Similar behaviour of lecithin:cholesterol acyltrans- ferase and pseudocholinesterase in liver disease and hyperlipoproteinemia

Cucuianu, M; Opincaru, A; Tăpălagă, D

doi:10.1016/0009-8981(78)90103-1

Cited by 20 publications

(8 citation statements)

References 21 publications

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“…This appears to be in accordance with Clitherow et al [38] who suggested that the principal function of BChE should be to hydrolyze the acylcholine esters that might arise as by-prod ucts of free fatty acid catabolism and lipogenesis in the liver. Thus, in these cases, BChE might be induced by an accelerated turnover of serum lipids and lipoproteins, as suggested by Cucuianu et al [17], Our findings are very clear in terms of the significant lower mean weight shown by individuals with intense C5 bands. Al though the mean weight of individuals with faint C5 bands did not differ from that of their controls (table 3), a signif icant negative correlation between the C5 band (scores 1-3) and weight variables was shown in this sample (table 1).…”

Section: Discussionsupporting

confidence: 74%

“…Many reports based on studies of its activ ity suggested a role in lipid metabolism. Individuals with higher weight presented higher mean BChE activity [2,13,14], It was shown that subcutaneous fat and BChE activity are positively correlated [15] and that higher mean enzyme activity is presented by obese and hyperlipemic subjects when compared with normal con trols [16][17][18]. A physical association be tween BChE and lipoproteins such as LDL [19][20][21][22][23][24][25] as well as HDL and VHDL [25] has been reported.…”

Section: Introductionmentioning

confidence: 99%

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The C<sub>5</sub> Isozyme of Serum Cholinesterase and Adult Weight

Chautard‐Freire‐Maia¹,

Primo-Parmo²,

Picheth

et al. 1991

Hum Hered

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The relationship between the CHE2 locus of serum cholinesterase (BChE) and adult human weight was studied in a sample of 225 CHE2 C5+ individuals and 225 CHE2 C5- controls matched for sex, height, age and race. With respect to the intensity of the C₅ band staining (scored 1–6), 113 individuals had faint C₅ bands (scores 1–3) and 112 intense C₅ bands (scores 4–6). The individuals with intense CHE2 C5+ phenotype showed a significantly lower mean adult weight (64.66 ± 0.73 kg) when compared to their controls (70.59 ± 0.97 kg) and a significant reduction in weight variance (59.81 and 105.18, respectively). Individuals with faint C₅ bands, although showing a negative correlation between weight and C₅ band intensity, did not differ from their controls in mean weight.

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Section: Discussionsupporting

confidence: 74%

Section: Introductionmentioning

confidence: 99%

The C<sub>5</sub> Isozyme of Serum Cholinesterase and Adult Weight

Chautard‐Freire‐Maia¹,

Primo-Parmo²,

Picheth

et al. 1991

Hum Hered

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“…were noted in two patients with myocardial infarction who also presented the lowest values of pseudocholinesterase (PCE) in this group. Mention should be made that other enzymes secreted by the liver such as lecithin-cholesterol acyl-transferase and fibrin stabilizing factor XIII which are known to decrease in severe liver disease(6,9,26,27) were also found to present a transient fall during the evolution of an acute myocardial infarction(28, 29).On the other side decrease of PCE in postoperative patients was a rather constant finding confirming previous observations (6, 30). Such changes do not necessarily imply a hepatic dysfunction and might be subsequent to the complex readjustment of protein metabolism, accompanying the acute phase reaction.…”

supporting

confidence: 68%

Increased Ristocetin-Cofactor in Acute Myocardial Infarction: a Component of the Acute Phase Reaction

Cucuianu¹,

Missits²,

Olinic³

et al. 1980

Thromb Haemost

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SummaryWhen compared to the values obtained in healthy normal-weight, normolipemic controls, the plasma level of ristocetin-cofactor (VIII: R-cof.) was found to be much higher in patients with acute myocardial infarction and in postoperative conditions (4–5 days after a major surgical intervention). A lesser increase of VIII: R-cof. was noted in atherosclerotic patients without acute occlusive accidents and no significant changes of this plasma factor could be observed in hyperlipemic subjects without obvious clinical atherosclerosis. Serial studies emphasized a tendency towards normalization of plasma VIII: R-cof. as the acute phenomena of a myocardial infarction subsided. The above mentioned data suggest that the high levels of VIII: R-cof. recorded in myocardial infarction are mainly caused by a systemic acute phase reaction and to a lesser extent by endothelial damage. Delayed clearance of VIII: R-cof. subsequent to a hepatic dysfunction or to a modified pattern of protein metabolism during the above mentioned acute phase reaction might also contribute to the high level of this plasma factor.

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“…A striking parallel was also noted between plasma lecithincholesterol acyltransferase and serum BChE activity: both enzymes resulted to be lower than normal in liver disease and higher in endogenous hypertriglyceridemia and were also positively correlated with serum cholesterol and triglycerides, thus suggesting that both liver enzymes might be induced by an increased turnover of serum lipids and lipoproteins [70].…”

Section: Obesity and Metabolic Syndromementioning

confidence: 68%

Butyrylcholinesterase as a prognostic marker: a review of the literature

Santarpia

Grandone

Contaldo

et al. 2012

J cachexia sarcopenia muscle

230

171

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BackgroundButyrylcholinesterase (BChE) is an α-glycoprotein synthesized in the liver. Its serum level decreases in many clinical conditions such as acute and chronic liver damage, inflammation, injury and infections, and malnutrition.Methods and resultsThis review collects the main evidence on the emerging role of butyrylcholinesterase as a prognostic marker of liver and nonliver diseases as well as a marker of protein-energy malnutrition and obesity. In fact, serum concentrations and BChE activity seem to accurately reflect the availability of amino acidic substrates and/or derangement in protein synthesis due to hepatocellular damage. In cancer, with or without liver impairment, serum BChE levels serve as an accurate functional and prognostic indicator, useful for monitoring clinical and therapeutic interventions according to patients’ prognosis. In the absence of inflammation, BChE could also serve as an index of the effectiveness of nutritional support.ConclusionsSerum BChE assessment should be included in routine clinical diagnostic procedures to evaluate patient clinical conditions, in particular in cases of inflammation and/or protein-energy malnutrition.

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Similar behaviour of lecithin:cholesterol acyltrans- ferase and pseudocholinesterase in liver disease and hyperlipoproteinemia

Cited by 20 publications

References 21 publications

The C<sub>5</sub> Isozyme of Serum Cholinesterase and Adult Weight

The C<sub>5</sub> Isozyme of Serum Cholinesterase and Adult Weight

Increased Ristocetin-Cofactor in Acute Myocardial Infarction: a Component of the Acute Phase Reaction

Butyrylcholinesterase as a prognostic marker: a review of the literature

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