Simple and accurate measurement of carbamazepine in surface water by use of porous membrane-protected micro-solid-phase extraction coupled with isotope dilution mass spectrometry

Teo, Hui Ling; Wong, Lingkai; Liu, Qinde; Teo, Tang Lin; Lee, Tong Kooi; Lee, Hian Kee

doi:10.1016/j.aca.2016.01.028

Cited by 26 publications

(6 citation statements)

References 45 publications

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“…Many of these compounds cannot be fully removed by these plants and they are discharged in surface water, raising concerns about their potential ecotoxicological effects [1,2,3]. One of the pharmaceuticals frequently detected in the aquatic environment is carbamazepine (CBZ), also known as Tegratol and Epitol, which is a prescription drug used extensively in the clinical treatment of epilepsy, trigeminal neuralgia, and other psychiatric disorders [1,4,5,6]. Carbamazepine was detected in the environment with concentrations ranging from ng/L up to µg/L [1,7,8].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Fe- and Co-Doped TiO2 with Improved Photocatalytic Activity Under Visible Irradiation Toward Carbamazepine Degradation

et al. 2019

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Pure TiO2 and Fe- and Co-doped TiO2 nanoparticles (NPs) as photocatalysts were synthesized using wet chemical methods (sol-gel + precipitation). Their crystalline structure and optical properties were analyzed using X-ray diffraction (XRD), Raman spectroscopy and Fourier-transform infrared (FTIR) spectroscopy, ultraviolet-visible light (UV-Vis) diffuse reflectance spectroscopy (DRS), and photoluminescence (PL) spectroscopy. The photocatalytic activity of the synthesized nanoparticles was evaluated through degradation of carbamazepine (CBZ) under UV-A and visible-light irradiations. The XRD and Raman analyses revealed that all synthesized nanomaterials showed only the anatase phase. The DRS results showed that the absorption edge was blue-shifted for Fe-doped TiO2 NPs. The decrease in charge recombination was evidenced from the PL investigation for both Co-doped and Fe-doped TiO2 nanomaterials. An enhancement in photocatalytic degradation of carbamazepine in aqueous suspension under both UV-A light and visible-light irradiations was observed for Fe-doped Titania NPs by comparison with pure TiO2. These results suggest that the doping cations could suppress the electron/hole recombination. Therefore, the photocatalytic activity of TiO2-based nanomaterials was enhanced.

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Section: Introductionmentioning

confidence: 99%

Synthesis of Fe- and Co-Doped TiO2 with Improved Photocatalytic Activity Under Visible Irradiation Toward Carbamazepine Degradation

et al. 2019

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“…Based on this descriptive information, the highest occurrences are seen for fluoxetine and carbamazepine compounds in runoff waters (12%) and trimethoprim (17%) and carbamazepine (26%) in wastewater and surface waters; these compounds are commonly used as antiepileptics and antidepressants. In the case of carbamazepine, which presents the greatest occurrences, its presence in all type of aquatic matrices has been previously reported [36,37]; its presence is related to incomplete metabolism in the body, excessive use by people and its persistence in the environment [35,36].…”

Section: Results and Analysismentioning

confidence: 95%

“…The results by the type of water evaluated show that the highest occurrences are seen for fluoxetine and carbamazepine compounds in runoff waters (12%) and trimethoprim (17%) and carbamazepine (26%) in wastewater and surface waters; these compounds are commonly Endocrine Disruptors used as antiepileptics and antidepressants. In the case of carbamazepine, which presents the greatest occurrences, its presence in all type of aquatic matrices has been previously reported [36,37]; its presence is related to incomplete metabolism in the body, excessive use by people Occurrence of Endocrine Disruptor Chemicals in the Urban Water Cycle of Colombia http://dx.doi.org/10.5772/intechopen.78325 and its persistence in the environment [35,36]. Pharmaceutical compounds again behave similarly in terms of occurrence and concentration in both wastewater and surface water, Figure 7 shows this behavior.…”

