Simple and facile preparation of recombinant human bone morphogenetic protein-2 immobilized titanium implant via initiated chemical vapor deposition technique to promote osteogenesis for bone tissue engineering application

Youn, Yun Hee; Lee, Sang Jin; Choi, Go Ro; Lee, Hak Rae; Lee, Dong-Hyun; Heo, Dong Nyoung; Kim, Byung Soo; Bang, Jae Beum; Hwang, Yu‐Shik; Correlo, Vítor M.; Reis, Rui L.; Im, Sung Gap; Kwon, Il Keun

doi:10.1016/j.msec.2019.03.048

Cited by 47 publications

(22 citation statements)

References 52 publications

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“…For improving the biocompatiblity of the titanium implants commonly used in bone repair and joint replacement, the GMA units were successfully functionalized with a protein that promote rapid healing of damage boned tissue. 159 The epoxy moieties of GMA were also successfully employed to immobilize polyethyleneimine, as a blanket or patterned layer, to provide an adhesion site for lentivirus. 160 Patterned viral functionalized surfaces allowed for site-specific delivery of viral genes to cultured human tissue.…”

Section: Biotechnologymentioning

confidence: 99%

Nanoscale control by chemically vapour-deposited polymers

Gleason

2020

Nat Rev Phys

104

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Section: Biotechnologymentioning

confidence: 99%

Nanoscale control by chemically vapour-deposited polymers

Gleason

2020

Nat Rev Phys

104

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“…Besides, Otsuka et al (2016) clarified that due to the acceleration of dissolution at the interface, the delamination life of the HA coating immersed in the simulated body fluid (SBF) is shortened. Therefore, the delamination behavior of FIGURE 1 | Surface treatment methods with their advantages, disadvantages, and applications (Vahabzadeh et al, 2015;Asri et al, 2017;Azari et al, 2019;Chouirfa et al, 2019;Kaur and Singh, 2019;Souza et al, 2019;Thangavel et al, 2019;Youn et al, 2019;Xia et al, 2020). extracorporeal circulation should be considered to extend the service life of HA coatings.…”

Section: Plasma Spray Technologymentioning

confidence: 99%

“…Hence, in the research of Park et al (2015), dot-patterned GMA-coated titanium implants notably displayed higher ALP activities, while displayed increased protein adsorption and higher calcium deposition. Furthermore, based on the previous study, Youn et al (2019) added recombinant human bone morphogenic protein-2 (rhBMP2) as osteoinductive agents on GMA-coated titanium. From in vitro analysis, they found its good osteogenic activity without any cytotoxicity.…”

Section: Chemical Vapor Depositionmentioning

confidence: 99%

“…From in vitro analysis, they found its good osteogenic activity without any cytotoxicity. Scarce information exists on the effect of amino group (Du et al, 2016;Youn et al, 2019) Good controlling on composition and characteristics of the film, flexibility plasma-enhanced CVD on nerve regeneration. Hence, Zhao et al (2018) introduced the amino group onto the titanium disk.…”

Section: Chemical Vapor Depositionmentioning

confidence: 99%

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Surface Modification Techniques of Titanium and its Alloys to Functionally Optimize Their Biomedical Properties: Thematic Review

Xue

Attarilar

Liu

et al. 2020

Front. Bioeng. Biotechnol.

146

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Depending on the requirements of specific applications, implanted materials including metals, ceramics, and polymers have been used in various disciplines of medicine. Titanium and its alloys as implant materials play a critical role in the orthopedic and dental procedures. However, they still require the utilization of surface modification technologies to not only achieve the robust osteointegration but also to increase the antibacterial properties, which can avoid the implant-related infections. This article aims to provide a summary of the latest advances in surface modification techniques, of titanium and its alloys, specifically in biomedical applications. These surface techniques include plasma spray, physical vapor deposition, sol-gel, micro-arc oxidation, etc. Moreover, the microstructure evolution is comprehensively discussed, which is followed by enhanced mechanical properties, osseointegration, antibacterial properties, and clinical outcomes. Future researches should focus on the combination of multiple methods or improving the structure and composition of the composite coating to further enhance the coating performance.

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“…In addition, XPS was used to determine the Ca/P, O/P, and O/Ca ratios for all samples after their immersion in SBF, confirming the formation of HA [ 68 ]. Using XPS, insights into the chemical interactions during the formation of the coating can be gained, which is crucial for understanding the final performance of the coating [ 69 , 70 , 71 ]. De Santis et al [ 69 ] used XPS to analyze Ti implant samples with TNT-Ce n (n = 1, 3, 6, 9, and 12, based on the number of depositions) coatings.…”

Section: Interaction and Morphology Studiesmentioning

confidence: 99%

Analytical Techniques for the Characterization of Bioactive Coatings for Orthopaedic Implants

Kravanja

Finšgar

2021

Biomedicines

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The development of bioactive coatings for orthopedic implants has been of great interest in recent years in order to achieve both early- and long-term osseointegration. Numerous bioactive materials have been investigated for this purpose, along with loading coatings with therapeutic agents (active compounds) that are released into the surrounding media in a controlled manner after surgery. This review initially focuses on the importance and usefulness of characterization techniques for bioactive coatings, allowing the detailed evaluation of coating properties and further improvements. Various advanced analytical techniques that have been used to characterize the structure, interactions, and morphology of the designed bioactive coatings are comprehensively described by means of time-of-flight secondary ion mass spectrometry (ToF-SIMS), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR), atomic force microscopy (AFM), scanning electron microscopy (SEM), transmission electron microscopy (TEM), 3D tomography, quartz crystal microbalance (QCM), coating adhesion, and contact angle (CA) measurements. Secondly, the design of controlled-release systems, the determination of drug release kinetics, and recent advances in drug release from bioactive coatings are addressed as the evaluation thereof is crucial for improving the synthesis parameters in designing optimal bioactive coatings.

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Simple and facile preparation of recombinant human bone morphogenetic protein-2 immobilized titanium implant via initiated chemical vapor deposition technique to promote osteogenesis for bone tissue engineering application

Cited by 47 publications

References 52 publications

Nanoscale control by chemically vapour-deposited polymers

Nanoscale control by chemically vapour-deposited polymers

Surface Modification Techniques of Titanium and its Alloys to Functionally Optimize Their Biomedical Properties: Thematic Review

Analytical Techniques for the Characterization of Bioactive Coatings for Orthopaedic Implants

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