Similar decreases in local tumor control are calculated for treatment protraction and for interruptions in the radiotherapy of carcinoma of the larynx in four centers

Robertson, Chris; Robertson, Anne S.; Hendry, Jolyon H; Roberts, Stephen A; Slevin, Nicholas J; Duncan, W.; MacDougall, R.H.; Kerr, G.R.; O’Sullivan, Brian; Keane, Thomas J.

doi:10.1016/s0360-3016(97)00716-5

Cited by 136 publications

(81 citation statements)

References 20 publications

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“…Treatment related parameters that may have an effect on end results include overall treatment time (OTT) [6,16,27,33,40,41,42,49,51], fraction size [20,22,29,43,54] [42]. Even with surgical salvage, the group of patients whose treatment was most prolonged had an increased risk of death from loco-regional progression of disease.…”

Section: Discussionmentioning

confidence: 99%

Three weeks radiotherapy for T1 glottic cancer: the Christie and Royal Marsden Hospital Experience

Gowda¹,

Henk²,

Mais³

et al. 2003

Radiotherapy and Oncology

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Section: Discussionmentioning

confidence: 99%

Three weeks radiotherapy for T1 glottic cancer: the Christie and Royal Marsden Hospital Experience

Gowda¹,

Henk²,

Mais³

et al. 2003

Radiotherapy and Oncology

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“…CT should be resumed when every organ failure is resolved and no sign of SIRS is present. Conversely, the radiotherapeutical systemic effects are less dangerous than chemotherapeutical ones: consequently, the panel suggests continuing RT as the advantage due to local-toxicity recovering could be annulled by the negative effects of tumor re-growth [106,107]. Of course, the symptoms of local toxicity must be monitored/controlled.…”

Section: Rt Interruptionmentioning

confidence: 99%

Sepsis in head and neck cancer patients treated with chemotherapy and radiation: Literature review and consensus

Mirabile

Numico²,

Russi

et al. 2015

Critical Reviews in Oncology/Hematology

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The reporting of infection/sepsis in chemo/radiation-treated head and neck cancer patients is sparse and the problem is underestimated. A multidisciplinary group of head and neck cancer specialists from Italy met with the aim of reaching a consensus on a clinical definition and management of infections and sepsis. The Delphi appropriateness method was used for this consensus. External expert reviewers then evaluated the conclusions carefully according to their area of expertise. The paper contains seven clusters of statements about the clinical definition and management of infections and sepsis in head and neck cancer patients, which had a consensus. Furthermore, it offers a review of recent literature in these topics

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“…Unplanned breaks in radiotherapy for head and neck cancer are associated with significantly worse locoregional control [10,11,13]. There is evidence that even a short break may have negative conse- quences; in a retrospective analysis of 2,225 patients from four centers [11], an unplanned break of only 1 day resulted in a 0.68% lower 2-year local control rate. Other authors have estimated that the tumor control rate is at least 1% lower for every day that radiation treatment is interrupted [4,6].…”

Section: Clinical Consequences Of Radiation Treatment Breaksmentioning

confidence: 99%

Radiation Treatment Breaks and Ulcerative Mucositis in Head and Neck Cancer

et al. 2008

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Unplanned radiation treatment breaks and prolongation of the radiation treatment time are associated with lower survival and locoregional control rates when radiotherapy or concurrent chemoradiotherapy is used in the curative treatment of head and neck cancer. Treatment of head and neck cancer is intense, involving high-dose, continuous radiotherapy, and often adding chemotherapy to radiotherapy. As the intensity of treatment regimens has escalated in recent years, clinical outcomes generally have improved. However, more intensive therapy also increases the incidence of treatment-related toxicities, particularly those impacting the mucosal lining of the oral cavity, pharynx, and cervical esophagus, and results in varying degrees of ulcerative mucositis. Ulcerative mucositis is a root cause of unscheduled radiation treatment breaks, which prolongs the total radiation treatment time. Alterations in radiotherapy and chemotherapy, including the use of continuous (i.e., 7 days/week) radiotherapy to ensure constant negative proliferative pressure, may improve efficacy outcomes. However, these approaches also increase the incidence of ulcerative mucositis, thereby increasing the incidence of unplanned radiation treatment breaks. Conversely, the reduction of ulcerative mucositis to minimize unplanned breaks in radiotherapy may enhance not only tolerability, but also efficacy outcomes. Several strategies to prevent ulcerative mucositis in radiotherapy for head and neck cancer have been evaluated, but none have demonstrated strong efficacy. Continued investigation is needed to identify superior radiation treatment regimens, technology, and supportive care that reduce unplanned radiation treatment breaks with the goal of improving clinical outcomes in head and neck cancer. The Oncologist 2008;13:886 -898

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Similar decreases in local tumor control are calculated for treatment protraction and for interruptions in the radiotherapy of carcinoma of the larynx in four centers

Cited by 136 publications

References 20 publications

Three weeks radiotherapy for T1 glottic cancer: the Christie and Royal Marsden Hospital Experience

Three weeks radiotherapy for T1 glottic cancer: the Christie and Royal Marsden Hospital Experience

Sepsis in head and neck cancer patients treated with chemotherapy and radiation: Literature review and consensus

Radiation Treatment Breaks and Ulcerative Mucositis in Head and Neck Cancer

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