2017
DOI: 10.1021/acs.iecr.7b03395
|View full text |Cite
|
Sign up to set email alerts
|

Simple Observer-Based Feedback Strategy for Controlling Fed-Batch Hybridoma Cultures

Abstract: Cultures of hybridoma cells in bioreactors are commonly used to produce monoclonal antibodies. As an alternative to nonlinear model predictive control, which has recently been applied successfully to optimize the process productivity, a simpler control approach is developed in the present study. This strategy is based on a classical PI controller and software sensors for the reaction rates, which exploit the particular structure of the dynamic model. The dynamic behavior of the process can indeed be subdivided… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Year Published

2019
2019
2022
2022

Publication Types

Select...
2

Relationship

0
2

Authors

Journals

citations
Cited by 2 publications
references
References 13 publications
0
0
0
Order By: Relevance