Simplet/Fam53b is required for Wnt signal transduction by regulating β-catenin nuclear localization

Kızıl, Çağhan; Küchler, Beate; Yan, Jia-Jiun; Özhan, Günes; Moro, Enrico; Argenton, Francesco; Brand, Michael; Weidinger, Gilbert; Antos, Christopher L.

doi:10.1242/jcs.162701

Cited by 6 publications

(6 citation statements)

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“…Visual network-SC SNPs were also mapped to the METTL10-FAM53B readthrough ( RP11-12J10.3) and FAM53B gene, because of known chromatin interaction in fetal and adult cerebral cortex tissue (Figure 2a). FAM53B is required for Wnt signaling, a pathway important for cell regeneration 32 . Lastly, positional mapping of candidate SNPs within a 10kb window of a gene resulted in the identification of VIT, STRN, and HEATR5B genes for visual network-SC (Supplementary Table 5).…”

Section: Resultsmentioning

confidence: 99%

Specificity and overlap in the genetic architectures of functional and structural connectivity within cerebral resting-state networks

Tissink

Werme

Lange

et al. 2022

Preprint

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The functional connectivity and dynamics of resting-state networks (RSN-FC) are vital for cognitive functioning. RSN-FC is heritable and partially translates to the anatomical architecture of white matter, but the genetic component of structural connections of RSNs (RSN-SC) and their potential genetic overlap with RSN-FC remains unknown. Here we perform genome-wide association studies (Ndiscovery=24,336; Nreplication=3,412) and in silico annotation on RSN-SC and RSN-FC. We identify the first genes for visual network-SC, that are involved in axon guidance and synaptic functioning and show that genetic variation in RSN-FC impacts biological processes related to brain disorders that have previously been associated with FC alterations in those same RSNs. Correlations of the genetic components of RSNs are mostly observed within the functional domain, whereas less overlap is observed within the structural domain and between the functional and structural domains. This study advances the understanding of the complex functional organization of the brain and its structural underpinnings from a genetics viewpoint.

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Section: Resultsmentioning

confidence: 99%

Specificity and overlap in the genetic architectures of functional and structural connectivity within cerebral resting-state networks

Tissink

Werme

Lange

et al. 2022

Preprint

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“…3 Concerning the meta-analysis performed in this study, a DM gene, the FAM53B, was identified; which encodes a protein that is necessary to regulate the β-catenin-dependent Wnt signal transduction. 39 A GWAS has detected a variant in this gene as a risk for cocaine dependence in African-and European-American subjects. 40 Additionally, other polymorphisms in FAM53B are also associated with MDD and Alzheimer´s diseases.…”

Section: Discussionmentioning

confidence: 99%

Bioinformatic Analysis of Epigenomic Studies for Major Depressive Disorder

2022

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Background: Major depressive disorder (MDD) is a common psychiatric entity, being characterized by alterations in mood and in other clinical dimensions. Several epigenome-wide association studies (EWAS) for MDD have been published. Here, we aimed to identify common genes in EWAS and their convergence with multiple lines of genomic evidence. Methods: We carried out a computational analysis using data of EWAS, which included a meta-analysis for brain samples of MDD, a convergence analysis for brain and blood samples, and top results from available genome-wide expression and association data. Functional enrichment and protein-protein interaction network analyses were also done. Results: The meta-analysis for brain samples detected a significant gene, FAM53B. A list of forty-four top differentially methylated (DM) candidate genes was found, including GRM8, NOTCH4 and SEMA6A, in addition to known druggable genes. The binding-sites for brain-expressed transcription factors, CREB and FOXO1, were enriched in the top DM genes. The protein-protein interaction networks showed that DM genes for MDD, such as RPRM and TMEM14B, play a central role. Conclusion: In this study, we found integrative evidence for the possible role of novel candidate genes and pathways. These genes are involved in mechanisms of synaptic plasticity, which have been associated with several psychiatric disorders. Analysis of epigenetic factors have a great potential for the identification of the mechanisms involved in the pathogenesis of MDD, taking into account their possible role in the interaction between genetic factors and the environment.

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“…Forward genetic screens have identified mutations that affect the ErbB2 and ErbB3 receptor tyrosine kinases which disrupt tail regeneration (Rojas-Munoz et al, 2009). In addition to this study, other papers have identified chromatin remodelling components, the Wnt/b-catenin signalling modifier Fam53b and nitric oxide synthases as being expressed during larval tail regeneration (Kizil et al, 2014, Kizil et al, 2009, Lepiller et al, 2009, Pfefferli et al, 2014. It is likely that these pathways are also active during fin fold regeneration but a direct comparison has not been made.…”

Section: Tail Regenerationmentioning

confidence: 97%

Linking wound response and inflammation to regeneration in the zebrafish larval fin

Roehl

2018

Int. J. Dev. Biol.

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The study of regenerative biology aims to elucidate the innate ability of organisms to replace tissues or organs after they have been removed or damaged. The zebrafish is a powerful model for the analysis of intracellular signalling and cell behaviour and as such has made major contributions to our understanding of regenerative biology. The larval fin fold is an emerging model to understand how different signalling pathways interact to coordinate regeneration. Tissue damage causes the immediate release of signals that initiate wound closure and inflammation. Following this, regenerative cells proliferate and migrate to the damaged area. Each of these processes has been analysed using the larval fin fold model to provide a framework for how fin regeneration takes place. This review gives an overview of the current state of this field with particular emphasis on the different signalling networks that are required during fin fold regeneration.

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Simplet/Fam53b is required for Wnt signal transduction by regulating β-catenin nuclear localization

Cited by 6 publications

References 1 publication

Specificity and overlap in the genetic architectures of functional and structural connectivity within cerebral resting-state networks

Specificity and overlap in the genetic architectures of functional and structural connectivity within cerebral resting-state networks

Bioinformatic Analysis of Epigenomic Studies for Major Depressive Disorder

Linking wound response and inflammation to regeneration in the zebrafish larval fin

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