Purpose: To evaluate the efficiency, safety, and postoperative outcomes of intracameral air bubble tamponade (IABT) following phacoemulsification cataract surgery.Methods: We retrospectively reviewed all patients receiving phacoemulsification from 2016 to 2017 performed by one ophthalmic surgeon HCC. Incisions were closed with either non-IABT or IABT. In IABT group, air bubble was injected into the anterior chamber until its size reached 80% of the corneal diameter. Operation time, visual acuity (VA), and intraocular pressure (IOP) were evaluated pre- and post- operatively. Patients with intraoperative complications or with ocular diseases that may affect VA or IOP were excluded. Results: A total of 434 eyes of 331 patients were enrolled, with 201 cases in the IABT group and 233 cases in the non-IABT group. The operation time was significantly shorter in the IABT group (1365 vs. 1514 seconds, P= .005). There was no significant difference in logMAR VA (P=0.639) and IOP (P=0.860) between two groups in preoperative, postoperative 3 days, 10 days, 1 month, and 3 months. In 168 cases that had complete data of pre- and post-operative specular microscope examination, secondary analysis showed no significant difference in pre- and post-operative endothelial cell density, coefficient of variance, and hexagonal cells between both groups. Conclusion: IABT is a safe and effective method for sealing clear corneal incision in phacoemulsification cataract surgery.