Similar cholesterol?lowering properties of rice bran oil, with varied ??oryzanol, in mildly hypercholesterolemic men*

Berger, Alvin; Rein, Dietrich; Schäfer, Angela; Monnard, Irina; Gremaud, G.; Lambelet, Pierre; Bertoli, Constantin

doi:10.1007/s00394-004-0508-9

Cited by 167 publications

(112 citation statements)

References 31 publications

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“…Cholesterol and rice bran oil (998) ; cholesterol absorption and aortic fatty streaks (348,358) ; lipid metabolism (999) ; autonomic nervous unbalance and menopausal troubles (climacteric disturbance) (999,1000) ; anti-ulcerogenic (1001) ; antioxidant (357,360,1002) ; gene expression and oxidative stress (1003) ; glycaemia control (1004,1005) ; platelet aggregation (1006) ; anxiety and stress ulcer (1001,1007 -1009) Avenanthramides: Anti-inflammatory and anti-atherogenic (368) ; smooth muscle cell proliferation and NO production (1010,1011) ; antioxidant (140,367,369) Saponins (370,1012,1013) : Hypercholesterolaemia (173,374,377,1014) ; lipase activity and fat absorption (1015) ; transcriptional activity of Cu,Zn-SOD gene (1016) ; scavenger and superoxides (1017) ; hypoglycaemia (1018,1019) ; gastric emptying rate and glucose transport across the brush border of the small intestine (1018,1020) ; antifungal (374) ; anti-viral (1021) ; diabetes (1022) ; anti-inflammatory (1019) ; anti-carcinogenic (374) ; tumour growth and cytostatic effect (1013,1023 -1027) ; bile acid binding (cited in Mimaki et al (1013) ); cell-mediated immune system and antibody production (375)…”

Section: Appendixmentioning

confidence: 99%

New hypotheses for the health-protective mechanisms of whole-grain cereals: what is beyond fibre?

2010

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Epidemiological studies have clearly shown that whole-grain cereals can protect against obesity, diabetes, CVD and cancers. The specific effects of food structure (increased satiety, reduced transit time and glycaemic response), fibre (improved faecal bulking and satiety, viscosity and SCFA production, and/or reduced glycaemic response) and Mg (better glycaemic homeostasis through increased insulin secretion), together with the antioxidant and anti-carcinogenic properties of numerous bioactive compounds, especially those in the bran and germ (minerals, trace elements, vitamins, carotenoids, polyphenols and alkylresorcinols), are today well-recognised mechanisms in this protection. Recent findings, the exhaustive listing of bioactive compounds found in whole-grain wheat, their content in whole-grain, bran and germ fractions and their estimated bioavailability, have led to new hypotheses. The involvement of polyphenols in cell signalling and gene regulation, and of sulfur compounds, lignin and phytic acid should be considered in antioxidant protection. Whole-grain wheat is also a rich source of methyl donors and lipotropes (methionine, betaine, choline, inositol and folates) that may be involved in cardiovascular and/or hepatic protection, lipid metabolism and DNA methylation. Potential protective effects of bound phenolic acids within the colon, of the B-complex vitamins on the nervous system and mental health, of oligosaccharides as prebiotics, of compounds associated with skeleton health, and of other compounds such as a-linolenic acid, policosanol, melatonin, phytosterols and para-aminobenzoic acid also deserve to be studied in more depth. Finally, benefits of nutrigenomics to study complex physiological effects of the 'whole-grain package', and the most promising ways for improving the nutritional quality of cereal products are discussed. Whole-grain wheat: Bioactive compounds: Physiological mechanisms: Health IntroductionThere is growing evidence that whole-grain cereal products protect against the development of chronic diseases. The most important of these in terms of public health are obesity (1,2) , the metabolic syndrome (3,4) , type 2 diabetes (5,6) , CVD (7) and cancers (8 -12) . Whole-grain cereal consumption has also been shown to be protective against mortality, as was shown with inflammation-related death (i.e. noncardiovascular and non-cancer inflammatory diseases such as, for example, respiratory system diseases) (13) and with cancer and CVD (4,14,15) . These conclusions are supported by the effects of consuming refined cereal products (bread, pasta and rice), as these have been associated with an increased risk of digestive tract, pharynx, larynx and thyroid cancers in northern Italians (16) . However, an association between a lower risk of developing a chronic disease and a high whole-grain cereal consumption does not mean a direct causal relationship and provides no information about the physiological mechanisms involved.These metabolic diseases are related to our daily lifestyle, no...

