Simple Capsule for Multiple Intestinal Biopsy Specimens

Choudhury, Dhiraj; Nicholson, G; Cooke, W. T.

doi:10.1016/s0140-6736(64)90238-7

Cited by 37 publications

(12 citation statements)

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“…Mucosal changes were classified according to RoyChoudhury et al [14] as follows: normal (grade 0), mildly abnormal (grade I), partial villous atrophy (grade II) and subtotal villous atrophy (grade III).…”

Section: Methodsmentioning

confidence: 99%

Antibodies to Gliadin in Adult Coeliac Disease and Dermatitis herpetiformis

et al. 1984

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Antibodies to gliadin, searched for by indirect immunofluorescence and a micro-ELISA, were detected in 16 (64%) of 25 sera from patients with adult coeliac disease and in 13 (45%) of 29 with dermatitis herpetiformis. Although the sensitivity of the two tests was relatively low in the whole groups, it increased when only cases with severe jejunum abnormalities were considered (93% for coeliac disease and 81% for dermatitis herpetiformis). A significant correlation was found between antigliadin antibodies and the severity of jejunum damage in both diseases. Moreover, most coeliac and dermatitis herpertiformis patients with antigliadin antibodies were on normal diet. The specificity of the tests was 100% for the immunofluorescence and fairly good for the micro-ELISA, as only 5(11 %) of the 46 disease control patients (Crohn’s disease, ulcerative colitis) were positive for antigliadin antibodies. R1 -reticulin antibody test was equally specific but less sensitive in both groups. We conclude that antigliadin antibodies are useful in the diagnosis of patients with active adult coeliac disease and dermatitis herpetiformis with gluten-sensitive enteropathy. Moreover, the two tests make it possible to monitor the compliance to gluten-free diet in both diseases.

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Section: Methodsmentioning

confidence: 99%

Antibodies to Gliadin in Adult Coeliac Disease and Dermatitis herpetiformis

et al. 1984

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“…Also examined were jejunal biopsies from 15 other coeliac patients on a normal diet, 15 coeliac patients who had been on a strict gluten-free diet for more than one year, and 15 healthy controls. In six of the 18 patients with 458 lymphoma, jejunal biopsies were obtained at a postmortem examination performed within one hour of death; in all other individuals peroral jejunal biopsies were obtained using the Roy-Choudhury capsule (Choudhury, Nicholson, and Cooke, 1964).…”

Section: Methodsmentioning

confidence: 99%

The jejunal cellular infiltrate in coeliac disease complicated by lymphoma

Ferguson¹,

Asquith²,

Cooke³

1974

Gut

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Results showed that although the lymphoma patients have abnormal counts compared with controls, they differed from untreated coeliacs in that they had lower plasma cell and higher lymphocyte counts in the lamina propria and lower lymphocyte counts in the epithelium. Such changes tended to be present for up to five years before the diagnosis of lymphoma was made. The results suggest that the immunological status of coeliac patients with lymphoma differs from that of other coeliacs and it could represent a primary abnormality and also be relevant to the development of lymphoma.

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“…The barium meal examination revealed no evidence of gastroduodenal ulceration in any patients. Peroral gastric mucosal biopsy was obtained by the capsule designed by Roy-Chowdhury et al (32), processed and stained with hematoxylin and eosin. The criteria of Bock et al (2) for morphological changes in the gastric mucosa were followed.…”

Section: Methodsmentioning

confidence: 99%

Gastric Acid Secretory Responses to Graded Intravenous Doses of Histamine in Hookworm Anemia

Bajaj

Chuttani

et al. 1976

Digestion

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Dose-response curves for the effect of continuous infusion of histamine on gastric acid secretion were obtained in 10 patients with iron deficiency anemia due to hookworm infection. Each patient was studied with 4 doses (40, 60, 80 and 100 μg/kg/h) of histamine acid phosphate administered for 3 h, on separate days, in random fashion. The acid output increased with the dose of histamine, the maximal acid output was reached in all patients at the dose of 100 μg/kg/h. The dose of histamine when calculated according to body weight correlated well with the maximal acid output; the absolute dose of histamine had no correlation with the maximal acid response. The dose-response curve of stimulated acid output in anemia patients was much flatter than in control patients.

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Simple Capsule for Multiple Intestinal Biopsy Specimens

Cited by 37 publications

References 0 publications

Antibodies to Gliadin in Adult Coeliac Disease and Dermatitis herpetiformis

Antibodies to Gliadin in Adult Coeliac Disease and Dermatitis herpetiformis

The jejunal cellular infiltrate in coeliac disease complicated by lymphoma

Gastric Acid Secretory Responses to Graded Intravenous Doses of Histamine in Hookworm Anemia

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