Simple Determination of Bosentan in Plasma Samples by Reversed-Phase High-Performance Liquid Chromatography
Zahra Khalighi,
Hori Ghaneialvar,
Armin Soltani
et al.
Abstract:Background: In order to measure the plasma levels of Losartan and Bosentan, a sensitive Reverse Phase-High Performance Liquid Chromatography (RP-HPLC) technique was developed.
Methods: To compare bioavailability, the Area Under the Curve (AUC), peak plasma concentration (Cmax), and time to Cmax (Tmax) were employed. The standard curve (150-2400 ng/ml) was linear (R2=0.999), relative errors were between 2.4 to 10.05% and the coefficient of variation (CV%) ranged from 1.52 to 10.88. A single dosage (test a… Show more
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