Simple and Effective Protocol for Claisen-Schmidt Condensation of Hindered Cyclic Ketones with Aromatic Aldehydes

Abstract

A simple and effective methodology for ClaisenSchmidt condensation of (-)-menthone and other hindered cyclic ketones with aromatic aldehydes under highly basic conditions using a polar aprotic solvent and a strong base (alkali metal hydroxide or an alkoxide) is described and discussed.

Carbon sphere templates for TiO 2 hollow structures: Preparation, characterization and photocatalytic activity

“…A plausible explanation of the phenomenon can be the following: Sucrose first undergoes dehydration reaction resulting HMF (5-(hydroxymethyl)-2-furaldehyde) which then take part in polymerization and aldol condensation reactions [32,33,42]. It is reported that aldol reaction of cyclic and aromatic ketones/aldehydes are more favorable under alkaline conditions [43]. Thus, this may lead to faster accumulation of polymerized species which eventually results rapid nucleation.…”

Rapid screening method to study the reactivity of UV filter substances towards skin proteins by high‐performance thin‐layer chromatography

“…As 4-MBC was no longer commercially available, it was synthesized according to a previously published method [34]. Briefly, camphor (9.13 g, 60 mmol) and 4-methylbenzaldehyde (7.21 g, 60 mmol) were suspended in 100 mL DMSO, and finely ground potassium hydroxide (3.4 g, 60 mmol) was added by degrees.…”

Unusual pathway of alkylation of 2-(4-bromobenzylidene)-p-menthan-3-one with ethyl bromoacetate

“…Results on the research of the absolute and relative configuration of compounds of the 1 series are in details reported in paper. 11 In conclusion, the reaction of enolate carbanion of 2 (4 bromobenzylidene) p menthan 3 one with ethyl bromoacetate selectively proceeds as the О alkylation. We failed in finding the literature examples of alkylation of 2 arylidenecyclohexanones with haloacetic acid esters.…”

“…Br (1) C (11) endo and exocyclic double bonds is slightly disturbed (torsion angle С(2)-С(1)-С(6)-С (7) is -162.8(2)°). Bromophenyl substituent is in ар conformation relatively to the С(1)-С (6) There is no reason for the change of the С(5) chiral center configuration during the transformations described.…”