Simple enumerations of peripheral blood natural killer (CD56+ NK) cells, B cells and T cells have no predictive value in IVF treatment outcome

Thum, Meen‐Yau; Bhaskaran, Shree; Bansal, Amolak S.; Shehata, Hassan; Ford, Brian; Sumar, N.; Abdalla, Hossam

doi:10.1093/humrep/deh774

Cited by 60 publications

(39 citation statements)

References 20 publications

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“…B lymphocytes express c-Myc proto-oncogene which can stimulate angiogenesis via production of VEGF [34]. However, there does not seem to be a significant difference between the number of endometrial B cells [35] or peripheral B cells [36] in women with normal obstetrical histories compared to those with a history of recurrent miscarriage undergoing IVF treatments.…”

Section: B and T Lymphocytesmentioning

confidence: 99%

Angiogenesis in implantation

Torry

Leavenworth

Chang

et al. 2007

J Assist Reprod Genet

149

109

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Section: B and T Lymphocytesmentioning

confidence: 99%

Angiogenesis in implantation

Torry

Leavenworth

Chang

et al. 2007

J Assist Reprod Genet

149

109

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show abstract

“…It has been found that in women with a history of RM, 37.3 % had a mild to moderate increase (12–18 %) and 14.7 % a marked increase (>18 %) in peripheral blood CD56 + NK cells. An NK cell percentage of <12 % is strongly associated with a subsequent successful pregnancy [20, 26]. However, these findings have not been confirmed by other studies that concluded that peripheral NK cell numbers do not necessarily correlate with NK cell cytotoxicity, which can be represented by markers such as KIRs (killer inhibitory receptors) or CD16 receptor expression [27].…”

Section: Introductionmentioning

confidence: 99%

Combined oral prednisolone and heparin versus heparin: the effect on peripheral NK cells and clinical outcome in patients with unexplained recurrent miscarriage. A double-blind placebo randomized controlled trial

Gomaa

Elkholy

El-Said

et al. 2014

Arch Gynecol Obstet

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PurposeTo evaluate the efficacy of the use of oral Prednisolone and heparin versus the use of heparin alone in treatment of patients with unexplained recurrent miscarriage.MethodologyThe study was a double-blind placebo randomized control trial conducted on 160 patients with unexplained recurrent miscarriage. Patients recruited were randomized into two groups. The first group received oral Prednisolone in addition to low dose aspirin and heparin, while the other group received a placebo in addition to low dose aspirin and heparin. A peripheral venous blood sample was taken from all included patients before starting treatment and collected in heparinized tubes. Natural Killer (NK) cells were checked in each sample and then re-checked in another sample at 20 weeks of gestation.ResultsWe found that in the prednisolone group, 70.3 % of women had successful outcome (defined as an ongoing pregnancy beyond 20 weeks gestation), while 29.7 % miscarried before this gestation. On the contrary, among women in the placebo group, 9.2 % had successful outcome while 90.8 % miscarried before 20 weeks, which was statistically significant. On the other hand, we found that there were no significant paired differences between initial serum levels of the NK cells markers CD16 and CD56 and their levels at 20 weeks gestation in both groups.ConclusionThe addition of prednisolone to heparin and low dose aspirin might be beneficial in patients with unexplained recurrent miscarriage, and this effect might be due to a suppressive effect of steroids on the peripheral CD16 NK cells concentration.

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“…Studies have also revealed a close correlation between an increased number of uterine NK cells (uNK) in the mid‐secretory phase and the occurrence of unexplained RM . The relationship between NK cells and pregnancy outcome as well as the associated mechanisms remains the subject of intense debate.…”

Section: Introductionmentioning

confidence: 99%

Effect of Prednisolone Administration on Patients with Unexplained Recurrent Miscarriage and in Routine Intracytoplasmic Sperm Injection: A Meta‐Analysis

Song

Wang

Shi

et al. 2015

American J Rep Immunol

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The effects of prednisolone on pregnancy outcome are open to debate. This meta-analysis was performed to evaluate the efficiency of prednisolone administration on unexplained recurrent miscarriage (RM) and the process of assisted reproductive technology (ART). Relevant publications were searched from databases and the included randomized controlled trials (RCTs) investigated effects of prednisolone administration in women with unexplained RM or during ART. The outcomes in our analysis were measured in terms of risk ratios (RRs) with 95% confidence intervals (CI) using random effect models. This meta-analysis was performed based on pregnancy outcomes following prednisolone treatment. This meta-analysis provides evidence that prednisolone therapy improves pregnancy outcomes in women with idiopathic RM (live birth rate: RR 1.58, 95% CI 1.23-2.02; successful pregnancy outcome: RR 7.63, 95% CI 3.71-15.69; miscarriage rate: RR 0.42, 95% CI 0.28-0.61). Our meta-analysis revealed a non-significant effect of prednisolone on pregnancy outcome during intracytoplasmic sperm injection (ICSI) cycles (pregnancy rate: RR 1.02, 95% CI 0.84-1.24; clinical pregnancy rate: RR 1.01, 95% CI 0.82-1.24; implantation rate: RR 1.04, 95% CI 0.85-1.28). Prednisolone administration may improve pregnancy outcomes in women with idiopathic RM; its efficacy in women undergoing ICSI is not significant.

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Simple enumerations of peripheral blood natural killer (CD56+ NK) cells, B cells and T cells have no predictive value in IVF treatment outcome

Cited by 60 publications

References 20 publications

Angiogenesis in implantation

Angiogenesis in implantation

Combined oral prednisolone and heparin versus heparin: the effect on peripheral NK cells and clinical outcome in patients with unexplained recurrent miscarriage. A double-blind placebo randomized controlled trial

Effect of Prednisolone Administration on Patients with Unexplained Recurrent Miscarriage and in Routine Intracytoplasmic Sperm Injection: A Meta‐Analysis

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