Abstract-In this letter, we address the theoretical limitations in estimating the mixing matrix in noisy sparse component analysis (SCA) for the two-sensor case. We obtain the Cramér-Rao lower bound (CRLB) error estimation of the mixing matrix. Using the Bernouli-Gaussian (BG) sparse distribution, and some simple assumptions, an approximation of the Fisher information matrix (FIM) is calculated. Moreover, this CRLB is compared to some of the main methods of mixing matrix estimation in the literature.Index Terms-Blind source separation, Cramér-Rao bound, mixing matrix estimation, sparse component analysis.