Similar to adiponectin, serum levels of osteoprotegerin are associated with obesity in healthy subjects

A comparison of osteoprotegerin with adiponectin and high-sensitivity C-reactive protein (hsCRP) as a marker for insulin resistance

“…Our group has previously shown in a rigorously-defined healthy population (all had a normal OGTT and exercise stress test to exclude dysglycaemia and ischaemic heart disease respectively) that OPG correlates negatively with HOMA-IR (r = − 0.222, P < .05), suggesting that increasing insulin resistance in a healthy population is associated with lower serum OPG [16]. Other papers which are in agreement with this finding of a negative association between OPG and IR were published by Ugur-Altun and colleagues in 2 separate studies [17,18].…”

The effect of bariatric surgery on serum TRAIL and osteoprotegerin levels in obesity complicated by glucose disorders

“…In contrast, others have shown that circulating TRAIL levels relate positively with increased body fat and serum lipids not only in the elderly [18], but are also positively associated with fat mass and central obesity in healthy weight [19]. In sedentary individuals, increased TRAIL levels have been linked to a higher energy intake and balance [20], though some controversy exists [19].…”

Association of Obestatin, Ghrelin, and Inflammatory Cytokines in Obese Patients with Non-alcoholic Fatty Liver Disease

“…For example, IL-7 is known to suppress expression of several molecules known to promote the pathogenesis of Fig. 2 Low circulating IL-7 can hypothetically increase susceptibility to DM or hepatic fibrosis by a number of mechanisms including and allowing increased activity of pathogenic molecules and/or failure to stimulate the expression of molecules capable of suppressing the development of diabetes type 2 and/or liver fibrosis fibrosis and DM, such as TNFRSF11b [3]. Additionally, IL-7 stimulates either the expression or the activity of SMAD7 that protect against fibrosis through inhibition of ECM production [42].…”