Simplified intravenous nutrition using Intralipid-based mixtures in patients with serious gastrointestinal disease

Burnham, W R; Knott, Chloe; Cook, John A.; Langman, M. J. S.

doi:10.1136/pgmj.59.692.360

Cited by 10 publications

(7 citation statements)

References 16 publications

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“…Total parenteral nutrition (TPN) by means of premixed fat, glucose, amino acids, fat-and water-soluble vitamins, trace elements and electolytes in 3-litre plastic bags is now common, The physical and chemical stability of such systems has been extensively evaluated (1,2) and their clinical usefulness has been documented (3). *To whom correspondence should be sent.…”

Section: Introductionmentioning

confidence: 99%

Vitamin Stability in a TPN Mixture Stored in an Eva Plastic Bag

1986

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In order to examine the stability of vitamins in a T P N admixture stored in 3-litre plastic (EVA) bags, two different stability studies were performed. In the first experiment the TPN admixture was stored in darkness at 2-8°C for 96 h and the stability of vitamins determined. The vitamins examined were retinyl palmitate, a-tocopherol, thiamine mononitrate, sodium ascorbate (analysed as reduced ascorbic acid and dehydroascorbic acid), sodium riboflavin-5'-phosphate, pyridoxine hydrochloride, nicotinamide, folic acid, biotin, sodium pantothenate and cyanocobalamin.In the second test the stability of vitamins was determined during simulated infusion from the bag containing the admixture. The vitamins examined were retinyl palmitate, a-tocopherol, sodium riboflavin-5'phosphate and sodium ascorbace (analysed as reduced ascorbic acid and dehydroascorbic acid).The vitamin stability was found to be acceptable for all vitamins except ascorbic acid and folic acid. Total ascorbic acid is the sum of reduced ascorbic acid and dehydroascorbic acid (DHA). It is important to estimate the total ascorbic acid concentration because DHA is also biological active.About 50% of the nominal total ascorbic acid remained after 96 h of storage at 2 4°C in darkness, or after 24 h of simulated infusion initiated immediately after mixing.With folic acid there appears to be assay interference which requires further investigation. I N T R O D U C T I O NTotal parenteral nutrition (TPN) by means of premixed fat, glucose, amino acids, fat-and water-soluble vitamins, trace elements and electolytes in 3-litre plastic bags is now common, The physical and chemical stability of such systems has been extensively evaluated (1,2) and their clinical usefulness has been documented (3).

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Section: Introductionmentioning

confidence: 99%

Vitamin Stability in a TPN Mixture Stored in an Eva Plastic Bag

1986

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“…Historically, IVLE were administered separately from the PN solution until the AIO concept was introduced into clinical practice in the 1970s by French 33 and subsequently adopted by several British centers 34 . Advantages of the AIO system are as follows: a constant, continuous, and simultaneous infusion of all nutrients and optimized nutrient utilization; only 1 pump and intravenous (IV) line needed; decreased risk of microbial contamination by less manipulation; inhibitive properties on microbial growth; decreased risk of error; decreased nursing time; decreased risk of physical instability from mixing at the Y‐site; simple and practical use in home PN (HPN).…”

Section: Oil Content (%) In Commercially Manufactured Intravenous Lipmentioning

confidence: 99%

Formulation, Stability, and Administration of Parenteral Nutrition With New Lipid Emulsions

Hardy

Puzovic

2009

Nut in Clin Prac

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Intravenous lipid emulsions (IVLE) are an important source of energy and essential fatty acids and their incorporation into pediatric and adult parenteral nutrition (PN) regimens has revolutionized nutrition therapy. However, their clinical use has not been without risk, and will continue to remain so because of the intravenous route of administration. Pharmaceutical and microbiological concerns are centered around the methods of compounding all-in-one (AIO) admixtures, but these can be largely minimized with today's technologies and advanced understanding of aseptic principles. Modern lipid products, based on olive, coconut, and/or fish oils, have demonstrable formulation and clinical benefits over traditional soybean and safflower IVLE and, when combined in the new multi-chamber bags, can also offer improvements in stability and safety. This review outlines the rationale for different lipid formulations in PN admixtures, reviews the factors influencing stability and efficacy of lipid-based AIO regimens and evaluates some technologies for minimizing peroxidation and maximizing stability of AIO admixtures.

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“…Intravenous nutrition can be simplified if Intralipid is mixed with other nutrients in a single 3litre bag before infusion (Burnham et al, 1981). The purpose of the present study was to compare blood platelet behaviour before, during and after infusion of the mixture that is currently being used.…”

Section: Introductionmentioning

confidence: 99%

Blood platelet behaviour during infusion of an Intralipid based intravenous feeding mixture

Burnham

Cockbill

Heptinstall

et al. 1982

Postgraduate Medical Journal

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SummaryBlood platelet behaviour was studied in six patients during infusion of an Intralipid-based intravenous feeding mixture. Lower concentrations of sodium arachidonate were required to induce platelets to aggregate and to undergo a release reaction during intravenous feeding than were required before or after intravenous feeding. This change was not due to a change in serum albumin level. The platelet behaviour that was induced by adenosine diphosphate or by adrenaline remained unchanged during intravenous feeding.

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Simplified intravenous nutrition using Intralipid-based mixtures in patients with serious gastrointestinal disease

Cited by 10 publications

References 16 publications

Vitamin Stability in a TPN Mixture Stored in an Eva Plastic Bag

Vitamin Stability in a TPN Mixture Stored in an Eva Plastic Bag

Formulation, Stability, and Administration of Parenteral Nutrition With New Lipid Emulsions

Blood platelet behaviour during infusion of an Intralipid based intravenous feeding mixture

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