The standard state-dependent Heisenberg-Robertson uncertainly-relation lower bound fails to capture the quintessential incompatibility of observables as the bound can be zero for some states. To remedy this problem, we establish a class of tight (i.e., inequalities are saturated) variance-based sum-uncertainty relations derived from the Lie algebraic properties of observables and show that our lower bounds depend only on the irreducible representation assumed carried by the Hilbert space of state of the system. We illustrate our result for the cases of the Weyl-Heisenberg algebra, special unitary algebras up to rank 4, and any semisimple compact algebra. We also prove the usefulness of our results by extending a known variance-based entanglement detection criterion.For ∆w 2 signifying the variance of measurement outcomes for the observable w, Heisenberg's uncertainty relation for position x and momentum p iswhere [x, p] = i1, and 1 is the identity operator. Eq. (1) fortuitously has a constant lower bound due to the appealing algebraic properties of the commutator of x and p. Robertson's generalization to ∆A 2 ∆B 2 ≥ | [A, B] | 2 /4 for arbitrary observables A and B more generally has a state-dependent lower bound [1], and so fails to capture the intrinsic incompatibility of noncommuting observables [2,3]. This cannot be amended as the underlying product of uncertainties is null whenever one of the uncertainties is null, an observation that provided impetus for the emergence of uncertainty relations [4-9] that eschew variance in favor of entropy. Properly assessing uncertainty is important for foundational quantum mechanics [10][11][12] and for quantum information and communication [13][14][15][16]; variance is closer than entropy for practical quantum mechanics, a driving motivation behind research into sum-uncertainty relations (SURs), which deliver state-independent lower bounds [17][18][19][20][21][22][23][24][25]. Here we discuss SURs by showing connections with the algebras of observables, with examples of the Weyl-Heisenberg wh, special unitary su(n) and su(1, 1) and generally semi-simple compact algebras thereby extending the range to applications of SURs in areas such as [26,27] and quantum information [28] where u(n) or su(n) symmetries are prevalent.Indeed, single-photon multi-path quantum optical interferometry provides a convenient way to realize SU (n) symmetry [29][30][31][32] with the experimental signature obtained via sampling photodetection of the photon emerging from each of the n output ports, both by direct detection and by adding special post-processing interferometers at the output followed by photodetection. Photodetection sampling statistics obtained in these ways yield uncertainties from estimates second-order cumulants for the distributions and, through this process, our uncer-(a) (b) FIG. 1: Sum of variances is a measure of total uncertainty. Given a (green) box with the uncertainties as edges, the sum of variances is the squared length of the (red) diagonal. [Here 30000 (blue) points ...