Simple spike dynamics of Purkinje cells in the macaque vestibulo-cerebellum during passive whole-body self-motion

Laurens, Jean; Angelaki, Dora E.

doi:10.1073/pnas.1915873117

Cited by 15 publications

(27 citation statements)

References 85 publications

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“…PCD mainly involves the vermis and midline structures of the cerebellum in the early stage, and under physiological conditions, the midline structure of the cerebellum mainly participates in the integration of otolith and semicircular canal signals[ 15 ], controls the otolith-ocular reflex, and participates in the regulation of the semicircular canal-ocular reflex. When the midline structure of the cerebellum is dysfunctional, the integration of otolith and semicircular canal signals becomes dysfunctional.…”

Section: Discussionmentioning

confidence: 99%

Anti-Yo antibody-positive paraneoplastic cerebellar degeneration in a patient with possible cholangiocarcinoma: A case report and review of the literature

Lou

Zhang

et al. 2021

WJCC

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BACKGROUND Paraneoplastic cerebellar degeneration (PCD), which is rare in clinical practice, is closely related to autoimmunity. Cases positive for anti-Yo antibodies (anti-Purkinje cytoplasmic antibody 1) are the main subtype of PCD. PCD is subacute cerebellar degeneration, and while it progresses over weeks to months, its resultant deficits last much longer. Cancer patients with anti-Yo antibody-positive PCD are very rare. Most of them are breast cancer or ovarian cancer patients but also occasionally lung cancer patients. CASE SUMMARY A 61-year-old woman presented with sudden vertigo, nausea, and vomiting for approximately 10 d. The patient's neurological examination showed torsion with downbeat nystagmus and ataxia of the right limb and trunk. Laboratory examination found that the patient's cerebrospinal fluid and serum were anti-Yo antibody-positive, positron emission tomography computed tomography showed an increased metabolic rate in the retroperitoneal lymph nodes, and the pathology of lymph node punctures in the retroperitoneum and neck suggested adenocarcinoma of the pancreaticobiliary duct, which strengthens the hypothesis of paraneoplastic origin. Intravenous immunoglobulin (IVIg) 0.4 g/kg/d for 5 d and methylprednisolone 160 mg for 3 d were initiated, which was reduced to 80 mg for 3 d and then to 40 mg for 7 d. After treatment with IVIg and a steroid, the patient's vertigo and ataxia alleviated. CONCLUSION The patient's vertigo and ataxia alleviated after treatment, suggesting that early immunotherapeutic intervention may have certain value in stopping neurological loss.

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Section: Discussionmentioning

confidence: 99%

Anti-Yo antibody-positive paraneoplastic cerebellar degeneration in a patient with possible cholangiocarcinoma: A case report and review of the literature

Lou

Zhang

et al. 2021

WJCC

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“…1B-D ) (Borah et al, 1988; Bos & Bles, 2002; Glasauer & Merfeld, 1997; Karmali & Merfeld, 2012; Laurens & Angelaki, 2011, 2017; Laurens & Droulez, 2007; Merfeld, 1995; Oman, 1982; Ormsby & Young, 1977; Zupan et al, 2002). A unique advantage of this system is the ability to map complex, but well-understood, algorithmic computations implementing an internal model of the inner ear’s inertial motion sensors, the otolith organs, into a cerebellar circuit that includes lobules X and IX of the cerebellar vermis (Nodulus and Uvula; NU) (Laurens et al, 2013a, 2013b; Laurens & Angelaki, 2020; Stay et al, 2019; Yakusheva et al, 2007, 2008, 2013).…”

Section: Introductionmentioning

confidence: 99%

“…First, translation-selective cells ( Fig. 1D s) encode otolith predictions error (Laurens et al, 2013a, 2013b; Laurens & Angelaki, 2020; Stay et al, 2019; Yakusheva et al, 2007, 2008, 2013). These cells respond selectively to passive translation, indicating that they (i) receive otolithic inputs, (ii) are cancelled by tilt signals originating from rotation sensing ( Fig.…”

Section: Introductionmentioning

confidence: 99%

“…Second, another PC type in the NU encodes tilt velocity ( Fig. 1D , tilt-selective cells; (Hernández et al, 2020; Laurens et al, 2013b; Laurens & Angelaki, 2020; Stay et al, 2019). These cells modulate more during tilt than translation in phase to tilt velocity (Laurens & Angelaki, 2020).…”

Section: Introductionmentioning

confidence: 99%

“…1D , tilt-selective cells; (Hernández et al, 2020; Laurens et al, 2013b; Laurens & Angelaki, 2020; Stay et al, 2019). These cells modulate more during tilt than translation in phase to tilt velocity (Laurens & Angelaki, 2020). Importantly, 3D motion stimuli have revealed that these cells encode transformed rotation signals (dG/dt), and not egocentric rotation velocity (Ω) (Laurens et al, 2013b).…”

Section: Introductionmentioning

confidence: 99%

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Two functionally distinct Purkinje cell populations implement an internal model within a single olivo-cerebellar loop

Laurens

2021

Preprint

Self Cite

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Olivo-cerebellar loops, where anatomical patches of the cerebellar cortex and inferior olive project one onto the other, form an anatomical unit of cerebellar computation. Here, we investigated how successive computational steps map onto olivo-cerebellar loops. Lobules IX-X of the cerebellar vermis, i.e. the nodulus and uvula, implement an internal model of the inner ear's graviceptor, the otolith organs. We have previously identified two populations of Purkinje cells that participate in this computation: Tilt-selective cells transform egocentric rotation signals into allocentric tilt velocity signals, to track head motion relative to gravity, and translation-selective cells encode otolith prediction error. Here we show that, despite very distinct simple spike response properties, both types of Purkinje cells emit complex spikes that are proportional to sensory prediction error. This indicates that both cell populations comprise a single olivo-cerebellar loop, in which only translation-selective cells project to the inferior olive. We propose a neural network model where sensory prediction errors computed by translation-selective cells are used as a teaching signal for both populations, and demonstrate that this network can learn to implement an internal model of the otoliths.

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Periodic vertigo and downbeat nystagmus while supine: Dysfunction of Purkinje cells coding gravity

Lee,

Kim,

Yun

et al. 2023

Ann Clin Transl Neurol

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Cerebellar nodulus and uvula and their connections with the vestibular nuclei form the so‐called velocity‐storage circuit. Lesions involving the velocity‐storage circuit give rise to positional vertigo and nystagmus. Herein, we present a 32‐year‐old man with cerebellar nodulus and uvular hemorrhage who showed periodic vertigo and downbeat nystagmus in the supine position. To explain this unusual pattern, we adopted velocity‐storage model with a lesion on the neural connection between the gravity and inertia estimators, resulting in periodic neural impulses and a gravity bias in a specific position. This report expands the spectrum of central positional nystagmus due to dysfunction of the velocity‐storage mechanism.

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Simple spike dynamics of Purkinje cells in the macaque vestibulo-cerebellum during passive whole-body self-motion

Cited by 15 publications

References 85 publications

Anti-Yo antibody-positive paraneoplastic cerebellar degeneration in a patient with possible cholangiocarcinoma: A case report and review of the literature

Anti-Yo antibody-positive paraneoplastic cerebellar degeneration in a patient with possible cholangiocarcinoma: A case report and review of the literature

Two functionally distinct Purkinje cell populations implement an internal model within a single olivo-cerebellar loop

Periodic vertigo and downbeat nystagmus while supine: Dysfunction of Purkinje cells coding gravity

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