Similar Impact of Psoriatic Arthritis and Rheumatoid Arthritis on Objective and Subjective Parameters of Hand Function

Abstract

Objective. The objective of this study was to compare the impact of psoriatic disease (psoriatic arthritis [PsA] and psoriasis) and rheumatoid arthritis (RA) on objective and subjective parameters of hand function. Methods. Hand function was determined in this cross-sectional study by 1) vigorimetric grip strength, 2) the Moberg Picking-Up Test used for assessing fine-motor skills, and 3) self-reported hand function (Michigan Hand Questionnaire). Mixed-effects linear regression models were used to test the relation of hand function with disease group, age, and sex. Results. Two hundred ninety-nine subjects were tested, 101 with RA, 92 with PsA, and 106 nonarthritic controls (51 with psoriasis and 55 healthy controls [HCs]). Regression analysis showed that hand function was influenced by age, sex, disease group, and hand dominance (P < 0.001 for all). The impact of PsA and RA on hand function was comparable and generally more pronounced in women. Both PsA and RA led to significantly enhanced age-related loss of grip strength, fine-motor skills, and self-reported hand function in patients with PsA and RA compared with HCs. In addition, patients with psoriasis showed significant impairment of hand function compared with HCs. Conclusion. RA and PsA have a comparable impact on the decline of strength, fine-motor skills, and self-reported function of the hand. Unexpectedly, patients with psoriasis also show impaired hand function that follows a similar pattern as observed in patients with PsA.

Evaluation of Optical and Radar Based Motion Capturing Technologies for Characterizing Hand Movement in Rheumatoid Arthritis—A Pilot Study

“…The here applied marker set up introduced by [16] allows the extraction of hand movement characteristics and also proved applicable in our patient cohort. Patients performed generally worse in grip strength and MPUT tests when compared to healthy individuals as expected and previously shown [8]. This impaired functionality is also reflected in the here presented kinematic data.…”

“…Additionally, these functional measures even though they are objective, often are not well related with the above mentioned subjective patient reported outcome measures and do not provide a resolution for discrepancies between clinical scores and subjective patient reported disease activity. Age and sex both affect subjective and objective clinical hand function outcomes in RA patients as we have shown in a recent study [8]. In light of the state-of-the-art treatment options for RA patients, a detailed and early quantification and detection of disease activity is desirable, see [9], to allow personalized treatment regiments and amend currently used subjective patient reported outcome measures.…”

POS1475-HPR THE MINIMALLY IMPORTANT DIFFERENCE AS THE INTERPRETABILITY OF EMOTIONAL HEALTH DOMAIN IN JAPANESE VERSION OF LupusPRO FOR SLE PATIENTS; PRELIMINARY RESULTS OF A PROSPECTIVE COHORT STUDY

“…The MID for improvement was estimated at 12.3 using the anchor-based method, and the cutoff point corresponded to 9.3 [95%CI -6.7 to 25.3]) of the EH change score by the receiver operating curve method. Conclusion: In this study, the MID (3 months) for the EH domain in the Japanese version of LupusPRO was estimated to be between 9 and 12, which was similar to the results of the previous cross-sectional study3) . The challenge in estimating the MID in our setting was the low correlation with external anchors, even though the study population was limited to patients with low disease activity, because disease activity at baseline can generally influence 'improved' health status.…”

“…Coppers 1,2 , S. Heinrich 3 , U. Phutane 3 , D. Berisha 3 , K. Tascilar 1,2 , A. Kleyer 1,2 , D. Simon 1,2 , J. Bräunig 4 , J. Penner 3 , M. Vossiek 4 , V. Schönau 1,2 , S. Bayat 1,2 , G. Schett 1,2 , S. Leyendecker 3 , A. M. Liphardt 1,2 . 1 Friedrich-Alexander-Universität Erlangen-Nürnberg and University Hospital Erlangen, Department of Internal Medicine 3-Rheumatology and Immunology, Erlangen, Germany; 2 Friedrich-Alexander-Universität Erlangen-Nürnberg and University Hospital Erlangen, Deutsches Zentrum für Immuntherapie, Erlangen, Germany; 3 Friedrich-Alexander-Universität Erlangen-Nürnberg, Chair of Applied Dynamics, Erlangen, Germany; 4 Friedrich-Alexander-Universität Erlangen-Nürnberg, Institute of Microwaves and Photonics, Erlangen, Germany Background: Physical function is an important factor determining disease burden in arthritis. Monitoring function in rheumatoid arthritis (RA) patients is essential for effective treatment [1].…”

“…The currently used tools to assess physical function (e.g. patient reported outcomes) have limitations with respect to sensitivity and specificity to measure functional impairment in RA [2,3]. A marker-based optoelectronic measurement of hand function enables detailed analysis of hand movements such as spatial-temporal parameters and joint angles [4].…”