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Section: Appendixmentioning

confidence: 99%

New hypotheses for the health-protective mechanisms of whole-grain cereals: what is beyond fibre?

2010

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“…phytosterols which again results in lowering of blood cholesterol level. Thus there are efforts being taken to develop RBO retaining its unsaponifiable components, while minimizing levels of problematic free fatty acids 5 . Table 2 shows the cholesterol lowering activity of RBO in comparison with other vegetable oils.…”

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confidence: 99%

Rice Bran Oil: A Versatile Source for Edible and Industrial Applications

Pal

Pratap

2017

J. Oleo Sci.

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“…The hypocholestrolaemic activity of blended oil could be due to the presence of oryzanol (2275.5 ppm) and oleic content (47.6%) of RBO + OO. Oryzanol may inhibit the absorption of cholesterol and may increase the faecal excretion of bile acids [27]. Oleic acid had been described to reduce the cardiovascular risk by reducing blood lipids, mainly cholesterol [28,29].…”

Section: Biochemical Analysismentioning

confidence: 99%

Effect of Blended Rice Bran and Olive Oil on Cardiovascular Risk Factors in Hyperlipidemic Patients

Choudhary¹,

Grover²,

Sangha³

2013

FNS

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The present study was designed to evaluate the effectiveness of blended rice bran and olive oil on hyperlipidemic subjects. A total of 60 moderately hyperlipidemic patients (Total Cholesterol (TC) >200 mg/dl and/or Triglycerides (TG) >150 mg/dl) with an age range of 45 -60 were selected from Mediciti Hospital of Ludhiana and were divided into two groups: Group A and Group B containing 30 subjects each. The subjects of Group B were given blended rice bran and olive oil for a time period of 45 days and were asked to continue with their routine eating and physical activity pattern. The subjects of Group A were kept on their regular cooking oil. The serum lipid values were assessed before and after the study. Additional parameters assessed included anthropometry, dietary fat intake and physical activity pattern. The results showed that there was an insignificant change in the average body mass index (BMI) of the subjects of Group B before (27.0 kg/m 2 ) and after (26.9 kg/m 2 ) the study respectively. Also, there was an insignificant change in the lipid levels of the subjects of Group B after the study. The levels of TC and LDL cholesterol decreased by 3.7 and 9.0 percent respectively. Whereas, the levels of TG and VLDL cholesterol increased by 9.5 percent in the subjects of Group B after the feeding trials. Further, systolic and diastolic blood pressure of the subjects of Group B reduced by 2.9 and 2.3 percent respectively. An insignificant change was observed in all the parameters of selected subjects. So, the present study recommends carrying out more long duration research studies to evaluate the effectiveness of this blended oil.

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Similar cholesterol?lowering properties of rice bran oil, with varied ??oryzanol, in mildly hypercholesterolemic men*

Cited by 167 publications

References 31 publications

New hypotheses for the health-protective mechanisms of whole-grain cereals: what is beyond fibre?

New hypotheses for the health-protective mechanisms of whole-grain cereals: what is beyond fibre?

Rice Bran Oil: A Versatile Source for Edible and Industrial Applications

Effect of Blended Rice Bran and Olive Oil on Cardiovascular Risk Factors in Hyperlipidemic Patients

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