Similarities, differences, and possible interactions between hepatitis E and hepatitis C viruses: Relevance for research and clinical practice

Marascio, Nadia; Rotundo, Salvatore; Quirino, Angela; Matera, Giovanni; Liberto, Maria Carla; Costa, Chiara; Russo, Alessandro; Trecarichi, Enrico Maria; Torti, Carlo

doi:10.3748/wjg.v28.i12.1226

Cited by 5 publications

(3 citation statements)

References 92 publications

(120 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Modified Child-Pugh's classification. 1 Scoring system: 5-6 points, grade A; 7-9 points, grade B; 10-15 points, grade C. 2 HE: hepatic encephalopathy; Grade 0: sub-clinical hepatic encephalopathy, SHE, unraveled by Retain tests A or B; Grade 1: anxiety, irritability, depression, impaired concentration, sleep disturbances; Grade 2: disorientation, poor short-term memory, disinhibited behavior, drowsiness; Grade 3: somnolence, bizarre behavior, confusion, amnesia, paranoia; Grade 4: Coma. 3 PT, Prothrombin Time, also expressed in seconds prolonged < 4; 4-6; > 6.…”

Section: Blood Sampling and Analysismentioning

confidence: 99%

“…It comprises autoimmune hepatitis, both of which induce ongoing liver damage. There are over 350 million chronic HBV carriers, nearly 71 million people infected with HCV and 20 million people infected with HEV worldwide 1 . Persistent damage to the liver may trigger liver cirrhosis (LC), i.e., a stage of partial loss of liver structure and function and potentially life-threatening complications 2 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Serum ApoB/ApoA1 ratio in patients with CHB and the occurrence of HBV related cirrhosis and HBV related hepatocellular carcinoma

Cai,

Peng,

Xiao

et al. 2024

Sci Rep

View full text Add to dashboard Cite

Clinical research has suggested that chronic HBV infection exerts a certain effect on the occurrence of cardiovascular disease by regulating cholesterol metabolism in liver cells. High serum apolipoprotein B/apolipoprotein A1 (ApoB/ApoA1) ratio plays a certain role in the above regulation, and it serves as a risk factor for cardiovascular disease. However, whether the ApoB/ApoA1 ratio is correlated with chronic HBV infection and its disease progression remains unclear. In accordance with the inclusion and exclusion criteria, all 378 participants administrated at Renmin Hospital of Wuhan University from March 2021 to March 2022, fell into Healthy Control (HC) group (50 participants), Hepatocellular carcinoma (HCC) group (107 patients), liver cirrhosis (LC) group (64 patients), chronic hepatitis B (CHB) group (62 patients), chronic hepatitis C (CHC) group (46 patients) and Hepatitis E Virus (HEV) group (49 patients). Serum ApoA1 and ApoB concentrations were measured at admission, and the ApoB/ApoA1 ratio was determined. The levels of laboratory parameters in the respective group were compared and ApoB/ApoA1 ratios in HCC patients and LC patients with different severity were further analyzed. ROC curves were plotted to analyze the early diagnostic ability of ApoB/ApoA1 ratio for HBV-associated HCC. Logistic regression and restricted cubic spline analysis were used to explore the correlation between ApoB/ApoA1 ratio and LC and HCC risk. A comparison was drawn in terms of ApoB/ApoA1 ratio between the groups, and the result was expressed in descending sequence: HEV group > CHB group > LC group > HCC group > CHC group > HC group, early-stage HCC < middle-stage HCC < advanced-stage HCC, Class A LC < Class B LC < Class C LC. Serum ApoB/ApoA1 ratio combined diagnosis with AFP exhibited the capability of increasing the detection efficacy and specificity of AFP for HCC and AFP-negative HCC. The incidence of LC and HCC in the respective logistic regression model showed a negative correlation with the serum ApoB/ApoA1 ratio in CHB patients (P < 0.05). After all confounding factors covered in this study were regulated, the result of the restricted cubic spline analysis suggested that in a certain range, serum ApoB/ApoA1 ratio showed an inverse correlation with the prevalence of LC or HCC in CHB patients. Serum ApoB/ApoA1 ratio in CHB patients may be conducive to identifying high-risk patients for HCC or LC, such that LC and HCC can be early diagnosed and treated.

show abstract

Section: Blood Sampling and Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Serum ApoB/ApoA1 ratio in patients with CHB and the occurrence of HBV related cirrhosis and HBV related hepatocellular carcinoma

Cai,

Peng,

Xiao

et al. 2024

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Due to repair with connective tissue, the excessive hepatic necrosis accompanied by an excessive decomposition of the extracellular matrix (ECM) developing cirrhosis -which is the final stage of the fibrotic process characterized by permanent hepatocyte damage, nodular regeneration, aberrant architecture and mostly accompanied by scar tissue formation that impairs hepatocyte function and impaired portal blood flow-CH can progress into liver cancer or death. [19][20][21][22][23]…”

Section: Chronic Hepatitismentioning

confidence: 99%

Viral hepatitis, hallmarks and molecular features

Vargas-Sierra,

Camara-Medina,

Vincze-Galicia

et al. 2023

psrua

View full text Add to dashboard Cite

Hepatitis is a liver inflammation which has different etiologies, it can be caused pharmacologically or can be associated with fatty liver or alcohol consumption. However, viral infection as the most important cause. Recently, the World Health Organization (WHO) has published reports of outbreaks of hepatitis of unknown etiology in several countries in children less than 16 years. In this review we describe the general aspects of viral hepatitis, the molecular description of the hepatotropic viruses, laboratory findings, molecular diagnosis, prevention strategies. In addition, the main characteristics of some viruses that are not hepatotropic but have been previously reported to be related to some types of hepatitis are mentioned. Finally, a brief description of new cases of hepatitis of unknown origin is given and the adverse effects of SARS COV-2 vaccines are briefly discussed.

show abstract

Co-infection of hepatitis E virus, Clonorchis sinensis, and Escherichia coli: A case report

Zhang

Wang

Zhang

et al. 2023

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

Hepatitis E virus (HEV) is a common cause of acute hepatitis that threatens human health worldwide. With the popularization of detection technology, the reports of hepatitis E have gradually increased. Here, we present a rare case of co-infection with hepatitis E viruses, Clonorchis sinensis and Escherichia coli. A 52-year-old man was hospitalized because of fatigue, jaundice, and nausea for more than 2 weeks. Laboratory tests showed elevated bilirubin, aminotransferase (ALT), and aspartate aminotransferase (AST); HEV-IgM was positive, and HEV-RNA could be detected. Moreover, parasites were found in the biliary drainage and the biliary culture, which suggested Escherichia coli. The patient was effectively treated with praziquantel, imipenem, and hepatoprotective drugs and his clinical symptoms were relieved after 2 months; total bilirubin decreased to 85.1 μmol/L, ALT decreased to 92.4 U/L, and AST decreased to 102 U/L.

show abstract

Similarities, differences, and possible interactions between hepatitis E and hepatitis C viruses: Relevance for research and clinical practice

Cited by 5 publications

References 92 publications

Serum ApoB/ApoA1 ratio in patients with CHB and the occurrence of HBV related cirrhosis and HBV related hepatocellular carcinoma

Serum ApoB/ApoA1 ratio in patients with CHB and the occurrence of HBV related cirrhosis and HBV related hepatocellular carcinoma

Viral hepatitis, hallmarks and molecular features

Co-infection of hepatitis E virus, Clonorchis sinensis, and Escherichia coli: A case report

Contact Info

Product

Resources

About