Learning communication skills is central in medical education. Clinical simulation provides conditions to foster comprehensive teaching and learning processes, although it is necessary to understand student acceptance as a way to evaluate and improve the strategy. The objective of this study was to analyze the perception of medical students after introducing clinical simulation sessions to optimize the teaching and learning processes of communication skills. The study design is observational, cross-sectional, mixed, and uses census sampling. A survey was conducted through a questionnaire, and a descriptive analysis of the results was performed. The results reveal a generally good perception, where the majority of students highlighted the debriefing space or final reflection (64.8%), while 27.8% valued clinical simulation as a space for applying knowledge and more than 20% referred to the simulation scenario or the experience with a simulated patient. In conclusion, the most notable space was debriefing as an area for reflection and learning, although other appreciated aspects such as the application of knowledge or the use of a simulated patient are also important in understanding clinical simulation as a tool for learning communication skills.