Simple and rapid gas—liquid chromatographic method for estimating carbamazepine in serum

Cocks, D.A.; Dyer, Terence F; Edgar, Kevin J.

doi:10.1016/s0378-4347(00)84154-7

Cited by 7 publications

(3 citation statements)

References 9 publications

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“…The gaseous compounds being analyzed interact with the walls of the column, which is coated with a stationary phase. This causes each compound to elute at a different time, known as the retention time of the compound [8] , [9] , [10] , [11] , [12] .…”

Section: Gcmentioning

confidence: 99%

Quantitative bioanalytical and analytical method development of dibenzazepine derivative, carbamazepine: A review

Datar¹

2015

Journal of Pharmaceutical Analysis

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Bioanalytical methods are widely used for quantitative estimation of drugs and their metabolites in physiological matrices. These methods could be applied to studies in areas of human clinical pharmacology and toxicology. The major bioanalytical services are method development, method validation and sample analysis (method application). Various methods such as GC, LC–MS/MS, HPLC, HPTLC, micellar electrokinetic chromatography, and UFLC have been used in laboratories for the qualitative and quantitative analysis of carbamazepine in biological samples throughout all phases of clinical research and quality control. The article incorporates various reported methods developed to help analysts in choosing crucial parameters for new method development of carbamazepine and its derivatives and also enumerates metabolites, and impurities reported so far.

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Section: Gcmentioning

confidence: 99%

Quantitative bioanalytical and analytical method development of dibenzazepine derivative, carbamazepine: A review

Datar¹

2015

Journal of Pharmaceutical Analysis

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“…Immunological procedures are often biased by molecules with similar structure and according to our knowledge no immunological method developed thus far can properly distinguish between CBZ and CBZE [4]. Chromatographic methods [5,6] enable the simultaneous determination of CBZ and CBZE but require sample preparation, expensive columns and large amounts of organic solvents. During the last two decades, capillary electrophoresis (CE) has gained growing interest and popularity among separation methods due to its high separation power, rapid analysis time, and ease of operation.…”

Section: Introductionmentioning

confidence: 99%

Determination of carbamazepine and carbamazepine-10,11-epoxide in human serum and plasma by micellar electrokinetic capillary chromatography in the absence of electroosmosis

Kuldvee

Thormann

2001

Electrophoresis

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Therapeutic drug monitoring of carbamazepine (CBZ), a widely used antiepileptic drug, is required for optimization of pharmacotherapy with this drug and for assessment of the patient's compliance to therapy. The suitability of employing micellar electrokinetic capillary chromatography (MEKC) in the absence of electroosmosis for the determination of CBZ and its main metabolite carbamazepine-10,11-epoxide (CBZE) in extracts of human serum and plasma is reported. Using micelles formed by dodecyl sulfate, analyses performed in untreated fused-silica capillaries at acidic pH and in commercially available coated capillaries under application of reversed polarity are compared. Uncoated and polyvinyl alcohol coated capillaries proved to be unsuitable for this purpose, whereas capillaries coated with linear polyacrylamide and N-acryloylaminoethoxyethanol and operated at pH 7.6 are shown to provide high-quality and reliable data on a short time scale. Assay performance is discussed via statistical analysis of the data produced from a set of quality control sera that contain up to 14 different drugs and via analysis of patient samples. Intraday and interday imprecision data for concentrations between 4.0 and 84 microM are demonstrated to be < 10%. Run times are shown to be < 50% compared to those observed in conventional MEKC at alkaline pH (i.e., in the presence of electroosmosis).

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“…Ñóùåñòâóåò ðÿä õðîìàòîãðàôè÷åñêèõ ìåòîäèê [11,12], ïîçâîëÿþùèõ îïðåäåëÿòü â ñûâîðîòêå êðîâè ïàöèåíòîâ êàê êîíöåíòðàöèþ ñàìîãî I, òàê è êîíöåíòðàöèè I è II ïðè ñîâìåñòíîì ïðèñóòñòâèè [13 -18]. Íåñìîòðÿ íà âûñîêóþ ÷óâñòâèòåëüíîñòü è øèðîêèé àíàëèòè÷åñêèé äèàïàçîí, ñóùåñòâåííûì íåäîñòàòêîì äàííûõ ìåòîäèê ÿâëÿåòñÿ äëèòåëüíîå âðåìÿ ïðîáîïîäãîòîâêè è ïðîâåäåíèÿ àíàëèçà.…”

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Экспресс-Методика Определения Карбамазепина И Карбамазепин-10,11-Эпоксида Методом Вэжх-Мс/Мс

Родина¹,

Мельников²,

Sokolov³

et al. 2016

Хим.-фарм. ж.

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Разработана экспресс-методика одновременного определения карбамазепина и карбамазепин-10,11-эпоксида в сыворотке крови человека с использованием метода ВЭЖХ с тандемным масс-спектрометрическим детектированием. Аналитический диапазон для карбамазепина составил 50 – 20000 нг/мл и для карбамазепин-10,11-эпоксида 5 – 2000 нг/мл, что позволяет использовать настоящую методику как для осуществления терапевтического лекарственного мониторинга, так и для проведения исследований биоэквивалентности и оценки взаимозаменяемости препаратов карбамазепина.

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Simple and rapid gas—liquid chromatographic method for estimating carbamazepine in serum

Cited by 7 publications

References 9 publications

Quantitative bioanalytical and analytical method development of dibenzazepine derivative, carbamazepine: A review

Quantitative bioanalytical and analytical method development of dibenzazepine derivative, carbamazepine: A review

Determination of carbamazepine and carbamazepine-10,11-epoxide in human serum and plasma by micellar electrokinetic capillary chromatography in the absence of electroosmosis

Экспресс-Методика Определения Карбамазепина И Карбамазепин-10,11-Эпоксида Методом Вэжх-Мс/Мс

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