Simple non-invasive markers for early diagnosis and determination of the severity of liver diseases

Abstract

Aim of the studyThe aim of the study was to evaluate the effect and severity of liver diseases of different etiologies on the values of three non-invasive fibrosis markers.Material and methodsSerum samples from 65 patients with alcoholic cirrhosis, 31 with non-alcoholic cirrhosis and 32 with toxic hepatitis, were tested. Cirrhotic patients were classified according to the Child-Pugh scale. The age-platelet (AP) index, HUI score and Fibro Q index were calculated using the specific formulas.ResultsThe values of all tested scores were significantly higher in controls than in patients with liver diseases and were significantly different between liver diseases. The patients with alcoholic and non-alcoholic cirrhosis had higher values of the AP index, HUI score and Fibro Q index than patients with toxic hepatitis. HUI and Fibro Q scores appeared to vary according to the severity of liver damage and were higher in Child-Pugh class C than in classes A and B.ConclusionsWe conclude that all tested scores based on liver function tests are good markers for non-invasive diagnosis of liver damage. Additionally, HUI and Fibro Q scores reflect the severity of liver cirrhosis.

HDV: Epidemiology, lifecycle, testing, and treatment

“…These markers include aspartate aminotransferase to alanine transaminase ratio, ageplatelet index, aspartate aminotransferase-platelet ratio index, fibrosis-4 index and the Hui score (includes body mass index, bilirubin, albumin, and platelet count). [7] FIB-4 was the top performer in HCV, HBV, and HDV viral infections. But when studied in patients with HDV it did not significantly outperform the other tests.…”

“…Noninvasive markers of fibrosis, outlined in Figure 3, were developed and validated for HCV and then further validation with HBV virus but further validation in HDV is still needed. These markers include aspartate aminotransferase to alanine transaminase ratio, age-platelet index, aspartate aminotransferase-platelet ratio index, fibrosis-4 index and the Hui score (includes body mass index, bilirubin, albumin, and platelet count) 7 . FIB-4 was the top performer in HCV, HBV, and HDV viral infections.…”

FIB-4 and APRI scores for predicting severe liver fibrosis in chronic hepatitis HCV patients: a monocentric retrospective study

“…Invasive approach es include liver biopsy. However, this is very expensive and it is not routinely performed in all centers [8,9]. Therefore, over the years, various imaging methods and biomarkers have been tested for the diagnosis of liver fibrosis [10,11].…”