Simplificação terapêutica com lamivudina e dolutegravir em pacientes vivendo com HIV no Ceará (Estudo LAMDO)

Vasconcelos, Melina Maria Loiola Melo; Arruda, Érico Antônio Gomes de; Ibiapina, Amanda Pinheiro; Costa, Lara Farias Lustosa da; Araújo, Ana Luiza Maria Viana de; Medeiros, Melissa Soares

doi:10.33448/rsd-v11i9.32251

Cited by 2 publications

(1 citation statement)

References 17 publications

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“…Furthermore, studies have shown that a shorter period of viral suppression before switching can increase the risk of virological failure, and since there is no possibility of prior genotyping, dual therapy is recommended as a simplification after efficient virological suppression. (VASCONCELOS et al, 2022). There is no consensus on the initial viral load when choosing dual therapy as a therapeutic option.…”

Section: Efficacymentioning

confidence: 99%

Analysis of the Epidemiological Profile and Effectiveness of the Use of Dual Therapy in Hiv Patients at the Infectology Outpatient of Hospital Santa Casa De Misericórdia De Vitória/Es

Santos,

Lievori,

Fiuza

et al. 2024

JHS

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Objective: The objective of the work is to evaluate the effectiveness of using dual therapy in HIV treatment and the epidemiological profile of patients at the Infectious Diseases Outpatient Clinic of Hospital ``Santa Casa de Misericórdia de Vitória``. Method: This is an observational, analytical and descriptive study. The initial sample was selected from a list of patients undergoing HIV treatment at the infectious disease outpatient clinic and selection of patients on dual therapy. Information on the epidemiological profile was collected and efficacy was defined by the suppression of the viral load within a period of 6 months to 1 year after the start of dual therapy. Results: A total of 120 patients met the study inclusion criteria and 95 remained after the exclusion criteria. 63 patients were using dual therapy with DTG + DRV/r, 26 were using DTG + 3TC and 6 patients were using DRV + 3TC. The main reason for changing therapy was due to toxicity from the triple regimen. The average age of the sample was 60.6 years. Efficacy of dual therapy was achieved in 87 patients (91.6%). Conclusion: It is possible to verify the high effectiveness of dual therapy in suppressing viral load, which makes it an appropriate alternative for cases with contraindications or intolerant to the triple regimen.

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Section: Efficacymentioning

confidence: 99%

Analysis of the Epidemiological Profile and Effectiveness of the Use of Dual Therapy in Hiv Patients at the Infectology Outpatient of Hospital Santa Casa De Misericórdia De Vitória/Es

Santos,

Lievori,

Fiuza

et al. 2024

JHS

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Efficacy of Lamivudine and Dolutegravir simplification therapy compared with triple therapy in Northeast Brazil (LAMDO Study)

Naiara Lima,

Natália Nogueira,

Sofia Rodrigues

et al. 2024

J HIV Clin Sci Res

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Background: Modern antiretroviral therapy provides numerous effective and well-tolerated treatment options for individuals living with HIV. However, due to medication tolerability, toxicity, and cost optimization associated with the emergence of highly potent drugs, dual therapy has emerged as a new therapeutic alternative for patients with viral suppression. Observational studies worldwide are being conducted to assess the effectiveness of dual therapy in people living with HIV/AIDS. A real-world study is important to validate the findings obtained in controlled studies. Objective: Assess the effectiveness of dual therapy with lamivudine and dolutegravir compared to triple therapy in real-life settings. Methods: The study was conducted at São José Infectious Diseases Hospital, a tertiary referral hospital in the state of Ceará, northeast Brazil, for the treatment of PLWHA. Results: A total of 521 patients were taking double therapy with lamivudine plus dolutegravir and 450 patients were in triple therapy, mostly in the use of association with dolutegravir, were analyzed. Patients on dual therapy had a higher median age compared to those on triple therapy. A statistically significant higher viral suppression was observed in patients on dual therapy compared to triple therapy (p < 0,001). Viral suppression on dual therapy under 200 copies was 97.2%. There was a statistically significant higher percentage of patients with higher CD4/CD8 ratio using triple therapy compared to dual therapy. Conclusion: The current study suggests a higher effective response to dual therapy compared to triple therapy in PLWHA in the real-world, supporting therapy simplification as a sustainable option to maintain virological suppression in patients experiencing toxicity or comorbidities.

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Simplificação terapêutica com lamivudina e dolutegravir em pacientes vivendo com HIV no Ceará (Estudo LAMDO)

Cited by 2 publications

References 17 publications

Analysis of the Epidemiological Profile and Effectiveness of the Use of Dual Therapy in Hiv Patients at the Infectology Outpatient of Hospital Santa Casa De Misericórdia De Vitória/Es

Analysis of the Epidemiological Profile and Effectiveness of the Use of Dual Therapy in Hiv Patients at the Infectology Outpatient of Hospital Santa Casa De Misericórdia De Vitória/Es

Efficacy of Lamivudine and Dolutegravir simplification therapy compared with triple therapy in Northeast Brazil (LAMDO Study)

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