Similar Levels of Disease Severity Correspond to a Greater Burden of Illness in Women Compared with Men with Hidradenitis Suppurativa

Samela, Tonia; Dattolo, Anna; Cordella, Giorgia; Antinone, Valeria; Mastroeni, Simona; Fusari, Roberta; Fania, Luca; Abeni, Damiano

doi:10.2340/actadv.v103.2558

Cited by 5 publications

(3 citation statements)

References 12 publications

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“…In this study, Sampogna et al (2008) found a significant difference in Skindex-29 scores, with worse outcomes for women in items #2, #6, #11, #12, #13, #15, #26, #28, and for the whole emotions and functioning subscale (p < 0.05), but not for the symptom's subscale. This result is in accordance with previous research on gender differences in chronic autoimmune dermatology patients (Samela et al, 2023).…”

Section: Differences Among Genders Detected In Skin Disease Quality O...supporting

confidence: 93%

Gender differences in vitiligo: psychological symptoms and quality of life assessment description

Samela,

Malorni,

Matarrese

et al. 2023

Front. Psychol.

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ObjectiveAssuming that the difference exist in the manifestation of psychological suffering among genders, the purpose of this review is to summarize the current knowledge on gender differences in vitiligo quality of life and psychological assessment.MethodsWe searched in PubMed, Scopus, and Web of Science databases for original articles in English language. Results were screened according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA checklist).ResultsThe study yielded 107 results; 12 articles have been evaluated as eligible. Each eligible study has been screened and analyzed. The study’s qualitative evaluation revealed that 8 papers were classifiable as satisfactory, 4 were classifiable as unsatisfactory. The agreement between the coders was high (% agreement = 84.6%; Cohen’s kappa = 0.79). All considered researches (100%) were cross-sectional studies, based on self-report questionnaires. From our analysis, women with vitiligo had a higher risk to experience lower quality of life, and worse mental health in a wide range of psychopathology symptoms than men. A wide heterogeneity of tools is used to investigate the quality of life and psychological symptoms among these patients.ConclusionUnfortunately, there are few explanatory models proposed in the literature to rationalize these findings. It will be important to investigate in further researches the specific influence of known risk factors for psychopathology in this population to better explore these phenomena.

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Section: Differences Among Genders Detected In Skin Disease Quality O...supporting

confidence: 93%

Gender differences in vitiligo: psychological symptoms and quality of life assessment description

Samela,

Malorni,

Matarrese

et al. 2023

Front. Psychol.

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“…It is notable that, in that study, the findings were independent of HS severity ( 2 ). HS may be a very embarrassing disease with serious consequences, and patients with HS, especially females, consider the burden of HS to be very high ( 22 ), and have also been reported to have an increased risk of suicide regardless of whether they have a previous psychiatric diagnosis ( 23 ).…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Characteristics of Hidradenitis Suppurativa in the Northern Finland Birth Cohort 1986 Study: A Cross-sectional Study of 2,775 Subjects

Sinikumpu,

Jokelainen,

Huilaja

2024

Acta Derm Venereol

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A negative stigmatization related to hidradenitis suppurativa may prevent patients from seeking care. Thus, a large proportion of patients with hidradenitis suppurativa may be missing from studies based on hospital data. The aim of this study was to examine the prevalence and characteristics of hidradenitis suppurativa among 2,775 subjects in the Northern Finland Birth Cohort 1986 Study (NFBC1986), who were in their mid-thirties. The prevalence of hidradenitis suppurativa was 4.0% (n = 110/2,775), being higher in females (4.8%) than in males (2.5%) (p < 0.01). Of those defined as having hidradenitis suppurativa in this study, only 4 cases (n = 4/110, 3.6%) were found to have a hidradenitis suppurativa diagnosis either in the hospital (Care Register for Health Care) or in the primary healthcare data. In an adjusted model in logistic regression analyses, hidradenitis suppurativa was significantly associated with obesity (body mass index 30–55 kg/m2) (odds ratio 3.81, 95% confidence interval 2.80–5.22), female sex (1.99, 1.53–2.61) and smoking (1.56, 1.21–2.00). In addition, there was an association between hidradenitis suppurativa and self-reported poor overall health status. Hidradenitis suppurativa seems to be common at the population level and only a minority of these patients seek care for the condition.

