The reference evapotranspiration (ETo) is a complex measure essential to water resources planning and management, irrigation scheduling, and rational agricultural water use. This research aimed to evaluate the performance of the empirical methods in estimating reference evapotranspiration based on daily meteorological data of the surface and comparing them with the standard method of Penman-Monteith (PM-FAO 56), during the period of January/2004 to December/2013 for the climatic conditions of the semiarid region of Brazil. Five empirical methods were evaluated: Hargreaves -Samani (HS), Camargo (C), Thornthwaite (Th), Priestley-Taylor (PT), and Jensen-Haise (JH). For this purpose, maximum air temperature (Tmax, ºC) and minimum (Tmin, ºC); maximum air relative humidity (RHmax, %) and minimum (RHmin, %); maximum air atmospheric pressure (Pmax, kPa) and minimum (Pmin, kPa); average wind speed at a height of 2 meters (u2m, m s -1 ); global solar radiation (MJ m -2 ); and precipitation (mm) were used at this study. Analysis data were executed using descriptive statistics, correlation, dispersion, and statistical accuracy indexes to compare empirical models with the PM -FAO 56. The JH method overestimated the standard Penman-Monteith method, and underestimated by the HS, C, Th, and PT methods, on a monthly average scale. In general, HS and JH methods had bett er adjustments with PM-FAO 56, on a daily scale. In conclusion, empirical methods, on a daily scale, presented good correlations and satisfactory statistical indices, being important in agricultural planning and irrigation management, becoming a good alternative for semiarid conditions of Petrolina -PE in San Francisco mesoregion.