FALLING is a major health concern among elderly people because it increases the incidence of fractures and causes a deterioration in mobility. It is reported that one in three people over 65 years of age fall at least once per year and that half of elderly people over 80 years of age experience at least one fall per year [1][2][3]. Moreover, the severity of fall-related complications increases with aging. Fractures are one of the most serious fall-related injuries and can lead to a loss of independence through disability and fear of falling. The reduction in mobility and independence is a serious issue in aging societies because it often results in admission to a hospital or nursing home and can potentially result in premature death. Additionally, diabetes mellitus (DM) is known to be associated with an Department of Medicine, Diabetes, Metabolism and Endocrinology, Matsuyama Red Cross Hospital, Japan Abstract. Diabetes mellitus is associated with an increased risk of falls, which increases the incidence of osteoporotic fractures and accordingly decreases quality of life. However, the association between fall risk and diabetic complications is not completely understood. Therefore, the aim of this study was to examine the association between fall risk and osteoporotic fractures in patients with type 2 diabetes mellitus (T2DM). We enrolled 194 Japanese patients with T2DM and assessed their fall risk using a brief interview form that included five items covering physical and social aspects of functioning and environmental factors. We examined the associations between fall risk and the presence of diabetic complications, such as neuropathy, retinopathy, nephropathy, cardiovascular disease, cerebrovascular disease, peripheral artery disease (PAD), and osteoporotic fractures (including any fracture and vertebral fractures only). In the multivariate logistic regression analysis, a longer history of T2DM, the presence of neuropathy and PAD, and a history of any fractures were significantly and positively associated with the risk of falls. On the other hand, a lower body mass index, the presence of neuropathy, and the risk of falls were independently and positively associated with the risk of any fracture. When fractures were limited to vertebral fractures only, the association with the risk of falls remained significant. We found that the risk of falls and osteoporotic fractures were associated in patients with T2DM and that a brief screening test of the risk of falls was useful for assessing the risk of osteoporotic fractures.Key words: Fall, Osteoporosis, Fracture, Neuropathy, Type 2 diabetes mellitus increased risk of falling [4][5][6]. Therefore, it is no less important to assess the risk of falls in diabetic patients than it is in their non-diabetic counterparts. Osteoporosis has been recognized as one of the complications of DM. Accumulating evidence shows that patients with DM have an increased risk of osteoporotic fractures independently of their bone mineral density (BMD) [7][8][9]. Several meta-analyses ha...