ribot-like temporal gradient, with some authors reporting a significant temporal-graded amnesia in AD and aMCI [14,15,18] and others reporting no differences in memory recall between remote and recent incidents [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

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Retrograde Amnesia for Episodic and Semantic Memories in Amnestic Mild Cognitive Impairment

Simone

Fadda

Perri

et al. 2017

JAD

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Abstract. Retrograde amnesia (RA), which includes loss of memory for past personal events (autobiographical RA) and for acquired knowledge (semantic RA), has been largely documented in patients with amnestic mild cognitive impairment (aMCI). However, previous studies have produced controversial results particularly concerning the temporal extent of memory impairment. Here we investigated whether, with the onset of hippocampal pathology, age of memory acquisition and retrieval frequency play different roles in modulating the progressive loss of semantic and episodic contents of retrograde memory respectively. For this purpose, aMCI patients and healthy controls were tested for the ability to recall semantic and autobiographical information related to famous public events as a function of both age of acquisition and retrieval frequency. In aMCI patients, we found that the impairment in recollecting past personal incidents was modulated by the combined action of memory age and retrieval frequency, because older and more frequently retrieved episodes are less susceptible to loss than more recent and less frequently retrieved ones. On the other side, we found that the loss of semantic information depended only on memory age, because the remoteness of the trace allows for better preservation of the memory. Our results provide evidence that the loss of the two components of retrograde memory is regulated by different mechanisms. This supports the view that diverse neural mechanisms are involved in episodic and semantic memory trace storage and retrieval, as postulated by the Multiple Trace Theory.

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Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Retrograde Amnesia for Episodic and Semantic Memories in Amnestic Mild Cognitive Impairment

Simone

Fadda

Perri

et al. 2017

JAD

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“…Briefly stated, AM is the capacity of reliving detailed events, within their specific spatio-temporal context, as they are remembered [58]. An overview of AM studies in MS [20,21,25,35,37] shows some conflicting results, which seem to rely mainly on some methodological discrepancies, particularly, the sensitivity of the test used to assess AM in MS. The call for a stringent AM test is also motivated by the fact that notwithstanding the variability of AM test performance, MS patients' complaints are frequent.…”

Section: Introductionmentioning

confidence: 99%

Impaired mental simulation of specific past and future personal events in non-depressed multiple sclerosis patients

Ernst

Blanc

Seze

et al. 2014

Journal of the Neurological Sciences

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The aims of the present study were (i) to explore autobiographical memory and episodic future thought in multiple sclerosis (MS), using Levine's Autobiographical Interview; (ii) to investigate the influence of the Interview's high retrieval support condition (the specific probe phase) on MS patients' past and future simulations and (iii) to obtain the patients' estimations of their own difficulties, during the test, and in everyday life. To that end, we examined 39 non-depressed relapsing-remitting MS patients and 34 healthy subjects matched for gender, age and education level. The 73 participants underwent an adapted version of the Autobiographical Interview in two conditions: remembering and imagining personal events. The group of patients also underwent an extended neuropsychological baseline, including particularly, anterograde memory and executive functions. The results showed that the MS patients' scores on the baseline were mildly or not impaired. On the contrary, the Autobiographical Interview measure, i.e., the mean number of internal details, for each of the two phases of the test -free recall and specific probe -was significantly lower in simulated past and future events in comparison with the healthy controls. Within each group, autobiographical memory performance was superior to episodic future thought performance. A strong positive correlation was observed between past and future mental simulation scores in both groups.In conclusion, our results showed, for the first time, the co-occurrence of deficit of remembering the past and imagining the future in MS patients. They also showed more difficulty in imagining future events than remembering past events for both patients and normal controls. MS being a neurological condition very frequent in the young adult population, the clinical considerations of our study might be of interest. Indeed, they give rise to new insights on MS patients' daily life difficulties related to impaired mental simulation of personal events despite general abilities, including anterograde memory, only mildly or not impaired.

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“…Regarding the latter, a more recent line of research has highlighted that retrograde memory, and especially autobiographical memory (AM), is frequently impaired in MS patients Ernst, Blanc, De Seze, et al, 2014;Ernst et al, 2013;Müller et al, 2013). AM corresponds to the ability mentally to re-experience personal detailed events within a specific spatio-temporal context (Tulving, 2002) and it has a pivotal role in daily life functioning, especially for the construction and maintenance of personal identity across time, relationships or goal-directed behaviours (Rasmussen & Habermas, 2011).…”

Section: Introductionmentioning

confidence: 99%

Benefits from an autobiographical memory facilitation programme in relapsing-remitting multiple sclerosis patients: a clinical and neuroimaging study

Ernst

Sourty

Roquet

et al. 2016

Neuropsychological Rehabilitation

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While the efficacy of mental visual imagery (MVI) to alleviate autobiographical memory (AM) impairment in multiple sclerosis (MS) patients has been documented, nothing is known about the brain changes sustaining that improvement. To explore this issue, 20 relapsing-remitting MS patients showing AM impairment were randomly assigned in two groups, experimental (n=10), who underwent the MVI programme, and control (n = 10), who followed a sham verbal programme. Besides the stringent AM assessment, the patients underwent structural and functional MRI sessions, consisting in retrieving personal memories, within a pre-/postfacilitation study design. Only the experimental group showed a significant AM improvement

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Similar autobiographical memory impairment in long-term secondary progressive multiple sclerosis and Alzheimer's disease

Abstract: Our neuropsychological findings suggest that episodic autobiographical memory is affected in long-term patients with SPMS, possibly due to neurodegenerative processes in functional relevant brain regions.

Cited by 37 publications

References 41 publications

Retrograde Amnesia for Episodic and Semantic Memories in Amnestic Mild Cognitive Impairment

Retrograde Amnesia for Episodic and Semantic Memories in Amnestic Mild Cognitive Impairment

Impaired mental simulation of specific past and future personal events in non-depressed multiple sclerosis patients

Benefits from an autobiographical memory facilitation programme in relapsing-remitting multiple sclerosis patients: a clinical and neuroimaging study

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