Simplified Method to Study Stability of Pharmaceutical Preparations

Simplified Method to Study Stability of Pharmaceutical Systems: A Response

“…However, the assumptions involved here are self-defeating. It assumes that all preparations have similar initial concentrations and that there is no overage in the product (1). It should be reiterated that a f 5 % variation in the content is routinely acceptable.…”

Simplified Method to Study Stability of Pharmaceutical Systems

“…0%. 1) where f ( C ) is some function of concentration, (hen integrating between the limits t:! and t l (t2t l = t,):…”

“…The reaction rate at a specific fraction of decomposition was estimated by linear interpolation. In the method suggested previously, t , can be estimated similarly by linear interpolation, by alternative methods (e.g., cubic splines, polynomial regression), or by assuming knowledge of the functional relationship v( C)] as was done previoulsy ( 1 ) .…”

“…However, the assumptions involved here are self-defeating. It assumes that all preparations have similar initial concentrations and that there is no overage in the product (1). It should be reiterated that a f 5 % variation in the content is routinely acceptable.…”