Simple indole alkaloids and those with a nonrearranged monoterpenoid unit

Abstract

This review covers the literature on simple indole alkaloids and those with a nonrearranged monoterpenoid unit. Newly isolated alkaloids, structure determinations, total syntheses and biological activities are included.

Molecular Iodine‐Mediated Cascade Reaction of 2‐Alkynylbenzaldehyde and Indole: An Easy Access to Tetracyclic Indoloazulene Derivatives

“…+ , 607 (95) 1,143.3,138.9,138.8,138.3,135.2,132.7,129.8,128.5,128.3,127.5,127.4,126.2,126.0,125.8,125.8,125.3,125.1,124.4,124.1,123.4,121.2,120.8,120.7,114.6,113.1,112.9,107.5,101.5,100.1,37.8;: m/z (relative intensity) = 598 (100) [M] + ; HR-MS: m/z = 598.0654, calcd. for C 35 H 19 IN 4 [M] + : 598.0650.…”

“…[1] Particularly, the seven-membered ring (azulene) annulated tetracyclic indole moiety occurs in numerous biologically active natural products and pharmaceutical intermediates, which display potent antihistaminic, antimicrobial and anticancer activities. [1,2] In general, the construction of medium sized rings is unambiguously considered to be a cumbersome task due to a combination of the transannular interactions and unfavourable entropic and enthalpic factors.…”

 

“…They are committed to synthesizing bisindole derivatives, testing drug properties, and separating new molecules. [3,4] In this review, we discussed the bioactivities and biosynthetic pathways of bisindole compounds.…”

“…Many indole molecules have been isolated from natural substances, and most of them own significant medicinal properties. [2] A hundreds of bisindole molecules [3] were separated and characterized, but their biosynthetic mechanisms have been largely unexplored. This bisindole compounds have been isolated from the shawls, sponges, plant leaves, roots, bark, flowers, algae, fungi and mycotic fungi, [3] most commonly isolated from actinomycetes, [3] a class of bacteria known for production of secondary metabolites.…”

“…[2] A hundreds of bisindole molecules [3] were separated and characterized, but their biosynthetic mechanisms have been largely unexplored. This bisindole compounds have been isolated from the shawls, sponges, plant leaves, roots, bark, flowers, algae, fungi and mycotic fungi, [3] most commonly isolated from actinomycetes, [3] a class of bacteria known for production of secondary metabolites. [4] In recent years, most scientists are interested in the use of bisindoles as drug molecules.…”