Simple and easy method for measurement of ambulatory activity in mice

Hirabayashi, Makizo; Iizuka, Masahiro; Tadokoro, Sakutaro

doi:10.1254/fpj.74.629

Cited by 54 publications

(15 citation statements)

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“…The effective doses of MK-801 that produced a significant increase in the mouse's activity were almost comparable to those reported by Clineschmidt et al (7). However, it is unlikely that MK 801-induced ataxia was non-specifically in volved in the ambulation-increment, because the ambulometer used in this experiment de tected ambulatory movements of longer than 15 cm as 1 count, and a small movement such swinging of the body was completely neglected (12).…”

Section: The Coadministrationsupporting

confidence: 84%

Characteristics of the Ambulation-Increasing Effect of the Noncompetitive NMDA Antagonist MK-801 in Mice: Assessment by the Coadministration with Central-Acting Drugs.

Kuribara¹,

Asami

Ida

et al. 1992

Jpn.J.Pharmacol

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ABSTRACT-Characteristics of the ambulation-increasing effect of MK-801, a non competitive NMDA antagonist, were assessed through the coadministration of MK 801 with various central-acting drugs in mice. The MK-801 (0.3 mg/kg, i.p.)-induced ambulation-increment with a slight ataxia was maximum at around 50 min, and ambulation returned to the control level at about 3 hr after the administration. At 1 mg/kg, the mouse's activity transiently increased, followed by a decrease due to a marked ataxia, which was due to neither stereotypy nor convulsion, for 20-50 min, and then increased again; the ambulation-increment continued even at 4 hr after the administration. Coadministration of MK-801 (0.3 mg/kg, i.p.) with either methampheta mine (2 mg/kg, s.c.), cocaine (20 mg/kg, s.c.), GBR-12909 (10 mg/kg, i.p.), scopol amine (0.5 mg/kg, s.c.), caffeine (10 mg/kg, s.c.) or morphine (10 mg/kg, s.c.) pro duced a significant enhancement of the effect. However, 0.1 mg/kg of MK-801 had no effect on the interaction with these drugs. On the other hand, the ambulation-increas ing effect of MK-801 (0.3 mg/kg) was significantly reduced by haloperidol (0.03 and 0.1 mg/kg, s.c.), ceruletide (0.01 and 0.1 mg/kg, i.p.), reserpine (0.05 and 2 mg/kg, s.c., pretreatment 4 hr before) and nimodipine (1 and 3 mg/kg, i.p.), but it was scarcely modified by a-methyl-p-tyrosine (100 and 200 mg/kg, i.p., pretreatment 24 hr and 4 hr before), imipramine (20 mg/kg, i.p.), 6R-L-erythro-5,6,7,8-tetrahydro-bio pterin (100 mg/kg, i.p.), pilocarpine (1 and 4 mg/kg, s.c.), N6-(L-2-phenylisopropyl) adenosine (0.03 and 0.1 mg/kg, s.c.) and naloxone (1 and 5 mg/kg, s.c.). These re sults indicate the MR-801 increases the mouse's ambulatory activity through stimula tion of the dopaminergic system which is strongly affected by a calcium-dependent mechanism.The noncompetitive NMDA antagonist MK 801, (+)-5-methyl-10,11-dihydro-5H-dibenzo [a,d]cyclohepten-5,10-imine (1), has been re ceiving much attention in behavioral pharma cology as a tool for assessing the role of the central neurotransmission systems of the NMDA-component.It has been reported that MK-801 shows anticonvulsant action (2), neuroprotective ac tion (3), an antiparkinson property (4), and anticonflict action (5, 6). Furthermore, Clineschmidt et al. (7) demonstrated that MK

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Section: The Coadministrationsupporting

confidence: 84%

Characteristics of the Ambulation-Increasing Effect of the Noncompetitive NMDA Antagonist MK-801 in Mice: Assessment by the Coadministration with Central-Acting Drugs.

Kuribara¹,

Asami

Ida

et al. 1992

Jpn.J.Pharmacol

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“…The ambulatory activity of each mouse was measured by a tilting-type ambulometer (AMB-10, O'Hara & Co.) (10). Mice were individually placed in the Plexiglas activ ity cages and adapted to the cages for 30 min, and then the ambulatory activity was measured for 1.5 hr after the administration of ketamine (12.5, 25 and 50 mg/kg) or sa line.…”

mentioning

confidence: 99%

The Repeated Administration of Ketamine Induces an Enhancement of Its Stimulant Action in Mice

Uchihashi¹,

Kuribara²,

Morita

et al. 1993

Japanese Journal of Pharmacology

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ABSTRACT-The modification of the stimulant and motor-incoordinate actions of ketamine induced by repeated administration was investigated by means of ambulatory activity and rota-rod performance in mice, respectively. Ketamine (12.5, 25 and 50 mg/kg, s.c.) increased the mouse's ambulation in a dose dependent manner, and the repeated 5-times administration at 3 to 4-day intervals enhanced the increment effect. However, a disruption of the rota-rod performance by ketamine was not modified by the repeated treatment. These results suggest that a reverse tolerance to the stimulant action of ketamine is produced, and that a tolerance to its motor-incoordinate action may not cause the enhancement.

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“…The principle and properties for the measurement were published in detail by Hirabayashi et al (10). Sixteen activity cages of the same type with a field 25 cm in diameter and 13 cm in height were used simultaneously.…”

Section: Methodsmentioning

confidence: 99%

Enhancement of motor-accelerating effect induced by repeated administration of methamphetamine in mice: Involvement of environmental factors.

Alam

1981

Jpn.J.Pharmacol

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Abstract-Adult male mice were given 2.0 mg/kg of methamphetamine hydrochloride (MAM) for 6 times at 3-4 day intervals.The acute effects of MAM on locomotor activity of each mouse were investigated for 180 min after each administration.The motor-accelerating effect of MAM was progressively enhanced in parallel to the number of administrations. However, the enhancement of effect was not observed after repeated administration of MAM, when the mice were placed individually in narrow jars, which thereby perfectly inhibited ambulation during 180 min following each administration.The other mice were trained under the discriminated shuttle-type avoidance schedule (intertrial interval= 25 sec, CS presen tation= 5 sec and 1 session= 1 hr). A slight influence of training on locomotor activity was detected after 2.0 mg/kg of MAM in the activity cage. A marked enhancement of the motor-accelerating effect was detected in the avoidance-trained mice, when 2.0 mg/kg of MAM was given for 5 times at 3-4 day intervals in the avoidance situation.These results suggest that the conditioned drug effect in association with environmental factors plays an important role in the production of enhancement.

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Simple and easy method for measurement of ambulatory activity in mice

Cited by 54 publications

References 0 publications

Characteristics of the Ambulation-Increasing Effect of the Noncompetitive NMDA Antagonist MK-801 in Mice: Assessment by the Coadministration with Central-Acting Drugs.

Characteristics of the Ambulation-Increasing Effect of the Noncompetitive NMDA Antagonist MK-801 in Mice: Assessment by the Coadministration with Central-Acting Drugs.

The Repeated Administration of Ketamine Induces an Enhancement of Its Stimulant Action in Mice

Enhancement of motor-accelerating effect induced by repeated administration of methamphetamine in mice: Involvement of environmental factors.

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