Simple and configural association learning in rats with bilateral quisqualic acid lesions of the nucleus basalis magnocellularis

Butt, Allen E.; Hodge, Gordon K.

doi:10.1016/s0166-4328(97)00062-4

Cited by 26 publications

(28 citation statements)

References 64 publications

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“…Importantly, none of the treatments in the present study had any significant effect on acquisition of the CA task. The CA task incorporates many of the same motivational factors that drive performance on the DMP task, namely food deprivation and reward; however, in contrast to spatial tasks which, in rodents, rely heavily on hippocampal circuits, the CA task appears to rely more heavily on projections to frontal cortex (Butt and Hodge, 1997;Butt et al, 2002;Rudy and Sutherland, 1995). The fact that no significant treatment effects were observed on acquisition of the CA task indicates that all groups were equally willing to work for food reward and suggests that the effects of estradiol and testosterone on the DMP task are not due to differences in motivation.…”

Section: Discussionmentioning

confidence: 99%

Testosterone and estradiol produce different effects on cognitive performance in male rats

Gibbs

2005

Hormones and Behavior

100

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The effects of castration and hormone treatment on cognitive performance were evaluated in male rats. Castrated animals received either testosterone or estradiol and were compared with gonadally intact animals and with castrated controls. Results revealed a dissociation between the effects of testosterone and estradiol on cognitive performance in male rats. Specifically, estradiol enhanced acquisition of a delayed matching-to-position spatial task, similar to previously published observations in females. In contrast, neither castration nor testosterone treatment had any significant effect on acquisition of the delayed matching-to-position task, but did appear to affect delay-dependent working memory. None of the treatments had any significant effect on acquisition of a configural association negative patterning task, suggesting that effects on the delayed matching-to-position task were not due to effects on motivational factors. These data demonstrate that, as in females, gonadal hormones influence cognitive performance in males and suggest that estradiol and testosterone affect distinct cognitive domains.

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Section: Discussionmentioning

confidence: 99%

Testosterone and estradiol produce different effects on cognitive performance in male rats

Gibbs

2005

Hormones and Behavior

100

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“…In contrast, Butt and co-workers have reported that either excitotoxic lesions of the NBM, or selective cholinergic lesions of the NBM using 192IgG-SAP, can significantly impair acquisition of a negative patterning task, without producing impairment on a similar transverse patterning task (Butt and Bowman, 2002;Butt and Hodge, 1997;Butt, Noble, Rogers, and Rea, 2002). There are several possible explanations for the disagreement between these results.…”

Section: Effects On Ca Acquisitionmentioning

confidence: 93%

Cholinergic lesions produce task-selective effects on delayed matching to position and configural association learning related to response pattern and strategy

Gibbs

Johnson

2007

Neurobiology of Learning and Memory

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Abstract192 IgG-saporin (SAP) was used to selectively destroy cholinergic neurons in the rostral basal forebrain (e.g., medial septum (MS) and vertical limb of the diagonal band of Broca (VDB)) and/or the caudal basal forebrain (e.g., nucleus basalis magnocellularis (NBM)) of ovariectomized SpragueDawley rats. The effects of these lesions on two different cognitive tasks, a delayed matching to position (DMP) T-maze task, and a configural association (CA) operant conditioning task, were evaluated and compared. Injecting SAP into either the MS or NBM significantly impaired acquisition of the DMP task. Analysis showed that the effects were due largely to an affect on response patterns adopted by the rats during training, as opposed to an effect on working memory performance. Notably, the impairment in DMP acquisition did not correlate with the degree of cholinergic denervation of the hippocampus. Despite the deficit, most animals eventually learned the task and reached criterion; however by the end of training, controls and animals that received SAP into either the MS or NBM appeared more likely to use an allocentric place strategy to solve the task, whereas animals that received SAP into both the MS and NBM were more likely to use an egocentric response strategy. Cholinergic lesions also produced a small but significant affect on acquisition of the CA task, but only with respect to response time, and only in the SAP-NBM-treated animals. SAP-NBM lesions also produced small but significant impairments in both the number of responses and response time during the acquisition of simple associations, possibly reflecting an effect on alertness or attention. Notably, the effects on CA acquisition were small, and like the effects on DMP acquisition did not correlate with the degree of cholinergic denervation of the hippocampus. We conclude that selective basal forebrain cholinergic lesions produce learning deficits that are task specific, and that cholinergic denervation of either the frontal cortex or hippocampus can affect response patterns and strategy in ways that affect learning, without necessarily reflecting deficits in working memory performance.

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“…In that study we hypothesized that the cholinergic system in turtles would be involved in the learning of the negative patterning problem because nitric oxide cells are found in close proximity to cholinergic cells in the basal forebrain of turtles (Bruning, Wiese, & Mayer, 1994). As described above, acquisition of negative patterning has been shown to be impaired in rats after lesions of the cholinergic basal forebrain (Butt & Hodge, 1997;Butt et al, 2002). In addition, impairment on negative patterning has been found in rats after blockade of muscarinic cholinergic receptors with scopolamine (P. M. Moran, 1992;Richmond et al, 1997).…”

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confidence: 97%

“…Butt and coworkers (Butt & Hodge, 1997;Butt, Noble, Rogers, & Rea, 2002) proposed that the basal forebrain cholinergic system mediates configural learning but not elemental learning, and they supported this notion with data showing that lesions of the basal forebrain cholinergic cells made by 192 IgG-saporin lesions, which destroy cholinergic cells but leave other cells intact, impair negative patterning acquisition in rats but not elemental discrimination (Butt et al, 2002). These authors also postulated a role for attention in the configural learning deficits seen after lesions of the cholinergic system: they suggested that learning about the compound requires attention to both elements simultaneously, and if animals were impaired in their ability to attend, they would show configural learning impairments.…”

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confidence: 99%

Role of acetylcholine in negative patterning in turtles (Chrysemys picta).

Powers¹,

Hogue²,

Lynch³

et al. 2009

Behavioral Neuroscience

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Turtles were run on a negative patterning task involving 2 positive elements, a key with white stripes on a black background, and a solid red key, and a compound stimulus combining the 2 elements, white stripes on a red background. Injections of scopolamine, methylscopolamine, or saline were started at the same time that the compound stimulus was introduced, after the animals had been autoshaped to press the key for each of the elements. Scopolamine disrupted the learning of negative patterning, but methylscopolamine had no effect. In contrast, learning of a simple discrimination between the elements was not affected by scopolamine. These results show that muscarinic cholinergic receptors are involved in the learning of negative patterning in turtles.

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Simple and configural association learning in rats with bilateral quisqualic acid lesions of the nucleus basalis magnocellularis

Cited by 26 publications

References 64 publications

Testosterone and estradiol produce different effects on cognitive performance in male rats

Testosterone and estradiol produce different effects on cognitive performance in male rats

Cholinergic lesions produce task-selective effects on delayed matching to position and configural association learning related to response pattern and strategy

Role of acetylcholine in negative patterning in turtles (Chrysemys picta).

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