Simplifying the assessment of human breast cancer by mapping a micro‐scale heterogeneity index in optical coherence elastography

Chin, Lixin; Latham, Bruce; Saunders, Christobel; Sampson, David D.; Kennedy, Brendan F.

doi:10.1002/jbio.201600092

Cited by 30 publications

(17 citation statements)

References 45 publications

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“…Here, and in previous studies, we have presented micro-elastograms as overlays on OCT images, but further work on visualization must be performed to simplify images. Previously, we have identified regions of tumor by mapping a heterogeneity index of qualitative micro-elastograms [43]. In ongoing work, we will further investigate image fusion to aid with clinical interpretation.…”

Section: Discussionmentioning

confidence: 99%

Wide-field quantitative micro-elastography of human breast tissue

Allen

Kennedy

Fang

et al. 2018

Biomed. Opt. Express

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Currently, 20-30% of patients undergoing breast-conserving surgery require a second surgery due to insufficient surgical margins in the initial procedure. We have developed a wide-field quantitative micro-elastography system for the assessment of tumor margins. In this technique, we map tissue elasticity over a field-of-view of ~46 × 46 mm. We performed wide-field quantitative micro-elastography on thirteen specimens of freshly excised tissue acquired from patients undergoing mastectomy. We present wide-field optical coherence tomography (OCT) images, qualitative (strain) micro-elastograms and quantitative (elasticity) micro-elastograms, acquired in 10 minutes. We demonstrate that wide-field quantitative micro-elastography can extend the range of tumors visible using OCT-based elastography by providing contrast not present in either OCT or qualitative microelastography and, in addition, can reduce imaging artifacts caused by a lack of contact between tissue and the imaging window. Also, we describe how the combined evaluation of OCT, qualitative micro-elastograms and quantitative micro-elastograms can improve the visualization of tumor.

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Section: Discussionmentioning

confidence: 99%

Wide-field quantitative micro-elastography of human breast tissue

Allen

Kennedy

Fang

et al. 2018

Biomed. Opt. Express

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“…applications-for oncology- [29][30][31] and for ophthalmology [32][33][34] of phase-sensitive strain and stiffness mapping were reported in the past. Obtaining of nonlinear curves was demonstrated and discussed in detail in Refs.…”

Section: Optical Coherence Elastography Imagingmentioning

confidence: 99%

Photoacoustic elastography imaging: a review

Singh

Thomas

2019

J. Biomed. Opt.

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Elastography imaging is a promising tool-in both research and clinical settings-for diagnosis, staging, and therapeutic treatments of various life-threatening diseases (including brain tumors, breast cancers, prostate cancers, and Alzheimer's disease). Large variation in the physical (elastic) properties of tissue, from normal to diseased stages, enables highly sensitive characterization of pathophysiological states of the diseases. On the other hand, over the last decade or so, photoacoustic (PA) imaging-an imaging modality that combines the advantageous features of two separate imaging modalities, i.e., high spatial resolution and high contrast obtainable, respectively, from ultrasound-and optical-based modalities-has been emerging and widely studied. Recently, recovery of elastic properties of soft biological tissues-in addition to prior reported recovery of vital tissue physiological information (Hb, HbO 2 , SO, and total Hb), noninvasively and nondestructively, with unprecedented spatial resolution (μm) at penetration depth (cm)-has been reported. Studies demonstrating that combined recovery of mechanical tissue properties and physiological information-by a single (PA) imaging unit-pave a promising platform in clinical diagnosis and therapeutic treatments. We offer a comprehensive review of PA imaging technology, focusing on recent advances in relation to elastography. Our review draws out technological challenges pertaining to PA elastography (PAE) imaging, and viable approaches. Currently, PAE imaging is in the nurture stage of its development, where the technology is limited to qualitative study. The prevailing challenges (specifically, quantitative measurements) may be addressed in a similar way by which ultrasound elastography and optical coherence elastography were accredited for quantitative measurements. © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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“…The obtained data are presented in a graphic form (elastogram). They also require comparison with the images obtained with the standard tissue staining techniques (haematoxylin and eosin/H&E/stain) [33,34].…”

Section: Radiological (Imaging) Techniquesmentioning

confidence: 99%

Current possibilities of peri-operative evaluation of the radicality of primary tumour resection in breast cancer patients treated with BCT (breast conserving treatment)

Nowikiewicz¹,

Zegarski²

2018

Nowotwory. Journal of Oncology

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In accordance with the current standards of treatment of breast cancer patients, the application of breast conserving treatment (BCT) requires a radical resection of the tumour and post-operative radiotherapy. This means the necessity of obtaining tumour-free primary resection margins, i.e. without the presence of cancer tissue. In spite of the correct pre-operative diagnostic process and appropriate surgical treatment, in about 20-30% BCT cases, the tumour resection turns out to be not radical. The necessity of performing another surgery leads to the prolongation of the overall operative time and increases costs. A histopathological evaluation of the margin of the primary tumour resection performed on an immediate basis is not a standard procedure in patients undergoing BCT. In spite of the definite limitations of this method, its application may decrease the overall rate of revision surgeries. The paper discusses some other currently available possibilities of perioperative evaluation of the radicality of primary tumour resection in breast cancer patients treated with BCT.

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Simplifying the assessment of human breast cancer by mapping a micro‐scale heterogeneity index in optical coherence elastography

Cited by 30 publications

References 45 publications

Wide-field quantitative micro-elastography of human breast tissue

Wide-field quantitative micro-elastography of human breast tissue

Photoacoustic elastography imaging: a review

Current possibilities of peri-operative evaluation of the radicality of primary tumour resection in breast cancer patients treated with BCT (breast conserving treatment)

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