Simplified antibiotic treatment for paediatric osteoarticular infections achieved good outcomes

Ossurarson, Freythor; Thors, Valtýr; Haraldsson, Ásgeir

doi:10.1111/apa.16510

Cited by 3 publications

(1 citation statement)

References 28 publications

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“…Alcobendas et al and Ossurarson et al have investigated the efficacy of simplified antibiotic treatment in children with primary haematogenous osteoarticular infection [ 63 , 64 ]. Alcobendas Rueda et al compared 893 children with primary haematogenous osteoarticular infection treated by intravenous antibiotics with 64 children who received oral-only antibiotic therapy.…”

Section: Introductionmentioning

confidence: 99%

News in paediatric orthopaedic surgery: an overview of the latest advances in paediatric orthopaedics and traumatology (2020–2023)

Mainard

Canavese

2023

International Orthopaedics (SICOT)

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Purpose We propose to survey — even if arbitrarily — the publications in paediatric orthopaedics and traumatology that have had the greatest impact on the specialty during the period extending from the beginning of the COVID-19 pandemic in December 2020 and the end of all health restrictions in March 2023. Methods Only studies with a high level of evidence or clinical relevance were selected. We briefly discussed the results and conclusions of these quality articles to situate them in relation to the existing literature and current practice. Results Publications are presented by dividing traumatology and orthopaedics whose publications are further subdivided according to anatomical districts; articles concerning neuro-orthopaedics, tumours, and infections were presented separately while sports medicine is jointly presented with knee-related articles. Conclusions Despite the difficulties encountered during the global COVID-19 pandemic (2020–2023), orthopaedic and trauma specialists, including paediatric orthopaedic surgeons, have maintained a high level of scientific output, in terms of quantity and quality of production.

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Section: Introductionmentioning

confidence: 99%

News in paediatric orthopaedic surgery: an overview of the latest advances in paediatric orthopaedics and traumatology (2020–2023)

Mainard

Canavese

2023

International Orthopaedics (SICOT)

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Antibiotic Selection, Route of Administration, and Duration in Hematogenous Osteomyelitis in Children

王

2024

ACM

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Editorial: An update on pediatric skeletal system infections

Yagupsky

Ceroni²

2023

Front. Pediatr.

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Editorial on the Research Topic An Update on Pediatric Skeletal System InfectionsOsteoarticular infections (OAIs) in pediatric patients are medical emergencies that require early diagnosis and adequate treatment to avoid severe septic complications, prolonged morbidity, and long-term functional disability (1). Although traumatic inoculation of bacteria into the joint space and bones or dissemination from a contiguous soft tissue focus may occur, in most cases, pathogens reach the skeletal tissues through the hematogenous route (2). Because the incidence of bacteremia is elevated in immunologically naïve young children, the incidence of septic arthritis and osteomyelitis is higher in early childhood (1).Early diagnosis of skeletal infections, identification of their etiologic agent, and prompt administration of adequate antimicrobial therapy are cornerstones of managing the disease, avoiding clinical deterioration, and preventing permanent orthopedic sequelae (3). Traditionally, culture isolation of the etiologic agent, its identification, and determination of its antibiotic susceptibility was performed by conventional methods. However, causative organisms may be present in the specimen at low concentrations, difficult to isolate, and/or children may have been empirically administered antibiotics before cultures were obtained. Consequently, many pediatric joint and bone infections remained bacteriologically unconfirmed (4). Because the microbiology laboratory results are obtained with a 2-3-day delay and the danger of administering an inappropriate or poorly efficient antibiotic, the initial therapy of bone and joint infections usually consists of wide-spectrum antimicrobial drugs, including those that provide appropriate coverage of Staphylococcus aureus (3). To ensure therapeutic success, antibiotics are administered through the intravenous route in the early phase and switched to oral therapy after body temperature has normalized for 24 h, local findings and motion have improved, and C-reactive protein (CRP) levels have decreased (1).Technological progress has revolutionized the epidemiology, diagnosis, and management of pediatric OAI in recent decades, as summarized in Table 1.The present Special Issue provides an update on managing these skeletal system infections in children and the areas of controversy and current research to improve the diagnosis, shorten the duration of intravenous therapy, and reduce hospitalization length.The article by Porsch et al. summarizes our current knowledge of the virulence factors of Kingella kingae. Advances in the culture methods and especially the increasing use of molecular detection methods have resulted in recognition of the bacterium as the prime etiology of hematogenous septic arthritis, osteomyelitis, spondylodiscitis, and tenosynovitis in children aged 6-48 months (8). Intensive research conducted over the last two decades has

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Simplified antibiotic treatment for paediatric osteoarticular infections achieved good outcomes

Cited by 3 publications

References 28 publications

News in paediatric orthopaedic surgery: an overview of the latest advances in paediatric orthopaedics and traumatology (2020–2023)

News in paediatric orthopaedic surgery: an overview of the latest advances in paediatric orthopaedics and traumatology (2020–2023)

Antibiotic Selection, Route of Administration, and Duration in Hematogenous Osteomyelitis in Children

Editorial: An update on pediatric skeletal system infections

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