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“…As stated by the position statement of the European Academy of Dermatology and Venereology task forces on Quality of Life and Patient-Oriented Outcomes (12), among the specialty-specific PROMS, HS illness load has been predominantly assessed by the Dermatology Life Quality Index (DLQI), the Skindex-17, and the Skindex- 29 (13-15). Some recent studies are stressing the idea that the level of disease severity does not always correspond to the same illness load in HS measured with different PROMS (16)-as already highlighted for other chronic skin conditions (17,18)-and the idea that HS is a very debilitating condition, even at lower levels of clinical severity (15). Regardless of disease severity, as measured with the International Hidradenitis Suppurativa Severity Score System (IHS4) (19), patients with HS often go through the disruption of their personal and social life because of their disease (i.e., especially because of pain, suppuration, and discomfort due to abscesses), as documented by scores obtained in Skindex-17 subscales (15).…”

Section: Introductionmentioning

confidence: 99%

Item-specific patterns of the Skindex-17 in individuals with different levels of Hidradenitis Suppurativa severity: a network analysis study

Raimondi,

Samela,

Fania

et al. 2023

Front. Public Health

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BackgroundRecent studies are stressing the idea that the level of Hidradenitis Suppurativa (HS) severity does not always correspond to the same illness load. In fact, it was found that there was no significant association between Skindex-17 and clinical severity of HS, and that some items of the Skindex-17 might be more related to HS severity than others.ObjectiveThe aim of the current study was to explore the associations between different levels of clinical severity of HS (mild, moderate, severe) and the Skindex-17 single-item responses in a large sample of adults patients.MethodsA cross-sectional study with a sample include 547 consecutive HS patients, approaching for the first time the specific dermatologic evaluation. Eligible criteria included age ≥ 18 years, HS diagnosis formulated contextually by the same expert clinician, and providing informed consent. All participants completed the Skindex-17 and were evaluated for the disease clinical severity with the International Hidradenitis Suppurativa Severity Score System. A Network Analysis was conducted, which represents a powerful methodological approach in clinical research. It allows to study specific patterns and the structure of complex system in order to better understand how the elements of the system interact with each-other. Three different Network Analyses were conducted for each group of HS clinical severity by including the items of the Skindex-17 as the nodes of each network.ResultsAmong 547 patients, 40% (219) were female and mean age was of 32.70 (±11.41). Different patterns among items of the Skindex-17 for the three clinical severity groups emerged, meaning that in each group different items are more crucial than others. The psychosocial subscale of the Skindex-17 is the most relevant when assessing the Quality of Life of individuals with different levels of HS severity, however, with the progression of the disease, individuals place attention also on two different aspects of the symptoms subscale of the Skindex-17, irritation and pain, which in turn perfectly reflect the severity of HS, from a clinical perspective.ConclusionThese results provide new insights on the association between levels of HS severity and related Quality of Life, measured with the Skindex-17.

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Similar Levels of Disease Severity Correspond to a Greater Burden of Illness in Women Compared with Men with Hidradenitis Suppurativa

Abstract: is missing (Short communication)

Cited by 5 publications

References 12 publications

Gender differences in vitiligo: psychological symptoms and quality of life assessment description

Gender differences in vitiligo: psychological symptoms and quality of life assessment description

Prevalence and Characteristics of Hidradenitis Suppurativa in the Northern Finland Birth Cohort 1986 Study: A Cross-sectional Study of 2,775 Subjects

Item-specific patterns of the Skindex-17 in individuals with different levels of Hidradenitis Suppurativa severity: a network analysis study

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