Section: Endocrine Disruptorsmentioning

confidence: 83%

Occurrence of Endocrine Disruptor Chemicals in the Urban Water Cycle of Colombia

Bedoya-Ríos¹,

Lara-Borrero²

2018

Endocrine Disruptors

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In developing countries such as Colombia, information on the occurrence of endocrine disruptors is still incipient. Bogotá, the capital of Colombia, has a complexity at an anthropogenic and environmental level that makes it particularly important to determine the possible presence of this type of compounds and the risks associated with its presence in aquatic environments. During the present study, the occurrence of endocrine disruptors, mainly pharmaceuticals, plasticizers, and hormones in different aquatic matrices including wastewater, surface water, runoff water, and drinking water was evaluated; the results show that phthalates present the highest occurrence followed by bisphenol A, with an important participation of carbamazepine (0.68-31.45 μgL À1 ), the most commonly found compound is bis(2-ethylhexyl) phthalate (BEHP). It was also found in the drinking water, this leads to the conclusion that endocrine disruptors in Colombia and Bogotá are a reality and deserve attention from researchers to deepen their potential sources of generation and control strategies, as well as the provision must start generating policies in this regard.

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“…In present study, we developed a reliable isotope dilution HPLC‐HESI‐MS/MS method for accurate determination of TIF in plasma and different tissues of tilapia. Isotope dilution combined with mass spectrometry has been recognized as a primary method to establish a traceable and highly accurate method for the measurement of the amount of substances, because it is the preferred approach to reducing matrix interference from labeled analogs for each target analyte (Du et al, 2012; Teo et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics, bioavailability, and tissue disposal profiles of Tiamulin fumarate in Nile tilapia (Oreochromis niloticus) following oral and intravenous administrations

Liu

Cao

Song

et al. 2021

Vet Pharm & Therapeutics

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Tiamulin fumarate (TIF) is a pleuromutilin antibiotic and has high activity against animal bacterial pathogens including aquatic bacterial pathogens. However, its pharmacokinetic profiles, tissue distribution characteristics and bioavailability in aquatic animals remain unknown. The objective of this study was to investigate the pharmacokinetics and tissue distribution regularities of TIF in tilapia (Oreochromis niloticus) following a single oral (PO) dose of 20 mg/kg body weight (bw) and a single intravenous (IV) dose of 5 mg/kg bw at 22 ± 1°C, respectively. TIF concentrations in tilapia plasma and tissues were determined using the isotope dilution HPLC‐HESI‐MS/MS procedure, which was validated according to the guidelines defined by US Food and Drug Administration. TIF was well distributed throughout the body compartments of tilapia judged by the apparent volume of distribution (Vd) >1 L/kg (6.69 L/kg PO and 1.78 L/kg IV). TIF had a short mean residence time (MRT; 22.82 h PO and 14.61 h IV) and quick total body clearance (CLb) (0.62 L kg−1 h−1 PO and 0.60 L kg−1 h−1 IV). The total area under the curve (AUCtot) of plasma were 32.25 μg h−1 ml−1 (PO) and 8.30 μg h−1 ml (IV), respectively, and the oral absolute bioavailability (F%) of TIF was calculated to be approximately 97.1%. For tissue distribution, high concentrations of TIF were found in kidney, and the longest MRT was recorded in bile. The withdrawal time (WT) of TIF in muscle, skin, liver, kidney, gill, and bile was 3.75 (4) and 1.79 (2), 1.77 (2) and 2.06 (3), 6.41 (7) and 1.97 (2), 6.95 (7) and 3.98 (4), 4.92 (5) and 2.36 (3), and 7.06 (8) and 6.16 (7) days after PO and IV administration, respectively. The present investigations indicated that TIF was quickly absorbed, well distributed, rapidly eliminated in tilapia, and it could serve as reference data for establishing use regimen and provide useful information for the further development of TIF in aquaculture.

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Simple and accurate measurement of carbamazepine in surface water by use of porous membrane-protected micro-solid-phase extraction coupled with isotope dilution mass spectrometry

Cited by 26 publications

References 45 publications

Synthesis of Fe- and Co-Doped TiO2 with Improved Photocatalytic Activity Under Visible Irradiation Toward Carbamazepine Degradation

Synthesis of Fe- and Co-Doped TiO2 with Improved Photocatalytic Activity Under Visible Irradiation Toward Carbamazepine Degradation

Occurrence of Endocrine Disruptor Chemicals in the Urban Water Cycle of Colombia

Pharmacokinetics, bioavailability, and tissue disposal profiles of Tiamulin fumarate in Nile tilapia (Oreochromis niloticus) following oral and intravenous administrations

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