Similarity of multicomponent nanomaterials in a safer-by-design context: the case of core–shell quantum dots

Abstract

Concepts of similarity applied to complex multicomponent advanced materials for an informed balance of performance and hazard.

Advanced materials earliest assessment (AMEA)

“…2 reflect case studies that have been categorized according to the AMEA initial questions (Table SI_1†). Since the present AMEA conceptualization precedes the demonstration, only one case study is published yet, 64 and all others are in the process of being evaluated against the design principles and of being screened with methods recommended for the lab phase by Table 1 and Fig. 3.…”

“…68–70 The recommendation (Table 1) to apply similarity tools & rankings to assess if AdMa versions are significantly different from each other and from CoMa was implemented by Di Battista et al by testing of biodissolution and surface reactivity on a family of ZnCuInS–ZnS variations, benchmarked against pure CuO. 64 Additionally, reactivity was tested on the release-adjusted doses of the pure Cu, In, Zn ions, to fulfill also the recommendation to perform tests on released entities (Table 1). One reactivity test with potential AdMa interference (DCFH is among the recommended assays but relies on fluorescence) 71 was excluded.…”