Simplified Dynamic Energy Budget model for analysing ecotoxicity data

Jager, Tjalling; Zimmer, Elke I.

doi:10.1016/j.ecolmodel.2011.11.012

Cited by 122 publications

(134 citation statements)

References 22 publications

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“…Dynamic Energy Budget (DEB) models are particularly useful for such quantitative assessments. DEB theory is one of the most comprehensive framework for bioenergetics (Kooijman, 2001;Nisbet et al, 2000), and models based on this theory have been extensively applied to understand the effects of chemical stress (see Jager and Zimmer, 2012;Jager et al, 2006) and environmental factors such as food and temperature (e.g., Freitas et al, 2009), including the ecological consequences of climate change (e.g., Teal et al, 2012). Recently, Muller and Nisbet (2014) presented a DEB model for the effects of ocean acidification on calcifying phytoplankton (coccolithophores).…”

Section: Introductionmentioning

confidence: 99%

Near-future ocean acidification impacts maintenance costs in sea-urchin larvae: Identification of stress factors and tipping points using a DEB modelling approach

Jager¹,

Ravagnan

Dupont

2016

Journal of Experimental Marine Biology and Ecology

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Section: Introductionmentioning

confidence: 99%

Near-future ocean acidification impacts maintenance costs in sea-urchin larvae: Identification of stress factors and tipping points using a DEB modelling approach

Jager¹,

Ravagnan

Dupont

2016

Journal of Experimental Marine Biology and Ecology

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“…In short, uptake is taken proportional to external concentration c d (nM). Eliminationk e (d −1 ) is taken proportional to internal concentration [M Q ] (nmol cm −3 ) and inversely proportional to length (Kooijman, 2010;Jager and Zimmer, 2012).…”

Section: One Compartment Toxico-kinetic Modulementioning

confidence: 99%

“…Therefore there is a need to specify energetics (growth and reproduction) in combination with toxico-kinetics (dynamics of internal concentration) in a unique theoretical framework (Jager et al, 2006;Jager and Klok, 2010;Jager and Zimmer, 2012). A well worked out quantitative theory on metabolic organisation, Dynamic Energy Budget (deb) theory, provides the toolkit necessary to address this problem (Kooijman, 2010).…”

Section: Introductionmentioning

confidence: 99%

Effects of uranium on the metabolism of zebrafish, Danio rerio

et al. 2012

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The increasing demand for nuclear energy results in heightened levels of uranium (U) in aquatic systems which present a potential health hazard to resident organisms. The aim of this study was to mechanistically assess how chronic exposure to environmentally relevant concentrations of U perturbs the complex interplay between feeding, growth, maintenance, maturation and reproduction throughout the life-cycle of an individual. To this end we analysed literature-based and original zebrafish toxicity data within a same mass and energy balancing conceptual framework. U was found to increase somatic maintenance leading to inhibition of spawning as well as increase hazard rate and costs for growth during the early life stages. The fish's initial conditions and elimination through reproduction greatly affected toxico-kinetics and effects. We demonstrate that growth and reproduction should be measured on specific individuals since mean values were hardly interpretable. The mean food level differed between experiments, conditions and individuals. This last 'detail' contributed substantially to the observed variability by its combined effect on metabolism, toxic effects and toxico-kinetics. The significance of this work is that we address exactly how these issues are related and derive conclusions which are independent of experimental protocol and coherent with a very large body of literature on zebrafish eco-physiology.

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“…The underlying explanation may be that organisms devote energy to ameliorate the effects of stressors and as a result have less energy available for growth and reproduction. These concepts have been formalized with the application of Dynamic Energy Budget Theory to problems in ecotoxicology (e.g., Nisbet et al, 2000;Jager and Zimmer 2012;Martin et al, 2013). Importantly, the theory would suggest that when the original stress is reduced or eliminated, animals would return to their original functional state.…”

Section: Discussionmentioning

confidence: 99%