This prospective study was conducted to investigate electrophysiological qualities and patient's satisfaction of a synovial gliding tissue flap in treating true recurring carpal tunnel syndrome. In 14 patients (11 women, three men), 15 median nerves were included in this retrospective study. For all 15 nerves, motor and sensory nerve conduction velocity, compound muscle action potential, a Visual Analogue Scale-score (VAS-score) questionnaire and an adapted Levine-Test were evaluated pre-and postoperatively. All participants underwent operative neurolysis of the median nerve, which was then enwrapped by a synovial gliding tissue flap. Eleven procedures were completed by integument enlargement. Follow-up period was 12 months. Postoperatively, distal latency decreased significantly by 15.6%. Compound muscle action potential and sensory nerve conduction velocity did not improve significantly. VAS score regarding pain reduced highly significantly with 74.1%. The adapted Levine-Test function score improved highly significantly with 39.2%. The synovial gliding tissue flap lead to an excellent patient's satisfaction for treating true recurring carpal tunnel syndrome. Primary wound closure should be completed with integument enlargement if needed. Author Contributions: Conceptualization, S.P. and E.T.; methodology, S.P. and E.T.; validation, T.M.T., E.T. and V.M.; formal analysis, S.P.; E.T. and V.M.; investigation, S.P. and E.T.; resources, V.M.; data curation, S.P. and E.T.; writing-original draft preparation, S.P.; E.T.; writing-review and editing, V.M. and T.M.T.; visualization, V.M., E.T. and T.M.T.; project administration, T.M.T.; funding acquisition, no funding. Funding: This research received no external funding.
Conflicts of Interest:The authors declare no conflict of interest.