Simmondsia chinensis: A rich source of bioactive flavonoids and lignans

Abdel‐Mageed, Wael M.; Bayoumi, Soad A.H.; Radwan, A E; Salem‐Bekhit, Mounir M.; Abd-Alrahman, Sherif H.; Basudan, Omer A.; Sayed, Hanaa M.

doi:10.1016/j.indcrop.2014.06.007

Cited by 12 publications

(7 citation statements)

References 34 publications

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“…Long-term administration of lower doses of simmondsins induces a sustained food intake inhibition of approximately 20% in rats without any toxic effects . As a part of our continuing interest in searching for drug leads from natural sources, we had the opportunity to continue the work on jojoba leaf constituents to investigate its chemical constituents and their potential biological activities …”

supporting

confidence: 83%

Noncyanogenic Cyanoglucoside Cyclooxygenase Inhibitors from Simmondsia chinensis

et al. 2016

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Two new noncyanogenic cyanoglucoside dimers, simmonosides A and B (1 and 2), were identified from the aqueous extract of jojoba (Simmondsia chinensis) leaves. Compounds 1 and 2 are the first examples of noncyanogenic cyanoglucoside dimers containing a unique four-membered ring, representing novel dimerization patterns at α,β-unsaturated carbons of a nitrile group in 1 and γ,δ-unsaturated carbons in 2. Their structures were elucidated based on spectroscopic evidence and electronic circular dichroism (ECD) calculations. Compounds 1 and 2 exhibit promising COX-2 inhibition activity, with IC50 values of 13.5 and 11.4 μM, respectively.

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supporting

confidence: 83%

Noncyanogenic Cyanoglucoside Cyclooxygenase Inhibitors from Simmondsia chinensis

et al. 2016

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“…It is constituted of eicosanoic acid (66% to 71%), docosanoic acid (14% to 20%), and oleic acid (10% to 13%). Jojoba oil also contains ceramides and flavonoids (Abdel‐Mageed and others ) and vitamin E, which acts as an antioxidant and protects the skin against free radicals (Jaafar and others ). The jojoba oil microcapsules presented controlled release over time when diffusing of jojoba oil, microencapsulated onto compression garment, through a pig skin (Jaafar and others ).…”

Section: Benefits Of Oils and Their Encapsulationmentioning

confidence: 99%

Microencapsulation of Oils: A Comprehensive Review of Benefits, Techniques, and Applications

Bakry

Abbas

Ali

et al. 2015

Comp Rev Food Sci Food Safe

705

415

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Microencapsulation is a process of building a functional barrier between the core and wall material to avoid chemical and physical reactions and to maintain the biological, functional, and physicochemical properties of core materials. Microencapsulation of marine, vegetable, and essential oils has been conducted and commercialized by employing different methods including emulsification, spray-drying, coaxial electrospray system, freeze-drying, coacervation, in situ polymerization, melt-extrusion, supercritical fluid technology, and fluidized-bed-coating. Spray-drying and coacervation are the most commonly used techniques for the microencapsulation of oils. The choice of an appropriate microencapsulation technique and wall material depends upon the end use of the product and the processing conditions involved. Microencapsulation has the ability to enhance the oxidative stability, thermostability, shelf-life, and biological activity of oils. In addition, it can also be helpful in controlling the volatility and release properties of essential oils. Microencapsulated marine, vegetable, and essential oils have found broad applications in various fields. This review describes the recognized benefits and functional properties of various oils, microencapsulation techniques, and application of encapsulated oils in various food, pharmaceutical, and even textile products. Moreover, this review may provide information to researchers working in the field of food, pharmacy, agronomy, engineering, and nutrition who are interested in microencapsulation of oils.

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“…Indepth chemical analysis is still required in order to gain insight into the active molecule or molecules. A comprehensive work was performed by Abdel-Mageed et al, identifying flavonoid aglycones from the ethanolic leaf extract of jojoba (Abdel-Mageed et al 2014). Quercetin 3-methyl ether (isorhamnetin), quercetin 3,3-dimethylether, and quercetin showed strong antioxidant activity and lipoxygenase inhibition (Fig.…”

Section: Antioxidant Capacitymentioning

confidence: 99%

“…This may be linked to the ability of the plant extract and simmondsin to inhibit with high potency both lipoxygenase (LOX) and cyclooxygenase (COX), key enzymes in the inflammation cascade. LOX and COX are responsible mainly for the metabolism of arachidonic acid, generating its downstream signaling and inflammatory mediators, such as prostaglandins, leukotrienes and lipid peroxidation by products (Cohen et al 2013;Abdel-Mageed et al 2014. Furthermore, jojoba leaf extracts at as low as EC 50 2 µg/ml have been reported to present an anti-viral effect on herpes simplex viruses type 1 and 2 (HSV-1, HSV-2) and varicella-zoster virus (Yarmolinsky et al 2010).…”

Section: Additional Medicinal Values and The Future Of Jojoba Researchmentioning

confidence: 99%

Medicinal properties of jojoba (Simmondsia chinensis)

Tietel

Kahremany

Cohen

et al. 2021

Israel J. Plant Sci.

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Jojoba, Simmondsia chinensis (Link) C.K. Schneider is an evergreen shrub widely grown in Israel, the Middle East, South America, Africa, India and Australia used as an agricultural crop for commercial purposes and as a source of its non-edible natural wax. It is widely used in pharmaceutics and cosmetic formulation due to its unique structural characteristics and beneficial health effects. In addition, extensive work has been published on the plant’s health-promoting activities, ranging from antioxidant activities to the treatment of cancer. Being a rich source of natural liquid wax, the majority of research regarding jojoba focuses on its applications, as well as on the ability to exploit the residual plant materials obtained in its production. To date, several potent phytochemicals have been attributed to its medicinal properties, e.g. simmondsin and phenolic compounds. The current review emphasizes the evidence-based medicinal qualities of the wax and plant extracts and highlights the gaps of knowledge in these research areas and the importance of acquiring additional understanding of jojoba distinctive traits.

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Simmondsia chinensis: A rich source of bioactive flavonoids and lignans

Cited by 12 publications

References 34 publications

Noncyanogenic Cyanoglucoside Cyclooxygenase Inhibitors from Simmondsia chinensis

Noncyanogenic Cyanoglucoside Cyclooxygenase Inhibitors from Simmondsia chinensis

Microencapsulation of Oils: A Comprehensive Review of Benefits, Techniques, and Applications

Medicinal properties of jojoba (Simmondsia chinensis)

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