Simple and reliable high-performance liquid chromatography fluorimetric procedure for the determination of amphetamine-derived designer drugs

Ecstasy (MDMA) and oral health

“…Determining ecstasy in saliva with the Drugwipe® agrees well with the determination of ecstasy with gas chromatography -mass spectrometry, the most widely used method to confi rm positive results. 43 Liquid chromatography -mass spectrometry is rarely applied for the detection of ecstasy in saliva. 44 Unfortunately, the use of saliva for determination of ecstasy also has taining disadvantages.…”

Fast LC–MS/MS method for the determination of amphetamine, methamphetamine, MDA, MDMA, MDEA, MBDB and PMA in urine

“…For plasma different LC-MS methods for the determination of amphetamines and designer drugs have been published [24,27,[29][30][31][32]. Despite these modern techniques, traditionally the most widely used technique for the determination of designer drugs by high performance liquid chromatography (HPLC), was HPLC with fluorescence detection [33][34][35][36][37][38][39][40].…”

An electrospray ionisation tandem mass spectrometric investigation of selected psychoactive pharmaceuticals and its application in drug and metabolite profiling by liquid chromatography/electrospray ionisation tandem mass spectrometry

“…In addition, only a small number of individual drugs have been targeted in these studies 14–18. With the drug concentration in oral fluid reflecting the unbound and pharmacologically active drug concentration,19–21 saliva has been used for the detection of amphetamines, opiates, cocaine and its major metabolite, benzodiazepines and various other hypnotics using GC/MS and LC with fluorescence detection 22–24. LC/ESI‐MS has rarely been used for the detection of antidepressants and antipsychotics in oral fluids and the compounds that have been detected in this matrix have included amphetamines and related designer drugs, cocaine, opiates, methadone, various hypnotics and nicotine 25–30…”