Simple and sensitive spectrophotometric methods for determination of amantadine hydrochloride

Darwish, Ibrahim A.; Khedr, Alaa; Askal, Hassan F.; Taha, Rania H.

doi:10.1007/s10812-006-0157-2

Cited by 22 publications

(18 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Oxidation-reduction reactions have been used as the basis for the development of simple and sensitive spectrophotometric methods for the determination of many pharmaceutical compounds [95][96][97][98][99] . Cerric (IV) ammonium sulphate, because of its high oxidation potential and excellent solution stability, has been widely used as an effective analytical reagent in these methods 95 .…”

Section: Resultsmentioning

confidence: 99%

Cerimetric Determination of Four Antihypertensive Drugs in Pharmaceutical Preparations

El‐Didamony

Erfan

2011

J. Chil. Chem. Soc.

View full text Add to dashboard Cite

A sensitive spectrophotometric method is described for the determination of atenolol (ATE), timolol maleate (TIM), captopril (CPL) and diltiazem hydrochloride (DIL.HCl) in bulk drugs and in pharmaceutical preparations. The method is based on the oxidation of the studied drugs by a known excess of cerric (IV) in acid medium followed by determination of unreacted oxidant by adding a fixed amount of methyl orange dye (MO) and the increasing in absorbance is measured at 510 nm. In this method the amount of cerium (IV) reacted corresponds to drugs concentration. The experimental conditions were optimized. Regression analysis of a Beer's plot showed good correlation in the concentration ranges of 3.2-6.4, 8.0-18, 3.4-5.2 and 3.6-5.2 µg/ml for ATE, TIM, CPL and DIL.HCl, respectively. The calculated molar absorptivity values are 5.28×10 4 , 3.27×10 4 , 6.43×10 4 and 1.12×10 5 L /mol cm, respectively and the corresponding Sandell's sensitivity values are 5.043, 13.2, 3.381 and 4.024 ng/cm 2 , respectively. The limit of detection (LOD) and quantification (LOQ) are reported. No interference was observed from the additives and the applicability of the method was tested by analyzing the pharmaceutical preparations containing the investigated drugs. Statistical comparison of the results with those of official methods shows excellent agreement and indicates no significant difference in precision.

show abstract

Section: Resultsmentioning

confidence: 99%

Cerimetric Determination of Four Antihypertensive Drugs in Pharmaceutical Preparations

El‐Didamony

Erfan

2011

J. Chil. Chem. Soc.

View full text Add to dashboard Cite

show abstract

“…24 The relative lower zeta potential may increase the colloidal stability and the circulation period in the body. [23][24][25] In particular, the reduced uptake of anionic particles by the reticular endothelial system (RES) in the liver and spleen or immune cells (such as macrophages) can result in a prolonged circulation time. [23][24][25] Figure 4 indicates that there was no difference between the average particle sizes with time for both samples.…”

Section: Resultsmentioning

confidence: 99%

“…AMT (10 mg) and polymer (50 mg) dissolved in DMSO (5 mL) were dialyzed against a HCl (or NaOH)-Na 2 B 4 O 7 buffer solution (pH 7.4, 10 mM) for 24 h to fabricate the drug-loaded polymeric micelles. The AMT concentration in micelles was determined by measuring the UV absorbance at 682 nm (for AMT) 23 of drug-loaded polymeric micelles dissolved in a DMSO/buffer mixture solution (95 : 5 vol%) using a UV/visible spectrophotometer. AMT loading efficiency was 71±4 or 81±5 wt%, respectively, as calculated by dividing the loading drug content by the feeding drug content.…”

Section: Introductionmentioning

confidence: 99%

Preparation of multifunctional polymeric micelles for antiviral treatment

et al. 2010

View full text Add to dashboard Cite

In this study, a poly(L-lactic acid)-b-poly(ethylene glycol) (PLLA-b-PEG) diblock copolymer modified with a sialic acid derivative (methyl-b-neuraminic acid: mNA) was prepared for the development and application of a therapeutic nanosystem with multifunctionality. The terminal carboxyl group of PEG was coupled with mNA via N,N'-dicyclohexyl carbodiimide (DCC)-and N-hydroxysuccinimide (NHS)-mediated amide formation. Polymeric micelles were formed using the diafilteration method at pH 7.4, which resulted in a micelle self-assembly with the PLLA block at the core and PEG-mNA block on the shell. An anionic charge was formed on the surface of the micelle at physiological pH (~pH 7.4) due to mNA. Amantadine (AMT), a model drug for antiviral treatment, was loaded into the micellar core. These micelles were expected to exhibit multiple therapeutic activity that originated from the antiviral activity of mNA on the shell and the sustained release of AMT from the micellar core.

show abstract

“…The absorption located at 259/253 nm was the CT band between iodine and AMD/AMDHCl and increased with increasing concentration of AMD/ AMD-HCl, which can be used to detect AMD/AMD-HCl. The reason why absorption peaks of I3 -are not suitable for determination is these two peaks appear commonly in many interaction systems reported [9][10][11] and are not selective. Even when the adamantane (without amine group interacting with iodine) was added, these two peaks still existed (Fig.…”

Section: Selection Of Suitable Halogen Bond Donors and Solvents For Amentioning

confidence: 99%

“…Methods for detecting the compounds with an amine group by complexation with iodine have been reported, but all of them used I3 -absorption bands (290 and 365 nm) as detection peaks. [9][10][11] Actually, I3…”

Section: Introductionmentioning

confidence: 99%

The Halogen Bond between Amantadine and Iodine and Its Application in the Determination of Amantadine Hydrochloride in Pharmaceuticals

et al. 2014

View full text Add to dashboard Cite

It is proposed that molecular iodine as a donor could form halogen bonding complexes with amantadine (AMD) and amantadine hydrochloride (AMD-HCl) in chloroform and the resultant charge transfer bands (CT band) would be located at 259 and 253 nm, respectively. The halogen bonding interaction was explored by UV absorption, Raman and X-ray crystallography, and a new bonding model named N + ···N lep bond in crystal was observed. The halogen bonding complexes were utilized in the development of simple and accurate spectrophotometry for the analysis of AMD/AMD-HCl. Compared with the traditional method based on the absorption of I3 -at 290 and 365 nm, the new proposed spectrometry based on the CT band of halogen bonding complex was more sensitive and selective for the detection of AMD/AMD-HCl. Linear relationships with good correlation coefficients (>0.9994) were obtained between the absorbance and the AMD/AMD-HCl concentration in the range of 10 -180 μg mL -1 for AMD-HCl and 0.2 -13 μg mL -1 for AMD. The limit of detection (LOD) was 2.23 μg mL -1 and limit of quantification (LOQ) was 7.45 μg mL -1 for AMD-HCl. And because of the stronger bond constant between AMD and iodine than AMD-HCl, the method is more sensitive for AMD; the LOD was 0.02 μg mL -1 and LOQ was 0.08 μg mL -1 which was 100 times lower than that of AMD-HCl. Keywords

show abstract

Simple and sensitive spectrophotometric methods for determination of amantadine hydrochloride

Cited by 22 publications

References 23 publications

Cerimetric Determination of Four Antihypertensive Drugs in Pharmaceutical Preparations

Cerimetric Determination of Four Antihypertensive Drugs in Pharmaceutical Preparations

Preparation of multifunctional polymeric micelles for antiviral treatment

The Halogen Bond between Amantadine and Iodine and Its Application in the Determination of Amantadine Hydrochloride in Pharmaceuticals

Contact Info

Product

Resources

About